Chromosome Segegation and Stucture

Symposium Participants v Foreword xv Chromatin, Histones, and Instability Shaping Chromatin in the Nucleus: The Bricks and the Architects David Sitbon, Katrina Podsypanina, Tejas Yadav, and Genevie`ve Almouzni 1 The Importance of Satellite Sequence Repression for Genome Stability Peter Seller and Susan M. Gasser 15 Structure and Epigenetic Regulation of Chromatin Fibers Ping Chen and Guohong Li 25 Chromosome Biology and Genome Architecture The Role of Bromodomain and Extraterminal Motif (BET) Proteins in Chromatin Structure Sarah C. Hsu and Gerd A. Blobel 37 Emerging Evidence of Chromosome Folding by Loop Extrusion Geoffrey Fudenberg, Nezar Abdennur, Maxim Imakaev, Anton Goloborodko, and Leonid A. Mirny 45 SpotLearn: Convolutional Neural Network for Detection of Fluorescence In Situ Hybridization (FISH) Signals in High-Throughput Imaging Approaches Prabhakar R. Gudla, Koh Nakayama, Gianluca Pegoraro, and Tom Misteli 57 Centromeres and Kinetochores Remarkable Evolutionary Plasticity of Centromeric Chromatin Steven Henikoff, Jitendra Thakur, Sivakanthan Kasinathan, and Paul B. Talbert 71 Molecular Structures of Yeast Kinetochore Subcomplexes and Their Roles in Chromosome Segregation Simon Jenni, Yoana N. Dimitrova, Roberto Valverde, Stephen M. Hinshaw, and Stephen C. Harrison 83 Aurora A Kinase Function at Kinetochores Jennifer G. DeLuca 91 RotoStep: A Chromosome Dynamics Simulator Reveals Mechanisms of Loop Extrusion Josh Lawrimore, Brandon Friedman, Ayush Doshi, and Kerry Bloom 101 Taming the Beast: Control of APC/CCdc20-Dependent Destruction Pablo Lara-Gonzalez, Taekyung Kim, and Arshad Desai 111 Organizing Chromosomes during Segregation Noncanonical Biogenesis of Centrioles and Basal Bodies Catarina Nabais, So ́nia Gomes Pereira, and Mo ́nica Bettencourt-Dias 123 Impact of Centrosome Aberrations on Chromosome Segregation and Tissue Architecture in Cancer Erich A. Nigg, Dominik Schnerch, and Olivier Ganier 137 The ABCs of Centriole Architecture: The Form and Function of Triplet Microtubules Jennifer T. Wang and Tim Stearns 145 Mitotic Chromosome Assembly In Vitro: Functional Cross Talk between Nucleosomes and Condensins Keishi Shintomi and Tatsuya Hirano 157 Mitosis and Cell Cycle Spindle-to-Cortex Communication in Cleaving Frog Eggs Timothy J. Mitchison and Christine M. Field 165 Nucleosome-Dependent Pathways That Control Mitotic Progression Hironori Funabiki, Christopher Jenness, and Christian Zierhut 173 Knotty Problems during Mitosis: Mechanistic Insight into the Processing of Ultrafine DNA Bridges in Anaphase Kata Sarlo ́s, Andreas Biebricher, Erwin J.G. Petermann, Gijs J.L. Wuite, and Ian D. Hickson 187 Low-Level, Global Transcription during Mitosis and Dynamic Gene Reactivation during Mitotic Exit Katherine C. Palozola, Hong Liu, Dario Nicetto, and Kenneth S. Zaret 197 Genome Instability as a Consequence of Defects in the Resolution of Recombination Intermediates Stephen C. West and Ying Wai Chan 207 Meiosis Reconstitution of Female Germ Cell Fate Determination and Meiotic Initiation in Mammals So I. Nagaoka and Mitinori Saitou 213 Regulation of Crossover Frequency and Distribution during Meiotic Recombination Takamune T. Saito and Monica P. Colaia ́covo 223 Oocyte Quality Control: Causes, Mechanisms, and Consequences Neil Hunter 235 Cellular and Molecular Mechanisms of Centromere Drive Michael A. Lampson and Ben E. Black 249 Hierarchical Regulation of Centromeric Cohesion Protection by Meikin and Shugoshin during Meiosis I Seira Miyazaki, Jihye Kim, Takeshi Sakuno, and Yoshinori Watanabe 259 Germ Cells, Imprinting, Gene Dosage, and Regulation Topologically Associating Domains in Chromosome Architecture and Gene Regulatory Landscapes during Development, Disease, and Evolution Rafael Galupa and Edith Heard 267 Dynamic Control of Chromosome Topology and Gene Expression by a Chromatin Modification Qian Bian, Erika C. Anderson, Katjusˇa Brejc, and Barbara J. Meyer 279 Polytene Chromosome Structure and Somatic Genome Instability Allan C. Spradling 293 Heterochromatin, Errors, And Damage Symmetry from Asymmetry or Asymmetry from Symmetry? Elizabeth W. Kahney, Rajesh Ranjan, Ryan J. Gleason, and Xin Chen 305 Function of Junk: Pericentromeric Satellite DNA in Chromosome Maintenance Madhav Jagannathan and Yukiko M. Yamashita 319 Homologous Recombination and Replication Fork Protection: BRCA2 and More! Weiran Feng and Maria Jasin 329 Fork Protection and Therapy Resistance in Hereditary Breast Cancer Sharon B. Cantor and Jennifer A. Calvo 339 Summary How the Genome Folds, Divides, Lives, and Dies Whitney L. Johnson, Kathleen T. Xie, Mijung Kwon, Shiwei Liu, and David Pellman 349 Dorcas Cummings Lecture 361 David Page 363 Conversations at the Symposium 367 Marisa Bartolomei 369 Mo ́nica Bettencourt-Dias 372 Kerry Bloom 375 Iain Cheeseman 378 Monica P. Colaia ́covo 381 Bernard de Massy 384 Arshad Desai 386 Daniel Durocher 389 Steve Henikoff 391 Martin Hetzer 394 Ian Hickson 397 Maria Jasin 400 Leonid Mirny 403 Timothy Mitchison 406 Tim Stearns 409 Aaron Straight 413 Yukiko Yamashita 416 Author Index 419 Subject Index 421