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Function & Dysfunction in the Nervous SystemSymposium Volume LXI Contents
Symposium Participants v
Foreword xvii Language and Visual Processing Cortical Plasticity Underlying Perceptual, Motor, and Cognitive Skill Development: Implications for Neurorehabilitation M.M. Merzenich, B. Wright, W. Jenkins, C. Xerri, N. Byl, S. Miller, and P. Tallal 1 What Words Are Telling Us about the Brain M.E. Raichle 9 Neural Mechanisms for Heading and Structure-from-motion Perception R.A. Andersen, D.C. Bradley, and K.V. Shenoy 15 Visual Responses in Vl of Freely Viewing Monkeys M.S. Livingstone, D.C. Freeman, and D.H. Hubel 27 Amblyopia: A Developmental Disorder of the Central Visual Pathways L. Kiorpes and J.A. Movshon 39 The Functional Anatomy of Visual Awareness C. Koch and J. Braun 49 Handedness A Single Locus, RGHT, Specifies Preference for Hand Utilization in Humans A.J.S. Klar 59 Perceptual Plasticity Functions and Roles of Glutamate Receptors in Synaptic Transmission and Plasticity S. Nakanishi, Y. Nakajima, A. Nomura, M. Masu, H. Iwakabe, Y. Hayashi, and M. Yokoi 67 Combination of Gene Targeting and Gene Transfer by Adenoviral Vectors in the Analysis of Neurotrophin-mediated Neuronal Plasticity O. Griesbeck, M. Korte, V. Staiger, C. Gravel, P. Carroll, T. Bonhoeffer, and H. Thoenen 77 Neurotrophins in Cortical Development D.R. Riddle, A.K. McAllister, D.C. Lo, and L.C. Katz 85 In Vivo Development of Neuronal Structure and Function H. T. Cline, G.-Y. Wu, and R. Malinow 95 Cortical Dynamics and Visual Perception C.D. Gilbert, A. Das, M.K. Ito, M.K. Kapadia, and G. Westheimer 105 What Neurological Syndromes Can Tell Us about Human Nature: Some Lessons from Phantom Limbs, Capgras Syndrome, and Anosognosia V.S. Ramachandran 115 Sensory Perception The Molecular Biology of Olfactory Perception P. Mombaerts, F. Wang, C. Dulac, R. Vassar, S.K. Chao, A. Nemes, M. Mendelsohn, J. Edmondson, and R. Axel 135 Information Coding in the Mammalian Olfactory System L.B. Buck 147 Olfactory Recognition and Discrimination in Caenorhabditis elegans J.H. Chou, E.R. Troemel, P. Sengupta, H.A. Colbert, L. Tong, D.M. Tobin, K. Roayaie, J.G. Crump, N.D. Dwyer, and C.I. Bargmann 157 Genetic Approaches to Mammalian Olfaction R.R. Reed 165 Biochemical and Transgenic Analysis of Gustducin's Role in Bitter and Sweet Transduction G. T. Wong, L. Ruiz-Avila, D. Ming, K.S. Gannon, and R.F. Margolskee 173 Memory . Memory, Memory Impairment, and the Medial Temporal Lobe L.R. Squire and S.M. Zola 185 Nueral Mechanisms of Declrative Memory H. Eichenbaum, J. Dusek, B. Young, and M. Bunsey 197 A Return to Genetic Dissection of Memory in Drosophila T. Tully, G. Bolwig, J. Christensen, J. Connolly, M. DelVecchio, J. DeZazzo, J. Dubnau, C. Jones, S. Pinto, M. Regulski, B. Svedberg, and K. Velinzon 207 CaMKII Function in the Nervous System Explored from a Genetic Perspective M. Mayford, M.E. Bach, and E.R. Kandel 219 Hippocampal CA1-region-restricted Knockout of NMDARl Gene Disrupts Synaptic Plasticity, Place Fields, and Spatial Learning S. Tonegawa, J.Z. Tsien, T.J. McHugh, P. Huerta, K.I. Blum, and M.A. Wilson 225 Genetic Analysis of Function and Dysfunction in the Central Nervous System A.J. Silva, N. Fedorov, J. Kogan, P. Frankland, J. Coblentz, R. Lundsten, E. Friedman, A. Smith, Y. Cho, and K. P. Giese 239 Emotional Memory: A Search for Sites of Plasticity G.J. Quirk, J.L. Armony, J.C. Repa, X.