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 LIX: The Molecular Genetics of Cancer 1994 |
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From left: Dr. Gordon Peters, Dr. Jan Witkowski, Dr. J. Michael Bishop, Dr. Carol Greider  SYMPOSIUM SYNOPSIS LIST OF PARTICIPANTS CONTENTS OF SYMPOSIUM VOLUME PHOTOGRAPHS PUBLISHED VOLUME  |
The Molecular Genetics of Cancer
Symposium Volume LIX Contents
Control of Cell Cycle and Cell Growth
The Cancer Cell and the Cell Cycle Clock M. Hatakeyama, R.A. Herrera, T. Makela, S.F. Dowdy, T. Jacks, and R.A. Weinberg 1
D-type Cyclins and Their Cyclin-dependent Kinases: G1 Phase Integrators of the Mitogenic Response C.J. Sherr, J. Kato, D.E. Quelle, M. Matsuoka, and M.F. Roussel 11
p21 Is a Component of Active Cell Cycle Kinases H. Zhang, G.J. Hannon, D. Casso, and D. Beach 21
Cyclins, Cdks,, and Cyclin Kinase Inhibitor J.M. Roberts, A. Koff, K. Polyak, E. Firpo, S. Collins, M. Ohtsubo, and J. Massagué 31
Role of a Cell Cycle Regulator in Hereditary and Sporadic Cancer A. Kamb 39
p16INK4 Mutations and Altered Expression in Human Tumors and Cell Lines A. Okamoto, D.J. Demetrick, E.A. Spillare, K. Hagiwara, S.P. Hussain, W.P. Bennett, K. Forrester, B. Gerwin, M.S. Greenblatt, M. Serrano, M. Shiseki, J. Yokota, D.H. Beach, and C.C. Harris 49
Molecular Genetic Approaches to the Study of Cellular Senescence T.J. Goletz, J.R. Smith, and O.M. Pereira-Smith 59
Molecular and Cell Biology of Replicative Senescence G.P. Dimri and J. Campisi 67
Growth Suppression by Members of the Retinoblastoma Protein Family L. Zhu, G.H. Enders, C.-L. Wu, M.A. Starz, K.H. Moberg, J.A. Lees, N. Dyson, and E. Harlow 75
The Adenovirus E1A-associated 300-kD Protein Exhibits Properties of a Transcriptional Coactivator and Belongs to an Evolutionarily Conserved Family R. Eckner, Z. Arany, M. Ewen, W. Sellers, and D.M. Livingston 85
The Corral Hypothesis: A Novel Regulatory Mode for Retinoblastoma Protein Function W.-H. Lee, Y. Xu, F. Hong, T. Durfee, M.A. Mancini, Y. Ueng, P.-L. Chen, and D. Riley 97
The Max Transcription Factor Network: Involvement of Mad in Differentiation and an Approach to Identification of Target Genes P. Hurlin, D.E. Ayer, C. Grandori, and R.N. Eisenman 109
BCL-6 and the Molecular Pathogenesis of B-cell Lymphoma R. Dalla-Favera, B.H. Ye, F. Lo Coco, C.C. Chang, K. Cechova, J. Zhang, A. Migliazza, W. Mellado, H. Niu, S. CHaganti, K. Offit, W. Chen, P.H. Rao, N.Z. Parsa, D.C. Louie, and R.S.K. Chaganti 117
Functional Analysis of the TAN-1 Gene, a Human Homolog of Drosophila Notch J. Aster, W. Pear, R. Hasserjian, H. Erba, F. Davi, B. Luo, M. Scott, D. Baltimore, and J. Sklar 125
Novel Oncogenic Mutations in the WT1 Wilms' Tumor Suppressor Gene: A t(11;22) Fuses the Ewing's Sarcoma Gene, EWS1 to WT1 in Desmoplastic Small Round Cell Tumor F.J. Rauscher III, L.E. Benjamin, W.J. Fredericks, and J.F. Morris 137
Ras Signal Transduction Pathway in Drosophila Eye Development H.C. Chang, F.D. Karim, E.M. O'Neill, I. Rebay, N.M. Solomon, M. Therrien, D.A. Wassarman, T. Wolff, and G.M. Rubin 147
Molecular Genetics of Protooncogenes and Candidate Tumor Suppressors in Caenorhabditis elegans P.W. Sternberg, C.H. Yoon, J. Lee, G.D. Jongeward, P.S. Kayne, W.S. Katz, G. Lesa, J. Liu, A. Golden, L.S. Huang, and H.M. Chamberlin 155
Proto-oncogenes and Plasticity in Cell Signaling J.M. Bishop, A.J. Capobianco, H.J. Doyle, R.E. Finney, M. McMahon, S.M. Robbins, M.L. Samuels, and M. Vetter 165
