Program
Organizers: Anu Suomalainen, John E. Walker, Douglas C. Wallace & Mila Pollock
- Bruce Stillman
- Welcome and Introduction
- Ludmila Pollock
- Welcome and Introduction
- Douglas Wallace
- Welcome and Introduction
Session 1: Mitochondrial Biology, Bioenergetics, Biogenesis and Disease
Chair: Anu Suomalainen University of Helsinki
- John Walker
- Some landmarks in research into mitochondria
- David G. Nicholls
- Mitochondrial bioenergetics and the chemiosmotic revolution
- Douglas Wallace
- Historical perspective of mitochondrial genetics and disease
- Ian Young
- Unlocking the secrets to the human mitochondrial genome- The historic Mitochondrial Sequencing Project in the Sanger Laboratory in Cambridge
Session 2: The origins of the organelle
- Nick Lane
- The Flux Capacitor- How mitochondria shape the evolution of complexity
- Michael W. Gray
- What do we really know about the origin of mitochondria?
- Dan Mishmar
- Co-regulation of the mitochondrial and nuclear gene expression- Adaptation to the eukaryote host regulatory system
Session 3: Complex I: From Structure to Disease
Chair: Peter Rich University College London
- Peter Rich
- Structure, coupling mechanism and possible control points of cytochrome c oxidase
- Leonid Sazanov
- Coupling mechanism of complex I
- Judy Hirst
- Cryo-EM structures of complex I from mouse heart mitochondria in biochemically-defined states
- Henry Higgs
- Stimulus-induced interactions between actin and mitochondria- Effects on ER calcium exchange and mitochondrial dynamics
Session 4: Mitochondrial DNA: Structure, Function and Inheritance
Chair: Anne Chomyn California Institute of Technology
- Anne Chomyn
- Mitochondrial gene identification
- Patrick Chinnery
- Treatments for mitochondrial disease- Past, present and future
- Laurie S. Kaguni
- POLG, the mitochondrial replicase- From structural enzymology to clinical applications
- James B. Stewart
- Keeping mitochondrial DNA in shape between generations
- Marcia Haigis
- Mitochondrial reprogramming in cancer
Session 6: Mitochondrial Expression System and Proteome
Chair: Maria Falkenberg University of Gothenburg
- Nils-Göran Larsson
- The mitochondrial nucleoid and mtDNA gene expression
- Claes Gustafsson
- Mitochondrial DNA separation in human cells
- Vasmi K. Mootha
- Genomics approaches to mitochondrial biology and disease
- Emine C. Koc
- Mitochondrial ribosomal proteins and their involvement in complex metabolic disorders
- Eric A. Shoubridge
- Interrogating the mitochondrial interactome using BiolD
Session 7: Mitochondrial Protein Import Systems and Metabolic Transporters
Chair: Ferdinando Palmieri University of Bari Aldo Moro
- Nikolaus Pfanner
- Mitochondrial machineries for import and assembly of proteins
- Edmund R. Kunji
- The molecular mechanism of transport by the mitochondrial ADP/ATP carrier
- Jared Rutter
- Pyruvate metabolism and cell fate decisions
Session 8: Mitochondrial Diseases, Past and Present
Chair: Marni Falk Children’s Hospital of Philadelphia
- Eric A. Schon
- The role of ER-mitochondrial contacts in the pathogenesis of Alzheimer disease
- Carla Koehler
- Small molecule modulators for mitochondrial biogenesis
- Massimo Zeviani
- Perturbed mitochondrial homeostasis in the pathogenesis of mitochondrial disorders
- Agnès Rötig
- Impaired transferrin receptor palmitoylation and recycling in neurodegeneration with brain iron accumulation
Session 9: Mitochondrial Regulation of Metabolism
Chair: Valerio Carelli University of Bologna School of Medicine
- Valerio Carelli
- Optic nerve atrophy- The tip of the mito-neurodegeneration iceberg
- Orian Shirihai
- Mitochondrial dynamics in the regulation of fuel preference and energy expenditure
- Aleksandra Trifunovic
- Keeping complex I in shape
- Charles Brenner
- The NAD metabolome in life and resistance to metabolic stress- It’s not magic, but homeostasis
- György Hajnóczky
- Ca2+-dependent control of the mitochondrial CA2+ uniporter by MICU1 and neuromuscular disease
- Bruce M. Spiegelman
- Regulation of mitochondrial bioenergetics and energy expenditure- Futile creatine cycle
- Anu Suomalainen
- The integrated mitochondrial stress response in mammalian mitochondrial disease
- Navdeep S Chandel
- Mitochondria as signaling organelles
Session 10: Mitochondria, Calcium Signaling and Cell Death
Chair: John Walker University of Cambridge
- Rosario Rizzuto
- Molecular control of mitochondrial calcium uptake
- Paolo Bernardi
- Between energy conservation and energy dissipation- The dual life of F-ATP synthase
- Luca Scorrano
- The mitochondrial fusion protein Opa1 promotes adipose tissue browning via the chromatin remodeling protein Kdm3
Session 11: Mitochondrial Dynamics and Quality Control
- David Chan
- Mitochondrial fusion is essential for meiosis during spermatogenesis
- Richard Youle
- Synthetic phenotypes in mice lacking PINK1 and Parkin-mediated mitophagy
- Toren Finkel
- Measuring mitophagy and manipulating metabolism
Session 12: Novel Approaches to Mitochondrial Therapy
Chair: Anu Suomalainen University of Helsinki
- Jose Antonio Enriquez
- nDNA/mtDNA intertalk
- Carlos T. Moraes
- Consequences and therapeutic uses of mtDNA double-strand breaks in mammalian cells
- Mary Herbert
- Preventing germline transmission of pathogenic mitochondrial DNA mutations
- Howard Jacobs
- Alternative respiratory enzymes and their potential in therapy