Brains and Behavior: Order and Disorder in the Nervous System

Symposium Participants v Foreword xv Psychiatric Neuroscience Challenges and Opportunities in Psychiatric Neuroscience Joshua A. Gordon, Julie A. Frost Bellgowan, Collene Lawhorn, and Rachel B. Scheinert 1 The Neurobiology of Confidence: From Beliefs to Neurons Torben Ott, Paul Masset, and Adam Kepecs 9 Casual Inference on Pathophysiological Mediators in Psychiatry Ho Namkung, Brian J. Lee, and Akira Sawa 17 Neurodevelopment and Synapses Parvalbumin Interneuron Plasticity for Consolidation of Reinforced Learning Matteo Tripodi, Komal Bhandari, Ananya Chowdhury, Arghya Mukherjee, and Pico Caroni 25 Adolescence and “Late Blooming” Synapses of the Prefrontal Cortex Kristen Delevich, A. Wren Thomas, and Linda Wilbrecht 37 The Synaptomic Theory of Behavior and Brain Disease Seth G.N. Grant 45 Sleep and Neuromodulation Genetic Mechanisms Underlying Sleep Hirofumi Toda, Mi Shi, Julie A. Williams, and Amita Sehgal 57 Brain Circuitry for Arousal from Apnea Clifford B. Saper and Satvinder Kaur 63 Computational Underpinnings of Neuromodulation in Humans P. Read Montague and Kenneth T. Kishida 71 Multiple Dopamine Systems: Weal and Woe of Dopamine Mitsuko Watabe-Uchida and Naoshige Uchida 83 Social Behavior Neuropeptidergic Control of an Internal Brain State Produced by Prolonged Social Isolation Stress Moriel Zelikowsky, Keke Ding, and David J. Anderson 97 The Hippocampus and Social Impairment in Psychiatric Disorders Matthew Schafer and Daniela Schiller 105 Nucleus Accumbens Modulation in Reward and Aversion Anna M. Klawonn and Robert C. Malenka 119 Neurological Health Epigenetic Priming in Drug Addiction Philipp Mews, Deena M. Walker, and Eric J. Nestler 131 Decoding Depression: Insights from Glial and Ketamine Regulation of Neuronal Burst Firing in Lateral Habenula Yihui Cui, Yan Yang, Yiyan Dong, and Hailan Hu 141 Improving Mouse Models for Dementia. Are All the Effects in Tau Mouse Models Due to Overexpression? Zelah Joel, Pablo Izquierdo, Dervis A. Salih, Jill C. Richardson, Damian M. Cummings, and Frances A. Edwards 151 Distinct Conformers of Assembled Tau in Alzheimer’s and Pick’s Diseases Michel Goedert, Benjamin Falcon, Wenjuan Zhang, Bernardino Ghetti, and Sjors H.W. Scheres 163 Treatments Rewiring the Addicted Brain: Circuits-Based Treatment for Addiction Graziella Madeo and Antonello Bonci 173 Investigating the Therapeutic Mechanism of Cannabidiol in a Human Induced Pluripotent Stem Cell (iPSC)-Based Model of Dravet Syndrome Yishan Sun and Ricardo E. Dolmetsch 185 A Network Explanation of Alzheimer’s Regional Vulnerability Scott A. Small and Larry W. Swanson 193 Current Status of Deep Brain Stimulation for Alzheimer’s Disease: From Chance Observation to Clinical Trials Darrin J. Lee and Andres M. Lozano 201 Benefits of Enhancing Nicotinamide Adenine Dinucleotide Levels in Damaged or Diseased Nerve Cells Andrew A. Pieper and Steven L. McKnight 207 Summary Order and Disorder in Brains and Behavior Adam Kepecs 219 Dorcas Cummings Lecture 227 P. Read Montague 229 Conversations at the Symposium 237 Edward Boyden 239 Yang Dan 243 Ricardo Dolmetsch 246 Paul Glimcher 249 Michel Goedert 252 Joshua A. Gordon 255 Adam Kepecs 258 Robert C. Malenka 261 Helen Mayberg 264 P. Read Montague 268 Michael Platt 272 Daniela Schiller 275 Scott Small 277 Beth Stevens 280 Li-Huei Tsai 284 Kay Tye 287 Mehmet Faith Yanik 290 Huda Zoghbi 293 Author Index 297 Subject 299