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 LVII: The Cell Surface 1992 |
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Poster Session, 1992  SYMPOSIUM SYNOPSIS LIST OF PARTICIPANTS CONTENTS OF SYMPOSIUM VOLUME PHOTOGRAPHS PUBLISHED VOLUME  |
The Cell Surface
Symposium Volume LVII Contents
Symposium Participants v
Foreword xvii
Receptors
Receptors and Transmembrane Signaling B.L. Stoddard, H.-P. Biemann, and D.E. Koshland, Jr. 1
A Model for Transmembrane Signaling in a Bacterial Chemotaxis Receptor S.-H. Kim, G.G. Privé, J. Yeh, W.G. Scott, and M.V. Milburn 17
Receptor Protein-Tyrosine Kinases and Phosphatases T. Hunter, R.A. Lindberg, D.S. Middlemas, S. Tracy, and P. van der Geer 5
The trk Family Tyrosine Kinases: Receptors for NGF-related Neurotrophins L.F. Parada, P. Tsoulfas, L. Tessarollo, J. Blair, S. Reid, and D. Soppet 43
Cloning and Analysis of Neurotrophic Factor Receptors Using Function-based Strategies D.J. Glass, D.R. Gies, T. Stitt, S. Davis, P. Hantzopoulos, N.Y. Ip, M. Goldfarb, and G.D. Yancopoulos 53
Interactions of PDGF and FGF Receptors with Cytoplasmic Signaling Molecules K.G. Peters, J.A. Escobedo, W.J. Fantl, and L.T. Williams 63
Role of SH2-containing Proteins in Cellular Signaling by Receptor Tyrosine Kinases J. Schlessinger, M. Mohammadi, B. Margolis, and A. Ullrich 67
Phosphatidylinositol-3 Kinase and Growth Regulation S.P. Soltoff, C.L. Carpenter, K.R. Auger, R. Kapeller, B. Schaffhausen, and L.C. Cantley 75
The Type II TGF-b Receptor Signals Diverse Responses in Cooperation with the Type I Receptor J.L. Wrana, J. Carcamo, L. Attisano, S. Cheifetz, A. Zentella, F. López-Casillas, and J. Massagué 81
Protein Tyrosine Phosphatases: The Problems of a Growing Family N.K. Tonks, Q. Yang, A.J. Flint, M.F.B.G. Gebbink, B.R. Franza, Jr., D.E. Hill, H. Sun, and S. Brady-Kalnay 87
The Erythropoietin Receptor: Dimerization, Activation, and Tumorigenesis H.F. Lodish, D. Hilton, G. Longmore, S.S. Watowich, and A. Yoshimura 95
Regulation of Protein Tyrosine Kinase Activation by the T Cell Antigen Receptor z Chain A. Weiss, A.C. Chan, M. Iwashima, D. Straus, and B.A. Irving 107
Activation of Immune System Effector Function by T-cell or Fc Receptor Intracellular Domains C. Romeo, W. Kolanus, M. Amiot, and B. Seed 117
G-Protein Coupled Receptors and Effectors
G-Protein-coupled Receptors: Regulatory Role of Receptor Kinases and Arrestin Proteins R.J. Lefkowitz, J. Inglese, W.J. Koch, J. Ritcher, H. Attramadal, and M.G. Caron 127
Regulation of Mammalian Adenylyl Cyclases by G Protein a and bg Subunits W.-J. Tang, J.A. Iñiguez-Lluhi, S. Mumby, and A.G. Gilman 135
Detection of Coincident Signals by G Proteins and Adenylyl Cyclase H.R. Bourne, K.O. Lustig, Y.H. Wong, and B.R. Conklin 145
Thrombin Receptor Structure and Function S.R. Coughlin, R.M. Scarborough, T.-K.H. Vu, and D.T. Hung 149
Guanylyl Cyclases: Ligands and Functions T.D. Chrisman, S. Schulz, and D.L. Garbers 155