Activation of Ras and Other Signaling Pathways by Receptor Tyrosine Kinases J. Schlessinger and D. Bar-Sagi 173
Ras Partners L. Van Aelst, M. White, and M.H. Wigler 181
Proteins of the 14-3-3 Family Associate with Raf and Contribute to Its Activation E. Freed, F. McCormick, and R. Ruggieri 187
Regulation of the Cryptic Sequence-specific DNA-binding Function of p53 by Protein Kinases T.R. Hupp and D.P. Lane 195
DNA-binding Properties of the p53 Tumor Suppressor Protein C. Prives, J. Bargonetti, G. Farmer, E. Ferrari, P. Friedlander, L. Jayaraman, N. Pav letich, Y. Wang, and U. Hubscher 207
Functions of the p53 Protein in Growth Regulation and Tumor Suppression J. Lin, X. Wu, J. Chen, A. Chang, and A.J. Levine 215
Targets for Transcriptional Activation by Wild-type p53: Endogenous Retroviral LTR, Immunoglobulin Heavy-chain Promoter, and an Internal Promoter of the mdm-2 Gene Y. Barak, A. Lupo, A. Zauberman, T. Juven, R. Aloni-Grunstein, E. Gottlieb, V. Rotter, and M. Oren 225
E6-AP Directs the HPV E6-dependent Inactivation of p53 and Is Representative of a Family of Structurally and Functionally Related Proteins J.M. Huibregtse, M. Scheffner, and P.M. Howley 237
p53-Dependent Apoptosis In Vivo: Impact of p53 Inactivation on Tumorigenesis H. Symonds, L. Krall, L. Remington, M. Sáenz-Robles, T. Jacks, and T. Van Dyke 247
Checkpoints and Genome Stability
Cell Cycle Checkpoints, Gemomic Integrity, and Cancer L. Hartwell, T. Weinert, L. Kadyk, and B. Garvik 259
Genomic Integrity and the Genetics of Cancer T.D. Tlsty, A. White, E. Livanos, M. Sage, H. Roelofs, A. Briot, and B. Poulose 265
DNA Damage Responses: p53 Induction, Cell Cycle Perturbations, and Apoptosis C.E. Canman, C.-Y. Chen, M.-H. Lee, and M.B. Kastan 277
Lymphocyte-specific Genetic Instability and Cancer I.R. Kirsch, J.M. Abdallah, V.L. Bertness, M. Hale, S. Lipkowitz, F. Lista, and D.P. Lombardi 287
Cell Cycle Checkpoint Control Is Bypassed by Human Papillomavirus Oncogenes D.A. Galloway, G.W. Demers, S.A. Foster, C.L. Halbert, and K. Russell 297
Telomerase, Cell Immortality, and Cancer C.B. Harley, N.W. Kim, K.R. Prowse, S.L. Weinrich, K.S. Hirsch, M.D. West, S. Bacchetti, H.W. Hirte, C.M. Counter, C.W. Greider, M.A. Piatyszek, W.E. Wright, and J.W. Shay 307
Three Unusual Repair Deficiencies Associated with Transcription Factor BTF2(TFIIH): Evidence for the Evidence for the Existance of a Transcription Syndrome W. Vermeulen, A.J. van Vuuren, M. Chipoulet, L. Schaeffer, E. Appeldoorn, G. Weeda, N.G.J. Jaspers, A. Priestly, C.F. Arlett, A.R. Lehmann, M. Stefanini, M. Mezzina, A. Sarasin, D. Bootsma, J.-M. Egly, and J.H.J. Hoeijmakers 317
Human Mismatch Repair Genes and Their Association with Hereditary Non-polyposis Colon Cancer R.D. Kolodner, N.R. Hall, J. Lipford, M.F. Kane, M.R.S. Rao, P. Morrison, L. Wirth, P.J. Finan, J. Burn, P. Chapman, C. Earabino, E. Merchant, D.T. Bishop, J. Garber, C.E. Bronner, S.M. Baker, G. Warren, L.G. Smith, A. Linddblom, P. Tannergard, R.J. Bollag, A.R. Godwin, D.C. Ward, M. Nordenskjold, R.M. Liskay, N. Copeland, N. Jenkins, M.K. Lescoe, A. Ewel, S. Lee, J. Griffith, and R. Fishel 331
Defects in Replication Fidelity of Simple Repeated Sequences Reveal a New Mutator Mechanism for Oncogenesis M. Perucho, M.A. Peinado, Y. Ionov, S. Casares, S. Malkhosyan, D. Shibata, and E. Stanbridge 339
Ovarian Tumors Display Persistent Microsatellite Instability Caused by Mutation in the Mismatch Repair Gene hMSH-2 K. Orth, J. Hung, A. Gazdar, M. Mathis, A. Bowcock, and J. Sambrook 349
