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 LXXII: Clocks and Rhythms 2007 |
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Symposium Interviews: S. Gary, M. Raff  SYMPOSIUM SYNOPSIS LIST OF PARTICIPANTS CONTENTS OF SYMPOSIUM VOLUME PHOTOGRAPHS PUBLISHED VOLUME  |
Clocks and Rhythms
Symposium Volume LXXII Contents
Symposium Participants v
Foreword xxi
Biological Rhythms Workshop IA: Molecular Basis of Rhythms Generation S.R. Mackey 7
Biological Rhythms Workshop IB: Neurophysiology of SCN Pacemaker Function S.J. Kuhlman 21
Biological Rhythms Workshop IC: Sleep and Rhythms M.Y. Münch, S.W. Cain, and J.F. Duffy 35
A Circadian Clock in Neurospora: How Genes and Proteins Cooperate to Produce a Sustained, Entrainable, and Compensated Biological Oscillator with a Period of about a Day J.C. Dunlap, J.J. Loros, H.V. Colot, A. Mehra, W.J. Belden, M. Shi, C.I. Hong, L.F. Larrondo, C.L. Baker, C.-H. Chen, C. Schwerdtfeger, P.D. Collopy, J.J. Gamsby, and R. Lambreghts 57
A PER/TIM/DBT Interval Timer for Drosophila’s Circadian Clock L. Saez, P. Meyer, and M.W. Young 69
Transcriptional Feedback and Definition of the Circadian Pacemaker in Drosophila and Animals M. Rosbash, S. Bradley, S. Kadener, Y. Li, W. Luo, J.S. Menet, E. Nagoshi, K. Palm, R. Schoer, Y. Shang, and C.-H.A. Tang 75
Genetic and Molecular Analysis of the Central and Peripheral Circadian Clockwork of Mice E.S. Maywood, J.S. O’Neill, A.B. Reddy, J.E. Chesham, H.M. Prosser, C.P. Kyriacou, S.I.H. Godinho, P.M. Nolan, and M.H. Hastings 85
The Multiple Facets of Per2 U. Albrecht, A. Bordon, I. Schmutz, and J. Ripperger 95
Chromatin Remodeling and Circadian Control: Master Regulator CLOCK Is an Enzyme B. Grimaldi, Y. Nakahata, S. Sahar, M. Kaluzova, D. Gauthier, K. Prahm, N. Patel, J. Hirayama, and P. Sassone-Corsi 105
The Ancestral Circadian Clock of Monarch Butterflies: Role in Time-compensated Sun Compass Orientation S.M. Reppert 113
Structure and Function of Animal Cryptochromes N. Öztürk, S.-H. Song, S. Özgür, C.P. Selby, L. Morrison, C. Partch, D. Zhong, and A. Sancar 119
Structure Function Analysis of Mammalian Cryptochromes F. Tamanini, I. Chaves, M.I. Bajek, and G.T.J. van der Horst 133
Posttranscriptional Regulation of Mammalian Circadian Clock Output E. Garbarino-Pico and C.B. Green 145
Biological Clocks and the Coordination Theory of RNA Operons and Regulons J.D. Keene 157
Role of Phosphorylation in the Mammalian Circadian Clock K. Vanselow and A. Kramer 167
Posttranslational Regulation of Neurospora Circadian Clock by CK1a-dependent Phosphorylation C. Querfurth, A. Diernfellner, F. Heise, L. Lauinger, A. Neiss, Ö. Tataroglu, M. Brunner, and T. Schafmeier 177
Posttranslational Control of the Neurospora Circadian Clock J. Cha, G. Huang, J. Guo, and Y. Liu 185
Posttranslational Photomodulation of Circadian Amplitude D.E. Somers, S. Fujiwara, W.-Y. Kim, and S.-S. Suh 193
Principles and Problems Revolving Round Rhythm-related Genetic Variants J.C. Hall, D.C. Chang, and E. Dolezelova 215
Synchronization of the Drosophila Circadian Clock by Temperature Cycles F.T. Glaser and R. Stanewsky 233
What Is There Left to Learn about the Drosophila Clock? J. Blau, F. Blanchard, B. Collins, D. Dahdal, A. Knowles, D. Mizrak, and M. Ruben 243
Genetics and Neurobiology of Circadian Clocks in Mammals S.M. Siepka, S.-H. Yoo, J. Park, C. Lee, and J.S. Takahashi 251