Lysophosphatidic Acid: A Novel Phospholipid with Hormone- and Growth Factor-like Activities W.H. Moolenaar, R.L. van der Bend, E.J. van Corven, K. Jalink, T. Eichholtz, and W.J. van Blitterswijk 163
G-Protein-linked Signaling Pathways Mediate Development in Dictyostelium R.L. Johnson, R. Gundersen, D. Hereld, G.S. Pitt, S. Tugendreich, C.L. Saxe, A.R. Kimmel, and P.N. Devreotes 169
Molecular Genetic Analysis of Signal Transduction Pathways Controlling Multicellular Development in Dictyostelium A.B. Cubitt, F. Carrel, S. Dharmawardhane, C. Gaskins, J. Hadwiger, P. Howard, S.K.O. Mann, K. Okaichi, K. Zhou, and R.A. Firtel 177
Adhesion Receptors
Signaling between the Extracellular Matrix and the Cytoskeleton: Tyrosine Phosphorylation and Focal Adhesion Assembly L.H. Romer, K. Burridge, and C.E. Turner 193
Mechanisms of Fibronectin and Integrin Function during Cell Adhesion and Migration K.M. Yamada, S. Aota, S.K. Akiyama, and S.E. LaFlamme 203
Functional Roles for Integrin a-Subunit Cytoplasmic Domains M.E. Hemler, P.D. Kassner, and B.M.C. Chan 213
Ligand Binding to Integrins: Dynamic Regulation and Common Mechanisms M.H. Ginsberg, T.E. O'Toole, J.C. Loftus, and E.F. Plow 221
Role of aV Integrins and Vitronectin in Human Melanoma Cell Growth L.C. Sanders, B. Felding-Habermann, B.M. Mueller, and D.A. Cheresh 233
Genetic Interactions with Integrins during Wing Morphogenesis in Drosophila L.H.V. Wessendorf, M. Wehrli, A. DiAntonio, and M. Wilcox 241
Toward a Genetic Analysis of Cellular-Matrix Adhesion R.O. Hynes, E.L. George, E.N. Georges, J.-L. Guan, H. Rayburn, and J.T. Yang 249
Glycosylation-dependent Cell Adhesion Molecule 1: A Novel Mucin-like Adhesion Ligand for L-Selectin L.A. Lasky, M.S. Singer, D. Dowbenko, Y.Imai, W. Henzel, C. Fennie, S. Watson, and S.D. Rosen 259
Quantitative Determination of Selectin-Carbohydrate Interactions R.M. Nelson, A. Aruffo, S. Dolich, O. Cecconi, G. Mannori, and M.P. Bevilacqua 271
Molecular Mechanisms of Complex Carbohydrate Recognition at the Cell Surface W.I. Weis, M.S. Quesenberry, M.E. Taylor, K. Bezouška, W.A. Hendrickson, and K. Drickamer 281
Lymphocyte Homing Receptors M.C.-T. Hu, M.H. Siegelman, B. Holzmann, D.T. Crowe, and I.L. Weissman 291
Extracellular Matrix/Growth Factor Interactions E. Ruoslahti, Y. Yamaguchi, A. Hildebrand, and W.R. Border 309
Mediation and Inhibition of Cell Adhesion by Morphoregulatory Molecules G.M. Edelman 317
Cytoplasmic Control of Cadherin-mediated Cell-Cell Adhesions M. Takeichi, S. Hirano, N. Matsuyoshi, and T. Fujimori 327
Cadherins and the Morphogenesis of Epithelial Tissues in Xenopus Embryos C. Kintner 335
DCC: A Tumor Suppressor Gene Expressed on the Cell Surface L. Hedrick, K.R. Cho, J. Boyd, J. Risinger, and B. Vogelstein 345
Development
Intercellular Signaling during Caenorhabditis elegans Vulval Induction P.W. Sternberg, R.J. Hill, G. Jongeward, L.S. Huang, and L. Carta 353