Loss of Imprinting in Human Cancer A.P. Feinberg, L.M. Kalikin, L.A. Johnson, and J.S. Thompson 357
Enhanced Cell Survival and Tumorigenesis S. Cory, A. Strasser, T. Jacks, L.M. Corcoran, T. Metz, A.W. Harris, and J.M. Adams 365
Apoptosis
The Genetics of Programmed Cell Death in the Nematode Caenorhabditis elegans H.R. Horvitz, S. Shaham, and M.O. Hengartner 377
Bcl-2 Gene Family and the Regulation of Programmed Cell Death X.-M. Yin, Z.N. Oltvai, D.J. Veis-Novack, G.P. Linette, and S.J. Korsmeyer 387
Control of p53-dependent Apoptosis by E1B, Bcl-2, and Ha-ras Proteins E. White, S.-K. Chiou, L. Rao, P. Sabbatini, and H.-J.L. Lin 395
Apoptosis in Carcinogenesis: The Role of p53 A.H. Wyllie, P.J. Carder, A.R. Clarke, K.J. Cripps, S. Gledhill, M.F. Greaves, S. Griffiths, D.J. Harrison, M.L. Hooper, R.G. Morris, C.A. Purdie, and C.C. Bird 403
Cellular Senescence and Cancer J.C. Barrett, L.A. Annab, D. Alcorta, G. Preston, P. Vojta, and Y. Yin 411
Apoptosis and the Prognostic Significance of p53 Mutation S.W. Lowe, S. Bodis, N. Bardeesy, A. McClatchey, L. Remington, H.E. Ruley, D.E. Fisher, T. Jacks, J. Pelletier, and D.E. Housman 419
Genetic Models
Transgenic Approaches to the Analysis of ras and p53 Function in Multistage Carcinogenesis C.J. Kemp, P.A. Burns, K. Brown, H. Nagase, and A. Balmain 427
Mouse Model Systems to Study Multistep Tumorigenesis A. Berns, N. van der Lugt, M. Alkema, M. van Lohuizen, J. Domen, D. Acton, J. Allen, P.W. Laird, and J. Jonkers 435
Tumorigenic and Developmental Effects of Combined Germ-line Mutations in Rb and p53 B.O. Williams, S.D. Morgenbesser, R.A. DePinho, and T. Jacks 449
Insulin-like Growth Factor II Is Focally Up-regulated and Functionally Involved as a Second Signal for Oncogene-induced Tumorigenesis P. Naik, G. Christofori, and D. Hanahan 459
Angiostatin: A Circulating Endothelial Cell Inhibitor That Suppresses Angiogenesis and Tumor Growth M.S. O'Reilly, L. Holmgren, Y. Shing, C. Chen, R.A. Rosenthal, Y. Cao, M. Moses, W.S. Lane, E.H. Sage, and J. Folkman 471
The p53 Tumor Suppressor Gene Inhibits Angiogenesis by Stimulating the Production of Thrombospondin K.M. Dameron, O.V. Volpert, M.A. Tainsky, and N. Bouck 483
Defining the Steps in a Multistep Mouse Model for Mammary Carcinogenesis H.E. Varmus, L.A. Godley, S. Roy, I.C.A. Taylor, L. Yuschenkoff, Y.-P. Shi, D. Pinkel, J. Gray, R. Pyle, M. Aldaz, A. Bradley, D. Medina, and L.A. Donehower 491
The Adenomatous Polyposis Coli Gene of the Mouse in Development and Neoplasia W.F. Dove, C. Luongo, C.S. Connelly, K.A. Gould, A.R. Shoemaker, A.R. Moser, and R.L. Gardner 501
Genetic Instability and Apoptotic Death during Neoplastic Progression of v-myc initiated B-cell Lymphomas in the Bursa of Fabricius P.E. Neiman, J. Summers, S.J. Thomas, S. Xuereb, and G. Loring 509
Colorectal Cancer and the Intersection between Basic and Clinical Research B. Vogelstein and K.W. Kinzler 517
Human Cancer Genes and Their Products
Green Pigs, Red Herrings, and a Golden Hoe: A Retrospective on the Identification of BRCA1 and the Beginning of Its Characterization E.A. Ostermeyer, L.S. Friedman, E.D. Lynch, C.I. Szabo, P. Dowd, M.K. Lee, S.E. Roweell, and M.-C. King 523
Progress toward Isolation of a Breast Cancer Susceptibility Gene, BRCA1 B.L. Weber, K.J. Abel, F.J. Couch, S.D. Merajver, S.C. Chandrasekharappa, L. Castilla,