-F. Li, and J.E. LeDoux 247 Neurobiology of Memory for Emotional Events: Converging Evidence from Infrahuman and Human Studies L. Cahill 259 Rhythms A Drosophila Circadian Clock M. Rosbash, R. Allada, M. Dembinska, W.Q. Guo, M. Le, S. Marrus, Z. Qian, J.E. Rutila, J. Yaglom, and H. Zeng 265 Molecular Anatomy of a Light-sensitive Circadian Pacemaker in Drosophila M. W. Young, K. Wager-Smith, L. Vosshall, L. Saez, and M.P. Myers 279 Rhythmic Transcription and Autoregulatory Loops: Nuclear Pacemaker CREM M. Lamas, E. Lalli, N.S. Foulkes, and P. Sassone-Corsi 285 Forward Genetic Approaches to Circadian Clocks in Mice D.P. King and J.S. Takahashi 295 Channels and Receptors Confocal-microscopic Visualization of Membrane Addition during Synaptic Exocytosis at Presynaptic Active Zones of Hair Cells A.J. Hudspeth and N.P. Issa 303 Multiple Myosin Isozymes and Hair-cell Function P.G. Gillespie, T. Hasson, J.A. Garcia, and D.P. Corey 309 Molecular and Cellular Plasticity in Developing Epileptic Brain J.L. Noebels, M.L. Sutherland, W.K. Nahm, and E. DiPasquale 319 Glutamate Receptor Autoimmunity in Rasmussen's Encephalitis J.D. McNamara, M. Patel, X.-P. He, S. Janumpalli, and K.D. Whitney 327 Molecular and Genetic Insights into Ligand Binding and Signal Transduction at the Inhibitory Glycine Receptor P.R. Schofield, J.W. Lynch, S. Rajendra, K.D. Pierce, C.A. Handford, and P.H. Barry 333 Nicotinic Receptors and Brain Plasticity J.-P. Changeux, A. Bessis, J.-P. Bourgeois, P.-J. Corringer, A. Devillers-Thiery, J.-L. Eisele, M. Kerszberg, C. Lena, N. Le Novere, M. Picciotto, and M. Zoli 343 The Nicotinic Acetylcholine Receptor at the Neuromuscular Junction: Assembly and Tyrosine Phosphorylation Z.-Z. Wang, C. Fuhrer, S. Shtrom, J.E. Sugiyama, M.J. Ferns, and Z.W. Hall 363 The GluR2 Hypothesis: Ca++-permeable AMPA Receptors in Delayed Neurodegeneration M.V.L. Bennett, D.E. Pellegrini-Giampietro, J.A. Gorter, E. Aronica, J.A. Connor, and R.S. Zukin 373 Neuronal Survival and Signaling Zinc Neurotoxicity May Contribute to Selective Neuronal Death following Transient Global Cerebral Ischemia D.W. Choi 385 A Signaling Endosome Hypothesis to Explain NGF Actions: Potential Implications for Neurodegeneration E.C. Beattie, J. Zhou, M.L. Grimes, N. W. Bunnett, C.L. Howe, and W.C. Mobley 389 Neurotrophins and Their p75 Receptor B.D. Carter, G. Dechant, J.M. Frade, C. Kaltschmidt, and Y.-A. Barde 407 Nitric Oxide, Cell Multiplication, and Cell Survival N. Peunova, B. Kuzin, I. Roberts, C. O'Kane, and G. Enikolopov 417 The Role of Neuregulin (ARIA) at the Neuromuscular Junction K.M. Rosen, A. W. Sandrock, Jr., A.D.J. Goodearl, J.A. Loeb, and G.D. Fischbach 427 The Receptor Tyrosine Kinase MuSK Is Required for Neuromuscular Junction Formation and Is a Functional Receptor for Agrin D.J. Glass, T.M. DeChiara, T.N. Stitt, P.S. DiStefano, D.M. Valenzuela, and G.D. Yancopoulos 435 GDNF Is Required for Kidney Development and Enteric Innervation J.G. Pichel, L. Shen, H.Z. Sheng, A.