Genes Involved in Two Caenorhabditis elegans Cell-signaling Pathways S.G. Clark, M.J. Stern, and H.R. Horvitz 363
Signal Transduction Pathway Initiated by Activation of the sevenless Tyrosine Kinase Receptor M.A. Simon, R.W. Carthew, M.E. Fortini, U. Gaul, G. Mardon, and G.M. Rubin 375
Induction of the R7 Neuron in the Drosophila Compound Eye: The bride of sevenless and sevenless Interaction S.L. Zipursky, H. Krämer, R. Cagan, A. Hart, and D. Van Vactor, Jr. 381
Delta, Notch, and shaggy, Elements of a Lateral Signaling Pathway in Drosophila P. Simpson, M. Bourouis, P. Heitzler, L. Ruel, M. Haenlin, and P. Ramain 391
Regulation of Induction by GLP1, a Localized Cell Surface Receptor in Caenorhabditis elegans J. Kimble, S. Crittenden, E. Lambie, V. Kodoyianni, S. Mango, and E. Troemel 401
Extracellular Morphogens in Drosophila Embryonic Dorsal-Ventral Patterning K.V. Anderson, D.S. Schneider, D. Morisato, and E.L. Ferguson 409
Neurobiology
Adhesive Interactions That Regulate Development of the Retina and Primary Visual Projection L.F. Reichardt, B. Bossy, I. de Curtis, K.M. Neugebauer, K. Venstrom, and D. Sretavan 419
Second Messengers Underlying Cell-conact-dependent Axonal Growth Stimulated by Transfected N-CAM, N-cadherin, or L1 F.S. Walsh and P. Doherty 431
Development of Neuromuscular Specificity in Drosophila A. Nose, D. Van Vactor, V. Auld, and C.S. Goodman 441
Rostrocaudal Differences among Muscles Revealed by a Transgene: Graded Expression at Low Copy Number J.R. Sanes, M.J. Donoghue, M.C. Wallace, and J.P. Merlie 451
Agrin: A Synaptic Basal Lamina Protein That Regulates Development of the Neuromuscular Junction J.T. Campanelli, M. Ferns, W. Hoch, F. Rupp, M. von Zastrow, Z. Hall, and R. H. Scheller 461
Control of Floor Plate Identity and Function in the Embryonic Nervous System A. Klar, T.M. Jessell, and A. Ruiz i Altaba 473
Neurexins M. Geppert, Y.A. Ushkaryov, Y. Hata, B. Davletov, A.G. Petrenko, and T.C. Südhof 483
Elucidation of Biophysical and Biological Properties of Voltage-gated Potassium Channels T.J. Baldwin, E. Isacoff, M. Li, G.A. Lopez, M. Sheng, M.L. Tsaur, Y.N. Jan, and L.Y. Jan 491
Mechanisms of Sensitivity and Specificity in Olfaction R.R. Reed 501
The Molecular Biology of Smell: Expression of the Multigene Family Encoding Putative Odorant Receptors A. Chess, L. Buck, M.M. Dowling, R. Axel, and J. Ngai 505
Pharmacological and Genetic Approaches to the Analysis of Tyrosine Kinase Function in Long-term Potentiation T.J. O'Dell, S.G.N. Grant, K. Klar, P.M. Soriano, and E.R. Kandel 517
a Calcium/Calmodulin Kinase II Mutant Mice: Deficient Long-term Potentiation and Impaired Spatial Learning A.J. Silva, Y. Wang, R. Paylor, J.M. Wehner, C.F. Stevens, and S. Tonegawa 527
Structure and Interactions of CD4 S.C. Harrison, J. Wang, Y. Yan, T. Garrett, J. Liu, U. Moebius, and E. Reinherz 541
Structural Aspects of CD4 and CD8 Involvement in the Cellular Immune Response W.A. Hendrickson, P.D. Kwong, D.J. Leahy, S.-E. Ryu, H. Yamaguchi, S. Fleury, and R.-P. Sékaly 549