D. McKinley, P.P. Ho, K. Calzone, T.S. Frank, J. Xu, L.C. Brody, and F.S. Collins 531 RNA Genetics of Breast Cancer: Maspin as Paradigm R. Sager, S. Sheng, A. Anisowicz, G. Sotiropoulou, Z. Zou, G. Stenman, K. Swisshelm, Z. Chen, M.J.C. Hendrix, P. Pemberton, K. Rafidi, and K. Ryan 537
Acute Myeloid Leukemia with INV(16) Produces a Chimeric Transcription Factor with a Myosin Heavy-chain Tail P. Liu, N. Seidel, D. Bodine, N. Speck, S. Tarlé, and F.S. Collins 547
Genetic Alterations in the Chromosome 22q12 Region Associated with Development of Neuroectodermal Tumors G. Thomas, O. Delattre, J. Zucman, P. Merel, C. Desmaze, T. Melot, M. Sanson, K. Hoang-Xuan, B. Plougastel, P. Dejong, G. Rouleau, and A. Aurias 555
Molecular Genetic Changes Found in Human Lung Cancer and Its Precursor Lesions A.F. Gazdar, S. Bader, J. Hung, Y. Kishimoto, Y. Sekido, K. Sugio, A. Virmani, D.P. Carbone, and J.D. Minna 565
Molecular Characterization of QM, a Novel Gene with Properties Consistent with Tumor Suppressor Function E. Stanbridge, A. Farmer, A. Mills, T. Loftus, D. Kongkasuriyachai, S. Dowdy, and B. Weissman 573
Barrett's Esophagus: A Model of Human Neoplastic Progression K. Neshat, C.A. Sanchez, P.C. Galipeau, D.S. Cowan, S. Ramel, D. S. Levine, and B.J. Reid 577
Detection of Genetic Loss in Tumors by Representational Difference Analysis N.A. Lisitsyn, F.S. Leach, B. Vogelstein, and M.H. Wigler 585
Genetic Approaches to Defining Signaling by the CML-Associated Tyrosine Kinase BCR-ABL D.E.H. Afar, A. Goga, L. Cohen, C.L. Sawyers, J. McLaughlin, R.N. Mohr, and O.N. Witte 589
The AML1 Gene in the 8;21 and 3;21 Translocations in Chronic and Acute Myeloid Leukemia G. Nucifora and J.D. Rowley 595
Expression of P-Glycoprotein in Normal and Malignant Rat Liver Cells C.H. Lee, G. Bradley, and V. Ling 607
Genes Coding for Tumor-specific Rejection Antigens T. Boon, B. Van den Eynde, H. Hirsch, C. Moroni, E. De Plaen, P. van der Bruggen, C. De Smet, C. Lurquin, J.-P. Szikora, and O. De Backer 617
Pathogenesis of Cancer of the Cervix H. zur Hausen and F. Rösl 623
Autocrine Mechanism for met Proto-oncogene Tumorigenicity S. Rong and G.F. Vande Woude 629
Studies of the Deleted in Colorectal Cancer Gene in Normal and Neoplastic Tissues E.R. Fearon, B.C. Ekstrand, G. Hu, W.E. Pierceall, M.A. Reale, and S.H. Bigner 637
Molecular Cytogenetics of Human Breast Cancer J.W. Gray, C. Collins,I.C. Henderson, J. Isola, A. Kallioniemi, O.-P. Kallioniemi H. Nakamura, D. Pinkel, T. Stokke, M. Tanner, and F. Waldman 645
Genetic Alterations in Prostate Cancer W.B. Isaacs, G.S. Bova, R.A. Morton, M.J.G. Bussemakers, J.D. Brooks, and C.M. Ewing 653
Multicellular Resistance: A New Paradigm to Explain Aspects of Acquired Drug Resistance of Solid Tumors R.S. Kerbel, J. Rak, H. Kobayashi, B. St. Croix, and C.H. Graham 661
Genetic Methods for Diagnosis and Cancer Therapy
Overcoming Complexities in Genetic Screening for Cancer Susceptibility S.H. Friend, R. Iggo, C. Ishioka, M. Fitzgerald, I. Hoover, E. O'Neill, and T. Frebourg 673
Exploiting Multidrug Resistance to Treat Cancer M.M. Gottesman, S.V. Ambudkar, B. Ni, J.M. Sran, Y. Sugimoto, C.O. Cardarelli, and I. Pastan 677
Toxicity and Immunologic Effects of In Vivo Retroviral-Mediated Gene Transfer of the Herpes Simplex-Thymidine Kinase Gene into Solid Tumors K.W. Culver, D.W. Moorman, R.R. Muldoon, R.M. Paulsen, Jr., J.L. Lamsam, H.W. Walling, and C.J. Link, Jr. 685
Gene Marrow and Bone Marrow Transplantation M.K. Brenner, H.E. Heslop, D. Rill, C. Li, T. Nilson, M. Roberts, C. Smith, R. Krance, and C. Rooney 691