-C. Granholm, J. Drago, A. Grinberg, E.J. Lee, S.P. Huang, M. Saarma, B.J. Hoffer, H. Sariola, and H. Westphal 445 Neuregulins as Potential Drugs for Neurological Disorders M.A. Marchionni, C.J. Kirk, I.J. Isaacs, C.J. Hoban, N.K. Mahanthappa, E.S. Anton, C. Chen, F. Wason, D. Lawson, F.P. T. Hamers, P.D. Canoll, R. Reynolds, B. Cannella, D. Meun, W.F. Holt, W.D. Matthew, L.-E. Chen, W.H. Gispen, C.S. Raine, J.L. Salzer, and D.I. Gwynne 459 Prions Molecular Biology and Genetics of Prion Diseases S.B. Prusiner 473 Prion Protein Structure and Scrapie Replication: Theoretical, Spectroscopic, and Genetic Investigations P. Bamborough, H. Wille, G.C. Telling, F. Yehiely, S.B. Prusiner, and F.E. Cohen 495 The Role of PrP in Pathogenesis of Experimental Scrapie C. Weissmann, M. Fischer, A. Raeber, H. Bueler, A. Sailer, D. Shmerling, T. Rulicke, S. Brandner, and A. Aguzzi 511 A New Variant of Creutzfeldt-Jakob Disease: Neuropathological and Clinical Features J.W. Ironside, K. Sutherland, J.E. Bell, L. McCardle, C. Barrie, K. Estebeiro, M. Zeidler, and R.C. Will 523 Abnormal Plasma Membrane Properties and Functions in Prion-infected Cell Lines S.J. DeArmond, Y. Qiu, K. Wong, R. Nixon, W. Hyun, S.B. Prusiner, and W.C. Mobley 531 Prions of Yeast, [PSI] and [URE3], as Models for Neurodegenerative Diseases R.B. Wickner, D.C. Masison, H.K. Edskes, and M.-L. Maddelein 541 Alzheimer's Disease The Role of Presenilin 1 in the Genetics of Alzheimer's Disease R.F. Clark, M. Hutton, C. Talbot, M. Wragg, C. Lendon, F. Busfield, S.W. Han, J. Perez-Tur, M. Adams, R. Fuldner, G. Roberts, E. Karran J.Hardy, and A. Goate 551 Two Homologous Genes Causing Early-onset Familial Alzheimer's Disease P.H. St. George-Hyslop, C. Levesque, L. Levesque, J. Rommens, D. Westaway, and P.E. Fraser 559 Molecular Dissection of the Neurofibrillary Lesions of Alzheimer's Disease M. Goedert, M.G. Spillantini, M. Hasegawa, R. Jakes, R.A. Crowther, and A. Klug 565 Neuronal Sorting and Processing of Amyloid Precursor Protein: Implications for Alzheimer's Disease P.J. Tienari, B. De Strooper, E. Ikon en, N. Ida, M. Simons, C.L. Masters C.G. Dotti, and K. Beyreuther 575 Cell Biology of the b-Amyloid Precursor Protein and the Genetics of Alzheimer's Disease D.J. Selkoe 587 Protein:Protein Interactions in Alzheimer's Disease and the CAG Triplet Repeat Diseases W.J. Strittmatter, J.R. Burke, V.S. DeSerrano, D.Y. Huang, W. Matthew, A.M. Saunders, B.L. Scott, J.M. Vance, K.H. Weisgraber, and A.D. Roses 597 Neurodegenerative Diseases Myotonic Dystrophy: Discussion of Molecular Mechanism C.T. Caskey, M.S. Swanson, and L. T. Timchenko 607 Huntington's Disease J.F. Gusella, S. McNeil, F. Persichetti, J. Srinidhi, A. Novelletto, E. Bird, P. Faber, J.-P. Vonsattel, R.H. Myers, and M.E. MacDonald 615 Targeted Inactivation of the Mouse Huntington's Disease Gene Homolog Hdh M.E. MacDonald, M. Duyao, T. Calzonetti, A. Auerbach, A. Ryan, G. Barnes,J.K. White, W. Auerbach, J.-P. Vonsattel, J.F. Gusella, and A.L. Joyner 627 Polyglutamine Expansions and Neurodegenerative Diseases F. Saudou, D. Devys, Y. Trottier, G. 1mbert, M.