Biochemical Anatomy of Antigen Processing C.A. Nelson, C.V. Harding, and E.R. Unanue 557
MHC Products: Biosybthesis, Intracellular Traffic, and "Empty" Molecules H.L. Ploegh 565
Transport and Expression of Class I MHC Glycoproteins in an Antigen-processing Mutant Cell Line E.-M. Click, K.S. Anderson, M.J. Androlewicz, M.L. Wei, and P. Cresswell 571
Dedicated Transporters for Peptide Export and Intercompartmental Traffic in the Yeast Saccharpmyces cerevisiae K. Kuchler, H.M. Göransson, M.N. Viswanathan, and J. Thorner 579
Membrane Traffic and Cytoskeletal Assembly
Each Caveola Contains Multiple Glycosyl-Phosphatidylinositol Anchored Membrane Proteins Y.-S. Ying, R.G.W. Anderson, and K.G. Rothberg 593
Molecular Flypaper, Atherosclerosis, and Host Defense: Structure and Function of the Macrophage Scavenger Receptor M. Krieger, J.M. Abrams, A. Lux, and H. Steller 605
Biogenesis of Cell-Surface Polarity in Epithelial Cells and Neurons K. Simons, P. Dupree, K. Fiedler, L. Huber, T. Kobayashi, T. Kurzchalia, V. Olkkonen, S. Pimplikar, R. Parton, and C. Dotti 611
Regulation of Epithelial Cell Polarity: A View from the Cell Surface W.J. Nelson, R. Wilson, D. Wollner, R. Mays, H. McNeill, and K. Siemers 621
Cytoplasmic Control of Cell Adhesion B. Geiger, O. Ayalon, D. Ginsberg, T. Volberg, J.L. Rodríguez Fernández Y. Yarden, and A. Ben-Ze'ev 631
Desmosomal Proteins: Mediators of Intercellular Coupling and Intermediate Filament Anchorage W.W. Franke, S.M. Troyanovsky, P.J. Koch, R. Troyanovsky, B. Fouquet, and R. E. Leube 643
Role of the Zygotic Genome in the Restructuring of the Actin Cytoskeleton at the Cycle-14 Transition during Drosophila Embryogenesis E.D. Schejter, L.S. Rose, M.A. Postner, and E. Wieschaus 653
Distinct Patterns of Actin Organization Regulated by the Small GTP-binding Proteins Rac and Rho A.J. Ridley and A. Hall 661
Summary: The Cell Surface Regulates Information Flow, Material Transport, and Cell Identity M.I. Simon 673
Foreword xvii
Receptors
Receptors and Transmembrane Signaling B.L. Stoddard, H.-P. Biemann, and D.E. Koshland, Jr. 1
A Model for Transmembrane Signaling in a Bacterial Chemotaxis Receptor S.-H. Kim, G.G. Privé, J. Yeh, W.G. Scott, and M.V. Milburn 17
Receptor Protein-Tyrosine Kinases and Phosphatases T. Hunter, R.A. Lindberg, D.S. Middlemas, S. Tracy, and P. van der Geer 5
The trk Family Tyrosine Kinases: Receptors for NGF-related Neurotrophins L.F. Parada, P. Tsoulfas, L. Tessarollo, J. Blair, S. Reid, and D. Soppet 43
Cloning and Analysis of Neurotrophic Factor Receptors Using Function-based Strategies D.J. Glass, D.R. Gies, T. Stitt, S. Davis, P. Hantzopoulos, N.Y. Ip, M. Goldfarb, and G.D. Yancopoulos 53
Interactions of PDGF and FGF Receptors with Cytoplasmic Signaling Molecules K.G. Peters, J.A. Escobedo, W.J. Fantl, and L.T. Williams 63
Role of SH2-containing Proteins in Cellular Signaling by Receptor Tyrosine Kinases J. Schlessinger, M. Mohammadi, B. Margolis, and A. Ullrich 67