Molecular Genetic Interventions for Cancer G.J. Nabel, E.G. Nabel, Z. Yang, B.A. Fox, G.E. Plautz, X. Gao, L. Huang, S. Shu, D. Gordon, and A.E. Chang 699
An Introduction to the Puzzle E. Harlow 709
The Cancer Cell and the Cell Cycle Clock M. Hatakeyama, R.A. Herrera, T. Makela, S.F. Dowdy, T. Jacks, and R.A. Weinberg 1
D-type Cyclins and Their Cyclin-dependent Kinases: G1 Phase Integrators of the Mitogenic Response C.J. Sherr, J. Kato, D.E. Quelle, M. Matsuoka, and M.F. Roussel 11
p21 Is a Component of Active Cell Cycle Kinases H. Zhang, G.J. Hannon, D. Casso, and D. Beach 21
Cyclins, Cdks,, and Cyclin Kinase Inhibitor J.M. Roberts, A. Koff, K. Polyak, E. Firpo, S. Collins, M. Ohtsubo, and J. Massagué 31
Role of a Cell Cycle Regulator in Hereditary and Sporadic Cancer A. Kamb 39
p16INK4 Mutations and Altered Expression in Human Tumors and Cell Lines A. Okamoto, D.J. Demetrick, E.A. Spillare, K. Hagiwara, S.P. Hussain, W.P. Bennett, K. Forrester, B. Gerwin, M.S. Greenblatt, M. Serrano, M. Shiseki, J. Yokota, D.H. Beach, and C.C. Harris 49
Molecular Genetic Approaches to the Study of Cellular Senescence T.J. Goletz, J.R. Smith, and O.M. Pereira-Smith 59
Molecular and Cell Biology of Replicative Senescence G.P. Dimri and J. Campisi 67
Growth Suppression by Members of the Retinoblastoma Protein Family L. Zhu, G.H. Enders, C.-L. Wu, M.A. Starz, K.H. Moberg, J.A. Lees, N. Dyson, and E. Harlow 75
The Adenovirus E1A-associated 300-kD Protein Exhibits Properties of a Transcriptional Coactivator and Belongs to an Evolutionarily Conserved Family R. Eckner, Z. Arany, M. Ewen, W. Sellers, and D.M. Livingston 85
The Corral Hypothesis: A Novel Regulatory Mode for Retinoblastoma Protein Function W.-H. Lee, Y. Xu, F. Hong, T. Durfee, M.A. Mancini, Y. Ueng, P.-L. Chen, and D. Riley 97
The Max Transcription Factor Network: Involvement of Mad in Differentiation and an Approach to Identification of Target Genes P. Hurlin, D.E. Ayer, C. Grandori, and R.N. Eisenman 109
BCL-6 and the Molecular Pathogenesis of B-cell Lymphoma R. Dalla-Favera, B.H. Ye, F. Lo Coco, C.C. Chang, K. Cechova, J. Zhang, A. Migliazza, W. Mellado, H. Niu, S. CHaganti, K. Offit, W. Chen, P.H. Rao, N.Z. Parsa, D.C. Louie, and R.S.K. Chaganti 117
Functional Analysis of the TAN-1 Gene, a Human Homolog of Drosophila Notch J. Aster, W. Pear, R. Hasserjian, H. Erba, F. Davi, B. Luo, M. Scott, D. Baltimore, and J. Sklar 125
Novel Oncogenic Mutations in the WT1 Wilms' Tumor Suppressor Gene: A t(11;22) Fuses the Ewing's Sarcoma Gene, EWS1 to WT1 in Desmoplastic Small Round Cell Tumor F.J. Rauscher III, L.E. Benjamin, W.J. Fredericks, and J.F. Morris 137
Ras Signal Transduction Pathway in Drosophila Eye Development H.C. Chang, F.D. Karim, E.M. O'Neill, I. Rebay, N.M. Solomon, M. Therrien, D.A. Wassarman, T. Wolff, and G.M. Rubin 147
Molecular Genetics of Protooncogenes and Candidate Tumor Suppressors in Caenorhabditis elegans P.W. Sternberg, C.H. Yoon, J. Lee, G.D. Jongeward, P.S. Kayne, W.S. Katz, G. Lesa, J. Liu, A. Golden, L.S. Huang, and H.M. Chamberlin 155
Proto-oncogenes and Plasticity in Cell Signaling J.M. Bishop, A.J. Capobianco, H.J. Doyle, R.E. Finney, M. McMahon, S.M. Robbins, M.L. Samuels, and M. Vetter 165
Activation of Ras and Other Signaling Pathways by Receptor Tyrosine Kinases J. Schlessinger and D. Bar-Sagi 173
Ras Partners L. Van Aelst, M. White, and M.H. Wigler 181
Proteins of the 14-3-3 Family Associate with Raf and Contribute to Its Activation E. Freed, F. McCormick, and R. Ruggieri 187