The Biology of the Circadian Ck1e tau Mutation in Mice and Syrian Hamsters: A Tale of Two Species A.S.I. Loudon, Q.J. Meng, E.S. Maywood, D.A. Bechtold, R.P. Boot-Handford, and M.H. Hastings 261
Novel Insights from Genetic and Molecular Characterization of the Human Clock L.J. Ptá?cek, C.R. Jones, and Y.-H. Fu 273
Constant Darkness Is a Mammalian Biological Signal C.C. Lee 287
Entrainment of the Human Circadian Clock T. Roenneberg and M. Merrow 293
Peripheral Clocks: Keeping Up with the Master Clock E. Kowalska and S.A. Brown 301
Physiological Importance of a Circadian Clock Outside the Suprachiasmatic Nucleus K.-F. Storch, C. Paz, J. Signorovitch, E. Raviola, B. Pawlyk, T. Li, and C.J. Weitz 307
Regulation of Circadian Gene Expression in Liver by Systemic Signals and Hepatocyte Oscillators B. Kornmann, O. Schaad, H. Reinke, C. Saini, and U. Schibler 319
The Yeast Metabolic Cycle: Insights into the Life of a Eukaryotic Cell B.P. Tu and S.L. McKnight 339
Complexity of the Neurospora crassa Circadian Clock System: Multiple Loops and Oscillators R.M. de Paula, M.W. Vitalini, R.H. Gomer, and D. Bell-Pedersen 345
The Diurnal Project: Diurnal and Circadian Expression Profiling, Model-based Pattern Matching, and Promoter Analysis T.C. Mockler, T.P. Michael, H.D. Priest, R. Shen, C.M. Sullivan, S.A. Givan, C. McEntee, S.A. Kay, and J. Chory 353
Systems Biology of Mammalian Circadian Clocks H.R. Ueda 365
High-resolution Time Course Analysis of Gene Expression from Pituitary M. Hughes, L. DeHaro, S.R. Pullivarthy, J. Gu, K. Hayes, S. Panda, and J. Hogenesch 381
Nuclear Receptors, Metabolism, and the Circadian Clock X. Yang, K.A. Lamia, and R.M. Evans
Stochastic Phase Oscillators and Circadian Bioluminescence Recordings J. Rougemont and F. Naef 405
Reversible Protein Phosphorylation Regulates Circadian Rhythms D.M. Virshup, E.J. Eide, D.B. Forger, M. Gallego, and E. Vielhaber Harnish 437
Evolution of the Clock from Yeast to Man by Period Doubling Folds in the Cellular Oscillator R.R. Klevecz and C.M. Li 421
Transcriptional Feedback Loop Regulation, Function, and Ontogeny in Drosophila J. Benito, H. Zheng, F.S. Ng, and P.E. Hardin 437
Building the Spine: The Vertebrate Segmentation Clock O. Pourquié 445
Ultradian Oscillators in Somite Segmentation and Other Biological Events R. Kageyama, S. Yoshiura, Y. Masamizu, and Y. Niwa 451
The Role of Circadian Regulation in Cancer S. Gery and H.P. Koeffler 459
Cross-talks between Circadian Timing System and Cell Division Cycle Determine Cancer Biology and Therapeutics F. Lévi, E. Filipski, I. Iurisci, X.M. Li, and P.Innominato 465
The Clock Proteins, Aging, and Tumorigenesis R.V. Kondratov and M.P. Antoch 477
Sirtuins in Aging and Disease L. Guarente 483
Identification of Caenorhabditis elegans Genes Regulating Longevity Using Enhanced RNAi-sensitive Strains A.V. Samuelson, R.R. Klimczak, D.B. Thompson, C.E. Carr, and G. Ruvkun 489
MultiplePhotoreceptors Contribute to Nonimage-forming Visual Functions Predominantly through Melanopsin-containing Retinal Ganglion Cells A.D. Güler, C.M. Altimus, J.L. Ecker, and S. Hattar 509
The Lateral and Dorsal Neurons of Drosophila melanogaster: New Insights about Their Morphology and Function C. Helfrich-Förster, T. Yoshii, C. Wülbeck, E. Grieshaber, D. Rieger, W. Bachleitner, P. Cusumano, and F. Rouyer 517
