Recorded: 31 May 2003
I assume it will become cheaper to sequence large chunks of the genome. Craig Venter said yesterday that he hoped to be able to sequence a person’s whole genome for just one thousand dollars. We can't do that right now but maybe he will be able to in the near future. And then maybe you can put on a chip, all the points where a person’s genome differs from some population standard. That will lay the basis for genomic medicine. So the genome will sort of enter into our lives in a much more detailed way, I think. That’s one easy prediction.
Philip Green is a professor of genome sciences, an adjunct professor of the Computer Science and Engineering Department at the University of Washington, a Howard Hughes Medical Institute Investigator, and was recently elected into the National Academy of Sciences.
Green designs software packages which aid in making genetic maps and identifying genes within the genome. He is concerned with constructing computational tools to understand cell functioning at a molecular level. Green has created the program Phred, which manages the data generated by the Human Genome Project and which is being used to help determine the most common variations in human DNA. Green’s laboratory is working to construct a gene-annotated genome sequence. His lab has modified the number of genes thought to be in the human genome—it is substantially fewer than had been previously believed.
Green spoke at the 68th Cold Spring Harbor Symposium focused on the Genome of Homo Sapiens.