Regulation of the Cryptic Sequence-specific DNA-binding Function of p53 by Protein Kinases T.R. Hupp and D.P. Lane 195
DNA-binding Properties of the p53 Tumor Suppressor Protein C. Prives, J. Bargonetti, G. Farmer, E. Ferrari, P. Friedlander, L. Jayaraman, N. Pav letich, Y. Wang, and U. Hubscher 207
Functions of the p53 Protein in Growth Regulation and Tumor Suppression J. Lin, X. Wu, J. Chen, A. Chang, and A.J. Levine 215
Targets for Transcriptional Activation by Wild-type p53: Endogenous Retroviral LTR, Immunoglobulin Heavy-chain Promoter, and an Internal Promoter of the mdm-2 Gene Y. Barak, A. Lupo, A. Zauberman, T. Juven, R. Aloni-Grunstein, E. Gottlieb, V. Rotter, and M. Oren 225
E6-AP Directs the HPV E6-dependent Inactivation of p53 and Is Representative of a Family of Structurally and Functionally Related Proteins J.M. Huibregtse, M. Scheffner, and P.M. Howley 237
p53-Dependent Apoptosis In Vivo: Impact of p53 Inactivation on Tumorigenesis H. Symonds, L. Krall, L. Remington, M. Sáenz-Robles, T. Jacks, and T. Van Dyke 247
Checkpoints and Genome Stability
Cell Cycle Checkpoints, Gemomic Integrity, and Cancer L. Hartwell, T. Weinert, L. Kadyk, and B. Garvik 259
Genomic Integrity and the Genetics of Cancer T.D. Tlsty, A. White, E. Livanos, M. Sage, H. Roelofs, A. Briot, and B. Poulose 265
DNA Damage Responses: p53 Induction, Cell Cycle Perturbations, and Apoptosis C.E. Canman, C.-Y. Chen, M.-H. Lee, and M.B. Kastan 277
Lymphocyte-specific Genetic Instability and Cancer I.R. Kirsch, J.M. Abdallah, V.L. Bertness, M. Hale, S. Lipkowitz, F. Lista, and D.P. Lombardi 287
Cell Cycle Checkpoint Control Is Bypassed by Human Papillomavirus Oncogenes D.A. Galloway, G.W. Demers, S.A. Foster, C.L. Halbert, and K. Russell 297
Telomerase, Cell Immortality, and Cancer C.B. Harley, N.W. Kim, K.R. Prowse, S.L. Weinrich, K.S. Hirsch, M.D. West, S. Bacchetti, H.W. Hirte, C.M. Counter, C.W. Greider, M.A. Piatyszek, W.E. Wright, and J.W. Shay 307
Three Unusual Repair Deficiencies Associated with Transcription Factor BTF2(TFIIH): Evidence for the Evidence for the Existance of a Transcription Syndrome W. Vermeulen, A.J. van Vuuren, M. Chipoulet, L. Schaeffer, E. Appeldoorn, G. Weeda, N.G.J. Jaspers, A. Priestly, C.F. Arlett, A.R. Lehmann, M. Stefanini, M. Mezzina, A. Sarasin, D. Bootsma, J.-M. Egly, and J.H.J. Hoeijmakers 317
Human Mismatch Repair Genes and Their Association with Hereditary Non-polyposis Colon Cancer R.D. Kolodner, N.R. Hall, J. Lipford, M.F. Kane, M.R.S. Rao, P. Morrison, L. Wirth, P.J. Finan, J. Burn, P. Chapman, C. Earabino, E. Merchant, D.T. Bishop, J. Garber, C.E. Bronner, S.M. Baker, G. Warren, L.G. Smith, A. Linddblom, P. Tannergard, R.J. Bollag, A.R. Godwin, D.C. Ward, M. Nordenskjold, R.M. Liskay, N. Copeland, N. Jenkins, M.K. Lescoe, A. Ewel, S. Lee, J. Griffith, and R. Fishel 331
Defects in Replication Fidelity of Simple Repeated Sequences Reveal a New Mutator Mechanism for Oncogenesis M. Perucho, M.A. Peinado, Y. Ionov, S. Casares, S. Malkhosyan, D. Shibata, and E. Stanbridge 339
Ovarian Tumors Display Persistent Microsatellite Instability Caused by Mutation in the Mismatch Repair Gene hMSH-2 K. Orth, J. Hung, A. Gazdar, M. Mathis, A. Bowcock, and J. Sambrook 349
Loss of Imprinting in Human Cancer A.P. Feinberg, L.M. Kalikin, L.A. Johnson, and J.S. Thompson 357
Enhanced Cell Survival and Tumorigenesis S. Cory, A. Strasser, T. Jacks, L.M. Corcoran, T. Metz, A.W. Harris, and J.M. Adams 365
