Since it was first observed within cells at the end of the nineteenth century, our bacterial endosymbiont, the mitochondrion, has been interrogated from many perspectives. Initially described as a cytoplasmic structure, then as the source of energy, later an organismal entity, and recently a component of many diseases, the multi-faceted mitochondrion has engendered fascination from a broad spectrum of physical, chemical, biological, and medical perspectives.
What is this cell-within-a-cell? Where did it come from? What is its relevance to our health and well being? How will mitochondrial knowledge affect the future? These are the questions we hope to discuss in this stimulating meeting of modern mitochondriacs who will discuss past, current state and future prospects through their important contributions to the field.
This unique meeting covering the history of mitochondrial research to the latest developments has been preserved and is available for your immediate viewing. PROGRAM contains session topics and links to the full length video and slides of talks presented. PROFILES contains biographies of the people in the field who presented. PARTICIPANTS lists those who attended and their institutions. PHOTOS contain hundreds of candid photos taken during the meeting. SUBMIT YOUR STORY enables meeting participents to add additional recollections about the history of the mitochondrial research field.
Generally regarded as the powerhouse of the cell, mitochondria are eukaryotic organelles that provide a tremendous amount of support to the cell. Originally observed in 1857 by Albert von Kӧlliker, and later termed “bioblasts” by Richard Altman in 1886; these organelles were officially termed “mitochondria” (translated to “thread granules”) by Carl Benda in 1898. Since its early discovery, pioneering research has uncovered that these double-membrane bound organelles are unique in that they contain their own DNA, as well as mediate processes involved in producing cellular energy, regulating cellular metabolism, and controlling cell growth and cell death.
Therefore, understanding the structure and function of this multi-faceted organelle is critical to addressing how dysfunction within the mitochondria can potentially regulate mitochondria-induced pathogenesis. The implication that mitochondria dysfunction is involved in such disease states as diabetes, cancer, neurodegeneration, mitochondrial diseases, and neuropathy; means that the better we can assess the dynamics of basic mitochondrial function and mitochondria-induced disease states, the better we can identify potential therapeutic applications.
This meeting is the eigth in a series organized by the CSHL Meeting and Courses Department together with CSHL Center for Humanities Studies of Modern Biology: Culture, History, Art, and Humanity. We have invited speakers who made many of the seminal discoveries that began the field, as well as those who are working in the field now. We also invite historians who have examined the scientific and societal context of the field. Like the previous meetings in the series, this meeting will provide an excellent opportunity to look in depth at a topic and to share the stories that are often missing from academic accounts.
Previous meetings in the series include: