Peter Little on Surprises in the HGP
  Peter Little     Biography    
Recorded: 30 May 2003

It surprised me that it actually got done in the way it was done. I had predicted that the way the way it would be done is by lots of different groups working together. And it became obvious as time went past that it was simply impossible. And that socially a really difficult decision to make; how do you make scientists stop doing things. And so that was the real surprise was that decision was made. And it was a complicated decision, which is not just scientific. So seeing that decision being made and then watching how the big consortiums then just pushed through with it was really very, it was very powerful. Very exciting.

Peter Little is a bioinformatics researcher, professor of medical biochemistry and the head of the School of Biotechnology and Biomolecular Sciences at the University of New South Wales in Sydney, Australia. He received his Ph.D. working with recombinant DNA under Ed Southern and Peter Walker at Edinburgh University. In 1976, Little cloned a human gene – the second time this was ever accomplished.

Little’s laboratory studies the genetic basis of gene expression, and genetic variation as it pertains to the regulatory regions of the genes. He has hypothesized that there are two types of genetic variation that alter gene expression. His lab has also created advanced techniques for testing genetically influenced transcript variations.

He comes to Cold Spring Harbor Laboratory regularly for genome meetings and symposia.