Phosphatidylinositol-3 Kinase and Growth Regulation S.P. Soltoff, C.L. Carpenter, K.R. Auger, R. Kapeller, B. Schaffhausen, and L.C. Cantley 75
The Type II TGF-b Receptor Signals Diverse Responses in Cooperation with the Type I Receptor J.L. Wrana, J. Carcamo, L. Attisano, S. Cheifetz, A. Zentella, F. López-Casillas, and J. Massagué 81
Protein Tyrosine Phosphatases: The Problems of a Growing Family N.K. Tonks, Q. Yang, A.J. Flint, M.F.B.G. Gebbink, B.R. Franza, Jr., D.E. Hill, H. Sun, and S. Brady-Kalnay 87
The Erythropoietin Receptor: Dimerization, Activation, and Tumorigenesis H.F. Lodish, D. Hilton, G. Longmore, S.S. Watowich, and A. Yoshimura 95
Regulation of Protein Tyrosine Kinase Activation by the T Cell Antigen Receptor z Chain A. Weiss, A.C. Chan, M. Iwashima, D. Straus, and B.A. Irving 107
Activation of Immune System Effector Function by T-cell or Fc Receptor Intracellular Domains C. Romeo, W. Kolanus, M. Amiot, and B. Seed 117
G-Protein Coupled Receptors and Effectors
G-Protein-coupled Receptors: Regulatory Role of Receptor Kinases and Arrestin Proteins R.J. Lefkowitz, J. Inglese, W.J. Koch, J. Ritcher, H. Attramadal, and M.G. Caron 127
Regulation of Mammalian Adenylyl Cyclases by G Protein a and bg Subunits W.-J. Tang, J.A. Iñiguez-Lluhi, S. Mumby, and A.G. Gilman 135
Detection of Coincident Signals by G Proteins and Adenylyl Cyclase H.R. Bourne, K.O. Lustig, Y.H. Wong, and B.R. Conklin 145
Thrombin Receptor Structure and Function S.R. Coughlin, R.M. Scarborough, T.-K.H. Vu, and D.T. Hung 149
Guanylyl Cyclases: Ligands and Functions T.D. Chrisman, S. Schulz, and D.L. Garbers 155
Lysophosphatidic Acid: A Novel Phospholipid with Hormone- and Growth Factor-like Activities W.H. Moolenaar, R.L. van der Bend, E.J. van Corven, K. Jalink, T. Eichholtz, and W.J. van Blitterswijk 163
G-Protein-linked Signaling Pathways Mediate Development in Dictyostelium R.L. Johnson, R. Gundersen, D. Hereld, G.S. Pitt, S. Tugendreich, C.L. Saxe, A.R. Kimmel, and P.N. Devreotes 169
Molecular Genetic Analysis of Signal Transduction Pathways Controlling Multicellular Development in Dictyostelium A.B. Cubitt, F. Carrel, S. Dharmawardhane, C. Gaskins, J. Hadwiger, P. Howard, S.K.O. Mann, K. Okaichi, K. Zhou, and R.A. Firtel 177
Adhesion Receptors
Signaling between the Extracellular Matrix and the Cytoskeleton: Tyrosine Phosphorylation and Focal Adhesion Assembly L.H. Romer, K. Burridge, and C.E. Turner 193
Mechanisms of Fibronectin and Integrin Function during Cell Adhesion and Migration K.M. Yamada, S. Aota, S.K. Akiyama, and S.E. LaFlamme 203
Functional Roles for Integrin a-Subunit Cytoplasmic Domains M.E. Hemler, P.D. Kassner, and B.M.C. Chan 213
Ligand Binding to Integrins: Dynamic Regulation and Common Mechanisms M.H. Ginsberg, T.E. O'Toole, J.C. Loftus, and E.F. Plow 221
Role of aV Integrins and Vitronectin in Human Melanoma Cell Growth L.C. Sanders, B. Felding-Habermann, B.M. Mueller, and D.A. Cheresh 233