Apoptosis
The Genetics of Programmed Cell Death in the Nematode Caenorhabditis elegans H.R. Horvitz, S. Shaham, and M.O. Hengartner 377
Bcl-2 Gene Family and the Regulation of Programmed Cell Death X.-M. Yin, Z.N. Oltvai, D.J. Veis-Novack, G.P. Linette, and S.J. Korsmeyer 387
Control of p53-dependent Apoptosis by E1B, Bcl-2, and Ha-ras Proteins E. White, S.-K. Chiou, L. Rao, P. Sabbatini, and H.-J.L. Lin 395
Apoptosis in Carcinogenesis: The Role of p53 A.H. Wyllie, P.J. Carder, A.R. Clarke, K.J. Cripps, S. Gledhill, M.F. Greaves, S. Griffiths, D.J. Harrison, M.L. Hooper, R.G. Morris, C.A. Purdie, and C.C. Bird 403
Cellular Senescence and Cancer J.C. Barrett, L.A. Annab, D. Alcorta, G. Preston, P. Vojta, and Y. Yin 411
Apoptosis and the Prognostic Significance of p53 Mutation S.W. Lowe, S. Bodis, N. Bardeesy, A. McClatchey, L. Remington, H.E. Ruley, D.E. Fisher, T. Jacks, J. Pelletier, and D.E. Housman 419
Genetic Models
Transgenic Approaches to the Analysis of ras and p53 Function in Multistage Carcinogenesis C.J. Kemp, P.A. Burns, K. Brown, H. Nagase, and A. Balmain 427
Mouse Model Systems to Study Multistep Tumorigenesis A. Berns, N. van der Lugt, M. Alkema, M. van Lohuizen, J. Domen, D. Acton, J. Allen, P.W. Laird, and J. Jonkers 435
Tumorigenic and Developmental Effects of Combined Germ-line Mutations in Rb and p53 B.O. Williams, S.D. Morgenbesser, R.A. DePinho, and T. Jacks 449
Insulin-like Growth Factor II Is Focally Up-regulated and Functionally Involved as a Second Signal for Oncogene-induced Tumorigenesis P. Naik, G. Christofori, and D. Hanahan 459
Angiostatin: A Circulating Endothelial Cell Inhibitor That Suppresses Angiogenesis and Tumor Growth M.S. O'Reilly, L. Holmgren, Y. Shing, C. Chen, R.A. Rosenthal, Y. Cao, M. Moses, W.S. Lane, E.H. Sage, and J. Folkman 471
The p53 Tumor Suppressor Gene Inhibits Angiogenesis by Stimulating the Production of Thrombospondin K.M. Dameron, O.V. Volpert, M.A. Tainsky, and N. Bouck 483
Defining the Steps in a Multistep Mouse Model for Mammary Carcinogenesis H.E. Varmus, L.A. Godley, S. Roy, I.C.A. Taylor, L. Yuschenkoff, Y.-P. Shi, D. Pinkel, J. Gray, R. Pyle, M. Aldaz, A. Bradley, D. Medina, and L.A. Donehower 491
The Adenomatous Polyposis Coli Gene of the Mouse in Development and Neoplasia W.F. Dove, C. Luongo, C.S. Connelly, K.A. Gould, A.R. Shoemaker, A.R. Moser, and R.L. Gardner 501
Genetic Instability and Apoptotic Death during Neoplastic Progression of v-myc initiated B-cell Lymphomas in the Bursa of Fabricius P.E. Neiman, J. Summers, S.J. Thomas, S. Xuereb, and G. Loring 509
Colorectal Cancer and the Intersection between Basic and Clinical Research B. Vogelstein and K.W. Kinzler 517
Human Cancer Genes and Their Products
Green Pigs, Red Herrings, and a Golden Hoe: A Retrospective on the Identification of BRCA1 and the Beginning of Its Characterization E.A. Ostermeyer, L.S. Friedman, E.D. Lynch, C.I. Szabo, P. Dowd, M.K. Lee, S.E. Roweell, and M.-C. King 523
Progress toward Isolation of a Breast Cancer Susceptibility Gene, BRCA1 B.L. Weber, K.J. Abel, F.J. Couch, S.D. Merajver, S.C. Chandrasekharappa, L. Castilla,
D. McKinley, P.P. Ho, K. Calzone, T.S. Frank, J. Xu, L.C. Brody, and F.S. Collins 531 RNA Genetics of Breast Cancer: Maspin as Paradigm R. Sager, S. Sheng, A. Anisowicz, G. Sotiropoulou, Z. Zou, G. Stenman, K. Swisshelm, Z. Chen, M.J.C. Hendrix, P. Pemberton, K. Rafidi, and K. Ryan 537
