Immunity and Tolerance

Symposium Participants v Foreword xv

Development and Antigen Receptor Gene Assembly

TET Proteins and 5-Methylcytosine Oxidation in the Immune System Ageliki Tsagaratou and Anjana Rao 1 Control of Antigen Receptor Diversity through Spatial Regulation of V(D)J Recombination Anja Ebert, Jasna Medvedovic, Hiromi Tagoh, Tanja A. Schwickert, and Meinrad Busslinger 11 Establishment and Maintenance of B Cell Identity Rudolf Grosschedl 23 Transcriptional Establishment of Cell-Type Identity: Dynamics and Causal Mechanisms of T-Cell Lineage Commitment Ellen V. Rothenberg, Ameya Champhekar, Sagar Damle, Marissa Morales Del Real, Hao Yuan Kueh, Long Li, and Mary A. Yui 31 The Epigenetics of Early Lymphocyte Development C. Murre 43

Gene Regulation

Regnase-1, a Ribonuclease Involved in the Regulation of Immune Responses Shizuo Akira 51 Toward an Understanding of the Gene-Specific and Global Logic of Inducible Gene Transcription Stephen T. Smale, Scott E. Plevy, Amy S.Weinmann, Liang Zhou, Vladimir R. Ramirez-Carrozzi, Scott D. Pope, Dev M. Bhatt, and Ann-Jay Tong 61 Tolerization of Inflammatory Gene Expression John J. Seeley and Sankar Ghosh 69 The “Histone Mimicry” by Pathogens Uwe Schaefer, Jessica S.Y. Ho, Rab K. Prinjha, and Alexander Tarakhovsky 81

Development and Function of Myeloid Subsets

Myb-Independent Macrophages: A Family of Cells That Develops with Their Tissue of Residence and Is Involved in Its Homeostasis Elisa Gomez Perdiguero and Frederic Geissmann 91 The Molecular Choreography of IRF4 and IRF8 with Immune System Partners Harinder Singh, Elke Glasmacher, Abraham B. Chang, and Bryan Vander Lugt 101 The IRF Family Transcription Factors at the Interface of Innate and Adaptive Immune Responses Hiroaki Ikushima, Hideo Negishi, and Tadatsugu Taniguchi 105

T-Cell Differentiation and Function

IL-1b Strikingly Enhances Antigen-Driven CD4 and CD8 T-Cell Responses S.Z. Ben-Sasson, K. Wang, J. Cohen, and W.E. Paul 117 A Modified Model of T-Cell Differentiation Based on mTOR Activity and Metabolism Jonathan D. Powell, Emily B. Heikamp, Kristen N. Pollizzi, and Adam T. Waickman 125 Novel Tools to Dissect the Dynamic Regulation of TCR Signaling by the Kinase Csk and the Phosphatase CD45 Ying Xim Tan, Julie Zikherman, and Arthur Weiss 131

NK Cells and Innate Lymphoid Cells

Dissection of Signaling in Inflammation: Three Novel Inflammatory Regulators Thorsten Berger, Mary E. Saunders, and Tak W. Mak 141 Tissue-Resident Natural Killer Cells Wayne M. Yokoyama, Dorothy K. Sojka, Hui Peng, and Zhigang Tian 149

Microbial Immunity

Immunology Taught by Human Genetics Jean-Laurent Casanova, Laurent Abel, and Lluis Quintana-Murci 157 Systems Approach to Understand the Immune Response in Tuberculosis: An Iterative Process between Mouse Models and Human Disease Anne O’Garra 173 The Zebrafish Guide to Tuberculosis Immunity and Treatment Lalita Ramakrishnan 179 Microbiota: Host Interactions in Mucosal Homeostasis and Systemic Autoimmunity Randy S. Longman, Yi Yang, Gretchen E. Diehl, Sangwon V. Kim, and Dan R. Littman 193 The Promised Land of Human Immunology Laura F. Su, Arnold Han, Helen M. McGuire, David Furman, Evan W. Newell, and Mark M. Davis 203

Tolerance, TREGS and Inflammasome

Transcriptional Control of Regulatory T-Cell Differentiation Joris van der Veeken, Aaron Arvey, and Alexander Rudensky 215 miR-181 and Metabolic Regulation in the Immune System AdamWilliams, Jorge Henao-Mejia, Christian C.D. Harman, and Richard A. Flavell 223 Encoding Immunological Memory in the Initiation of B-Cell Receptor Signaling Susan K. Pierce and Wanli Liu 231

Tumor Immunology and Genome Stability

Programmed Cell Death 1-Directed Immunotherapy for Enhancing T-Cell Function Koichi Araki, Ben Youngblood, and Rafi Ahmed 239 Immune Surveillance of Unhealthy Cells by Natural Killer Cells Alexandre Iannello and David H. Raulet 249 Studying Epstein–Barr Virus Pathologies and Immune Surveillance by Reconstructing EBV Infection in Mice Tomoharu Yasuda, Tristan Wirtz, Baochun Zhang, Thomas Wunderlich, Marc Schmidt-Supprian, Thomas Sommermann, and Klaus Rajewsky 259

Closing Lecture

Pathogen-Sensing, Regulatory T Cells, and Responsiveness-Tuning Collectively Regulate Foreign- and Self-Antigen Mediated T-Cell Responses William E. Paul, Joshua D. Milner, and Zvi Grossman 265 Author Index 277 Subject Index 279