Recorded: 30 May 2003
I read a book. I read a book when I was about ten or twelve years old. It was a book on DNA, The Structure of Life, by a gentleman called Royston Close. It was a Penguin book. I didn’t understand very much of it. And I read it repeatedly, and it just stuck. From the age of 12 I wanted to be a scientist and I wanted to work on DNA. And so when I finally went to University and decided to do a PhD. I was actually going to do a PhD somewhere completely different. I wanted to work on DNA, so I went off to Edinburgh very late, applied for a PhD position and was accepted to go and work on DNA. That’s what I’ve done ever since. And it was great decision.
Peter Little is a bioinformatics researcher, professor of medical biochemistry and the head of the School of Biotechnology and Biomolecular Sciences at the University of New South Wales in Sydney, Australia. He received his Ph.D. working with recombinant DNA under Ed Southern and Peter Walker at Edinburgh University. In 1976, Little cloned a human gene – the second time this was ever accomplished.
Little’s laboratory studies the genetic basis of gene expression, and genetic variation as it pertains to the regulatory regions of the genes. He has hypothesized that there are two types of genetic variation that alter gene expression. His lab has also created advanced techniques for testing genetically influenced transcript variations.
He comes to Cold Spring Harbor Laboratory regularly for genome meetings and symposia.