Exploring Spatiotemporal Organization of SCN Circuits L. Yan, I. Karatsoreos, J. LeSauter, D.K. Welsh, S. Kay, D. Foley, and R. Silver 527
Inducible Clocks: Living in an Unpredictable World C.B. Saper and P.M. Fuller 543
Suprachiasmatic Nucleus Clock Time in the Mammalian Circadian System H. Okamura 551
Neurohormonal and Neuromodulatory Control of Sleep in Drosophila? K. Foltenyi, R. Andretic, J.W. Newport, and R.J. Greenspan 565
Molecular Analysis of Sleep M. Tafti and P. Franken 573
Sleep and Circadian Rhythms in Humans C.A. Czeisler and J.J. Gooley 579
Thermosensitive Splicing of a Clock Gene and Seasonal Adaptation W.-F. Chen, K.H. Low, C. Lim, and I. Edery 599
Endogenous Circannual Clock and HP Complex in a Hibernation Control System N. Kondo 607
On the Chronobiology of Cohabitation M.J. Paul and W.J. Schwartz 615
Melatonin and Human Chronobiology A.J. Lewy 623
A Role for the Clock Gene in Bipolar Disorder C.A. McClung 637
The Possible Interplay of Synaptic and Clock Genes in Autism Spectrum Disorders T. Bourgeron 645
Summary. Circadian Clocks: 50 Years On M. Menaker 655
Foreword xxi
Introduction
Biological Rhythms Workshop I: Introduction to Chronobiology S.J. Kuhlman, S.R. Mackey, and J.F. Duffy 1Biological Rhythms Workshop IA: Molecular Basis of Rhythms Generation S.R. Mackey 7
Biological Rhythms Workshop IB: Neurophysiology of SCN Pacemaker Function S.J. Kuhlman 21
Biological Rhythms Workshop IC: Sleep and Rhythms M.Y. Münch, S.W. Cain, and J.F. Duffy 35
Clockworks
A Cyanobacterial Circadian Clock Based on the Kai Oscillator T. Kondo 47A Circadian Clock in Neurospora: How Genes and Proteins Cooperate to Produce a Sustained, Entrainable, and Compensated Biological Oscillator with a Period of about a Day J.C. Dunlap, J.J. Loros, H.V. Colot, A. Mehra, W.J. Belden, M. Shi, C.I. Hong, L.F. Larrondo, C.L. Baker, C.-H. Chen, C. Schwerdtfeger, P.D. Collopy, J.J. Gamsby, and R. Lambreghts 57
A PER/TIM/DBT Interval Timer for Drosophila’s Circadian Clock L. Saez, P. Meyer, and M.W. Young 69
Transcriptional Feedback and Definition of the Circadian Pacemaker in Drosophila and Animals M. Rosbash, S. Bradley, S. Kadener, Y. Li, W. Luo, J.S. Menet, E. Nagoshi, K. Palm, R. Schoer, Y. Shang, and C.-H.A. Tang 75
Genetic and Molecular Analysis of the Central and Peripheral Circadian Clockwork of Mice E.S. Maywood, J.S. O’Neill, A.B. Reddy, J.E. Chesham, H.M. Prosser, C.P. Kyriacou, S.I.H. Godinho, P.M. Nolan, and M.H. Hastings 85
The Multiple Facets of Per2 U. Albrecht, A. Bordon, I. Schmutz, and J. Ripperger 95
Chromatin Remodeling and Circadian Control: Master Regulator CLOCK Is an Enzyme B. Grimaldi, Y. Nakahata, S. Sahar, M. Kaluzova, D. Gauthier, K. Prahm, N. Patel, J. Hirayama, and P. Sassone-Corsi 105
The Ancestral Circadian Clock of Monarch Butterflies: Role in Time-compensated Sun Compass Orientation S.M. Reppert 113
Structure and Function of Animal Cryptochromes N. Öztürk, S.-H. Song, S. Özgür, C.P. Selby, L. Morrison, C. Partch, D. Zhong, and A. Sancar 119
Structure Function Analysis of Mammalian Cryptochromes F. Tamanini, I. Chaves, M.I. Bajek, and G.T.J. van der Horst 133
Posttranscriptional and Posttranslational Mechanisms
The Gonyaulax Clock at 50: Translational Control of Circadian Expression J.W. Hastings 141Posttranscriptional Regulation of Mammalian Circadian Clock Output E. Garbarino-Pico and C.B. Green 145