Acute Myeloid Leukemia with INV(16) Produces a Chimeric Transcription Factor with a Myosin Heavy-chain Tail P. Liu, N. Seidel, D. Bodine, N. Speck, S. Tarlé, and F.S. Collins 547
Genetic Alterations in the Chromosome 22q12 Region Associated with Development of Neuroectodermal Tumors G. Thomas, O. Delattre, J. Zucman, P. Merel, C. Desmaze, T. Melot, M. Sanson, K. Hoang-Xuan, B. Plougastel, P. Dejong, G. Rouleau, and A. Aurias 555
Molecular Genetic Changes Found in Human Lung Cancer and Its Precursor Lesions A.F. Gazdar, S. Bader, J. Hung, Y. Kishimoto, Y. Sekido, K. Sugio, A. Virmani, D.P. Carbone, and J.D. Minna 565
Molecular Characterization of QM, a Novel Gene with Properties Consistent with Tumor Suppressor Function E. Stanbridge, A. Farmer, A. Mills, T. Loftus, D. Kongkasuriyachai, S. Dowdy, and B. Weissman 573
Barrett's Esophagus: A Model of Human Neoplastic Progression K. Neshat, C.A. Sanchez, P.C. Galipeau, D.S. Cowan, S. Ramel, D. S. Levine, and B.J. Reid 577
Detection of Genetic Loss in Tumors by Representational Difference Analysis N.A. Lisitsyn, F.S. Leach, B. Vogelstein, and M.H. Wigler 585
Genetic Approaches to Defining Signaling by the CML-Associated Tyrosine Kinase BCR-ABL D.E.H. Afar, A. Goga, L. Cohen, C.L. Sawyers, J. McLaughlin, R.N. Mohr, and O.N. Witte 589
The AML1 Gene in the 8;21 and 3;21 Translocations in Chronic and Acute Myeloid Leukemia G. Nucifora and J.D. Rowley 595
Expression of P-Glycoprotein in Normal and Malignant Rat Liver Cells C.H. Lee, G. Bradley, and V. Ling 607
Genes Coding for Tumor-specific Rejection Antigens T. Boon, B. Van den Eynde, H. Hirsch, C. Moroni, E. De Plaen, P. van der Bruggen, C. De Smet, C. Lurquin, J.-P. Szikora, and O. De Backer 617
Pathogenesis of Cancer of the Cervix H. zur Hausen and F. Rösl 623
Autocrine Mechanism for met Proto-oncogene Tumorigenicity S. Rong and G.F. Vande Woude 629
Studies of the Deleted in Colorectal Cancer Gene in Normal and Neoplastic Tissues E.R. Fearon, B.C. Ekstrand, G. Hu, W.E. Pierceall, M.A. Reale, and S.H. Bigner 637
Molecular Cytogenetics of Human Breast Cancer J.W. Gray, C. Collins,I.C. Henderson, J. Isola, A. Kallioniemi, O.-P. Kallioniemi H. Nakamura, D. Pinkel, T. Stokke, M. Tanner, and F. Waldman 645
Genetic Alterations in Prostate Cancer W.B. Isaacs, G.S. Bova, R.A. Morton, M.J.G. Bussemakers, J.D. Brooks, and C.M. Ewing 653
Multicellular Resistance: A New Paradigm to Explain Aspects of Acquired Drug Resistance of Solid Tumors R.S. Kerbel, J. Rak, H. Kobayashi, B. St. Croix, and C.H. Graham 661
Genetic Methods for Diagnosis and Cancer Therapy
Overcoming Complexities in Genetic Screening for Cancer Susceptibility S.H. Friend, R. Iggo, C. Ishioka, M. Fitzgerald, I. Hoover, E. O'Neill, and T. Frebourg 673
Exploiting Multidrug Resistance to Treat Cancer M.M. Gottesman, S.V. Ambudkar, B. Ni, J.M. Sran, Y. Sugimoto, C.O. Cardarelli, and I. Pastan 677
Toxicity and Immunologic Effects of In Vivo Retroviral-Mediated Gene Transfer of the Herpes Simplex-Thymidine Kinase Gene into Solid Tumors K.W. Culver, D.W. Moorman, R.R. Muldoon, R.M. Paulsen, Jr., J.L. Lamsam, H.W. Walling, and C.J. Link, Jr. 685
Gene Marrow and Bone Marrow Transplantation M.K. Brenner, H.E. Heslop, D. Rill, C. Li, T. Nilson, M. Roberts, C. Smith, R. Krance, and C. Rooney 691
Molecular Genetic Interventions for Cancer G.J. Nabel, E.G. Nabel, Z. Yang, B.A. Fox, G.E. Plautz, X. Gao, L. Huang, S. Shu, D. Gordon, and A.E. Chang 699
An Introduction to the Puzzle E. Harlow 709
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