-E. Stoeckel, A. Brice, and J.-L. Mandel 639 Toward Understanding Polyglutamine-induced Neurological Disease in Spinocerebellar Ataxia Type 1 H.T. Orr and H.Y. Zoghbi 649 Molecular Mechanisms for Charcot-Marie- Tooth Disease and Related Demyelinating Peripheral Neuropathies L.E. Warner, L.T. Reiter, T. Murakami, and J.R. Lupski 659 Connexin32 and X-linked Charcot-Marie- Tooth Disease K.H. Fischbeck, S.M. Deschenes, L.J. Bone, and S.S. Scherer 673 The Molecular Basis of Fragile X Syndrome D.E. Eberhart and S.T. Warren 679 Molecular Characterization of the Protein Products of the Fragile X Syndrome Gene and the Survival of Motor Neurons Gene Q. Liu, H. Siomi, M.C. Siomi, U. Fischer, Y. Zhang, L. Wan, and G. Dreyfuss 689 ALS: Molecular Clues to the Jigsaw Puzzle of Neuronal Degeneration T. Siddique 699 Neurofilaments, Radial Growth of Axons, and Mechanisms of Motor Neuron Disease T.L. Williamson, J.R. Marszalek, J.D. Vechio, L.I. Bruijn, M.K. Lee, Z. Xu, R.H. Brown, Jr., and D.W. Cleveland 709 Neurodegenerative Diseases and Model Systems D.L. Price, D.R. Borchelt, P.C. Wong, C.A. Pardo, G. Thinakaran, M.K. Lee, D.W. Cleveland, and S.S. Sisodia 725 Extracellular Proteases in Neuronal Function and Degeneration S. Strickland, A. Gualandris, A.D. Rogove, and S.E. Tsirka 739 Molecular Analysis of Neurotransmitter Transport into Secretory Vesicles Y. Liu, C. Waites, D. Krantz, P. Tan, and R.H. Edwards 741 Dementia, Addiction, and Psychiatric Diseases AIDS Dementia Complex: A Complex, Slow Virus "Model" of Acquired Genetic Neurodegenerative Disease R.W. Price 759 Quantitative Trait Loci Mapping in Mouse Models of Complex Behavior T.N. Ferraro and W.H. Berrettini 771 Recent Developments in the Genetics of Bipolar Disorder J.R. DePaulo, Jr. and F.J. McMahon 783 The Serotonin Transporter Gene and Affective Disorder A.J. Harmar, A.D. Ogilvie, S. Battersby, C.A.D. Smith, D.H.R. Blackwood, W.J. Muir, G. Fink, and G.M. Goodwin 791 The Johns Hopkins University Collaborative Schizophrenia Study: An Epidemiologic- Genetic Approach to Test the Heterogeneity Hypothesis and Identify Schizophrenia Susceptibility Genes A.E. Pulver, P.S. Wolyniec, D. Housman, H.H. Kazazian, S.E. Antonarakis, G. Nestadt, V.K. Lasseter, J.A. McGrath, B. Dombroski, M. Karayiorgou, C. Ton, J.-L. Blouin, and L. Kempf 791 Molecular Genetic Studies of Schizophrenia P. McGuffin and M.J. Owen 815 Support for Schizophrenia Vulnerability Loci on Chromosomes 6p and 8p from Irish Families R.E. Straub, C.J. MacLean, D. Walsh, and K.S. Kendler 823 Genotype and Phenotype Analysis at the 22q11 Schizophrenia Susceptibility Locus M. Karayiorgou, J.A. Gogos, B.L. Galke, J.A. Jeffery, G. Nestadt, P.S. Wolyniec, S.E. ntonarakis, H.H. Kazazian, D.E. Housman, D.A. Driscoll, and A.E. Pulver 835 Searching for Susceptibility Genes in Schizophrenia by Genetic Linkage Analysis D.B. Wildenauer, J. Hallmayer, S.G. Schwab, M. Albus, G.N. Eckstein, P. Zill, S. Hönig, M. Strauss, M. Borrmann, D. Lichtermann, R.P. Ebstein, B. Lerer, N. Risch, and W. Maier 845 Summary: Function and Dysfunction of the Nervous System Z.W. Hall 851 |
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