Biological Clocks and the Coordination Theory of RNA Operons and Regulons J.D. Keene 157
Role of Phosphorylation in the Mammalian Circadian Clock K. Vanselow and A. Kramer 167
Posttranslational Regulation of Neurospora Circadian Clock by CK1a-dependent Phosphorylation C. Querfurth, A. Diernfellner, F. Heise, L. Lauinger, A. Neiss, Ö. Tataroglu, M. Brunner, and T. Schafmeier 177
Posttranslational Control of the Neurospora Circadian Clock J. Cha, G. Huang, J. Guo, and Y. Liu 185
Posttranslational Photomodulation of Circadian Amplitude D.E. Somers, S. Fujiwara, W.-Y. Kim, and S.-S. Suh 193
Genetics of Rhythms
Circadian Output, Input, and Intracellular Oscillators: Insights into the Circadian Systems of Single Cells J.J. Loros, J.C. Dunlap, L.F. Larrondo, M. Shi, W.J. Belden, V.D. Gooch, C.-H. Chen, C.L. Baker, A. Mehra, H.V. Colot, C. Schwerdtfeger, R. Lambreghts, P.D. Collopy, J.J. Gamsby, and C.I. Hong 201Principles and Problems Revolving Round Rhythm-related Genetic Variants J.C. Hall, D.C. Chang, and E. Dolezelova 215
Synchronization of the Drosophila Circadian Clock by Temperature Cycles F.T. Glaser and R. Stanewsky 233
What Is There Left to Learn about the Drosophila Clock? J. Blau, F. Blanchard, B. Collins, D. Dahdal, A. Knowles, D. Mizrak, and M. Ruben 243
Genetics and Neurobiology of Circadian Clocks in Mammals S.M. Siepka, S.-H. Yoo, J. Park, C. Lee, and J.S. Takahashi 251
The Biology of the Circadian Ck1e tau Mutation in Mice and Syrian Hamsters: A Tale of Two Species A.S.I. Loudon, Q.J. Meng, E.S. Maywood, D.A. Bechtold, R.P. Boot-Handford, and M.H. Hastings 261
Novel Insights from Genetic and Molecular Characterization of the Human Clock L.J. Ptá?cek, C.R. Jones, and Y.-H. Fu 273
Entrainment and Peripheral Clocks
Circadian Entrainment of Neurospora crassa M. Merrow and T. Roenneberg 279Constant Darkness Is a Mammalian Biological Signal C.C. Lee 287
Entrainment of the Human Circadian Clock T. Roenneberg and M. Merrow 293
Peripheral Clocks: Keeping Up with the Master Clock E. Kowalska and S.A. Brown 301
Physiological Importance of a Circadian Clock Outside the Suprachiasmatic Nucleus K.-F. Storch, C. Paz, J. Signorovitch, E. Raviola, B. Pawlyk, T. Li, and C.J. Weitz 307
Regulation of Circadian Gene Expression in Liver by Systemic Signals and Hepatocyte Oscillators B. Kornmann, O. Schaad, H. Reinke, C. Saini, and U. Schibler 319
Systems Approaches to Biological Clocks
Integrating the Circadian Oscillator into the Life of the Cyanobacterial Cell S.S. Golden 331The Yeast Metabolic Cycle: Insights into the Life of a Eukaryotic Cell B.P. Tu and S.L. McKnight 339
Complexity of the Neurospora crassa Circadian Clock System: Multiple Loops and Oscillators R.M. de Paula, M.W. Vitalini, R.H. Gomer, and D. Bell-Pedersen 345
The Diurnal Project: Diurnal and Circadian Expression Profiling, Model-based Pattern Matching, and Promoter Analysis T.C. Mockler, T.P. Michael, H.D. Priest, R. Shen, C.M. Sullivan, S.A. Givan, C. McEntee, S.A. Kay, and J. Chory 353
Systems Biology of Mammalian Circadian Clocks H.R. Ueda 365
High-resolution Time Course Analysis of Gene Expression from Pituitary M. Hughes, L. DeHaro, S.R. Pullivarthy, J. Gu, K. Hayes, S. Panda, and J. Hogenesch 381
