Recorded: 22 Mar 2003
I love architecture. And I think if I had another choice at the time that’s what I’d chose.
In fact there’s similarities between science and architecture because in each case you’re creating something for posterity. In science you are creating ideas, knowledge; in architecture you are creating structures, buildings that, you know, that could be around forever.
Tom Maniatis, molecular biologist, is a leader in the field of recombinant DNA. At Vanderbilt University he completed his Ph.D. studying DNA wide-angle scattering. He became a postdoctoral fellow and professor at Harvard University and met Jim Watson just before he became director of Cold Spring Harbor Laboratory.
While Maniatis was beginning experimentation with cDNA cloning and gene regulation of higher cells, the controversy over recombinant DNA in Cambridge stunted his progression. Watson offered Maniatis a position at CSHL where he could work more efficiently to understand the methods of recombinant DNA. At CSHL, Maniatis completed full-length synthesis of double stranded DNA and actual cloning of cDNA.
He is currently a professor of molecular and cellular biology at Harvard University studying the mechanisms involved in the regulation of RNA transciption and pre-messenger RNA splicing. He studies transcription to understand how eukaryotic genes are activated by viral infection and extracellular signals.