Nuclear Receptors, Metabolism, and the Circadian Clock X. Yang, K.A. Lamia, and R.M. Evans
Models
Bacterial Circadian Programs C.H. Johnson 395Stochastic Phase Oscillators and Circadian Bioluminescence Recordings J. Rougemont and F. Naef 405
Reversible Protein Phosphorylation Regulates Circadian Rhythms D.M. Virshup, E.J. Eide, D.B. Forger, M. Gallego, and E. Vielhaber Harnish 437
Evolution of the Clock from Yeast to Man by Period Doubling Folds in the Cellular Oscillator R.R. Klevecz and C.M. Li 421
Development, Proliferation, and Aging
Intracellular Developmental Timers M. Raff 431Transcriptional Feedback Loop Regulation, Function, and Ontogeny in Drosophila J. Benito, H. Zheng, F.S. Ng, and P.E. Hardin 437
Building the Spine: The Vertebrate Segmentation Clock O. Pourquié 445
Ultradian Oscillators in Somite Segmentation and Other Biological Events R. Kageyama, S. Yoshiura, Y. Masamizu, and Y. Niwa 451
The Role of Circadian Regulation in Cancer S. Gery and H.P. Koeffler 459
Cross-talks between Circadian Timing System and Cell Division Cycle Determine Cancer Biology and Therapeutics F. Lévi, E. Filipski, I. Iurisci, X.M. Li, and P.Innominato 465
The Clock Proteins, Aging, and Tumorigenesis R.V. Kondratov and M.P. Antoch 477
Sirtuins in Aging and Disease L. Guarente 483
Identification of Caenorhabditis elegans Genes Regulating Longevity Using Enhanced RNAi-sensitive Strains A.V. Samuelson, R.R. Klimczak, D.B. Thompson, C.E. Carr, and G. Ruvkun 489
Neuroanatomy and Circuits
Circadian Photoreception in Vertebrates S. Doyle and M. Menaker 499MultiplePhotoreceptors Contribute to Nonimage-forming Visual Functions Predominantly through Melanopsin-containing Retinal Ganglion Cells A.D. Güler, C.M. Altimus, J.L. Ecker, and S. Hattar 509
The Lateral and Dorsal Neurons of Drosophila melanogaster: New Insights about Their Morphology and Function C. Helfrich-Förster, T. Yoshii, C. Wülbeck, E. Grieshaber, D. Rieger, W. Bachleitner, P. Cusumano, and F. Rouyer 517
Exploring Spatiotemporal Organization of SCN Circuits L. Yan, I. Karatsoreos, J. LeSauter, D.K. Welsh, S. Kay, D. Foley, and R. Silver 527
Inducible Clocks: Living in an Unpredictable World C.B. Saper and P.M. Fuller 543
Suprachiasmatic Nucleus Clock Time in the Mammalian Circadian System H. Okamura 551
Sleep, Seasons, and Mood
Molecular Analysis of Sleep:Wake Cycles in Drosophila A. Sehgal, W. Joiner, A. Crocker, K. Koh, S. Sathyanarayanan, Y. Fang, M. Wu, J.A. Williams, and X. Zheng 557Neurohormonal and Neuromodulatory Control of Sleep in Drosophila? K. Foltenyi, R. Andretic, J.W. Newport, and R.J. Greenspan 565
Molecular Analysis of Sleep M. Tafti and P. Franken 573
Sleep and Circadian Rhythms in Humans C.A. Czeisler and J.J. Gooley 579
Thermosensitive Splicing of a Clock Gene and Seasonal Adaptation W.-F. Chen, K.H. Low, C. Lim, and I. Edery 599
Endogenous Circannual Clock and HP Complex in a Hibernation Control System N. Kondo 607
On the Chronobiology of Cohabitation M.J. Paul and W.J. Schwartz 615
Melatonin and Human Chronobiology A.J. Lewy 623
A Role for the Clock Gene in Bipolar Disorder C.A. McClung 637
The Possible Interplay of Synaptic and Clock Genes in Autism Spectrum Disorders T. Bourgeron 645
Summary. Circadian Clocks: 50 Years On M. Menaker 655
Author Index 661
Subject Index 663
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