Genetic Interactions with Integrins during Wing Morphogenesis in Drosophila L.H.V. Wessendorf, M. Wehrli, A. DiAntonio, and M. Wilcox 241
Toward a Genetic Analysis of Cellular-Matrix Adhesion R.O. Hynes, E.L. George, E.N. Georges, J.-L. Guan, H. Rayburn, and J.T. Yang 249
Glycosylation-dependent Cell Adhesion Molecule 1: A Novel Mucin-like Adhesion Ligand for L-Selectin L.A. Lasky, M.S. Singer, D. Dowbenko, Y.Imai, W. Henzel, C. Fennie, S. Watson, and S.D. Rosen 259
Quantitative Determination of Selectin-Carbohydrate Interactions R.M. Nelson, A. Aruffo, S. Dolich, O. Cecconi, G. Mannori, and M.P. Bevilacqua 271
Molecular Mechanisms of Complex Carbohydrate Recognition at the Cell Surface W.I. Weis, M.S. Quesenberry, M.E. Taylor, K. Bezouška, W.A. Hendrickson, and K. Drickamer 281
Lymphocyte Homing Receptors M.C.-T. Hu, M.H. Siegelman, B. Holzmann, D.T. Crowe, and I.L. Weissman 291
Extracellular Matrix/Growth Factor Interactions E. Ruoslahti, Y. Yamaguchi, A. Hildebrand, and W.R. Border 309
Mediation and Inhibition of Cell Adhesion by Morphoregulatory Molecules G.M. Edelman 317
Cytoplasmic Control of Cadherin-mediated Cell-Cell Adhesions M. Takeichi, S. Hirano, N. Matsuyoshi, and T. Fujimori 327
Cadherins and the Morphogenesis of Epithelial Tissues in Xenopus Embryos C. Kintner 335
DCC: A Tumor Suppressor Gene Expressed on the Cell Surface L. Hedrick, K.R. Cho, J. Boyd, J. Risinger, and B. Vogelstein 345
Development
Intercellular Signaling during Caenorhabditis elegans Vulval Induction P.W. Sternberg, R.J. Hill, G. Jongeward, L.S. Huang, and L. Carta 353
Genes Involved in Two Caenorhabditis elegans Cell-signaling Pathways S.G. Clark, M.J. Stern, and H.R. Horvitz 363
Signal Transduction Pathway Initiated by Activation of the sevenless Tyrosine Kinase Receptor M.A. Simon, R.W. Carthew, M.E. Fortini, U. Gaul, G. Mardon, and G.M. Rubin 375
Induction of the R7 Neuron in the Drosophila Compound Eye: The bride of sevenless and sevenless Interaction S.L. Zipursky, H. Krämer, R. Cagan, A. Hart, and D. Van Vactor, Jr. 381
Delta, Notch, and shaggy, Elements of a Lateral Signaling Pathway in Drosophila P. Simpson, M. Bourouis, P. Heitzler, L. Ruel, M. Haenlin, and P. Ramain 391
Regulation of Induction by GLP1, a Localized Cell Surface Receptor in Caenorhabditis elegans J. Kimble, S. Crittenden, E. Lambie, V. Kodoyianni, S. Mango, and E. Troemel 401
Extracellular Morphogens in Drosophila Embryonic Dorsal-Ventral Patterning K.V. Anderson, D.S. Schneider, D. Morisato, and E.L. Ferguson 409
Neurobiology
Adhesive Interactions That Regulate Development of the Retina and Primary Visual Projection L.F. Reichardt, B. Bossy, I. de Curtis, K.M. Neugebauer, K. Venstrom, and D. Sretavan 419
Second Messengers Underlying Cell-conact-dependent Axonal Growth Stimulated by Transfected N-CAM, N-cadherin, or L1 F.S. Walsh and P. Doherty 431
Development of Neuromuscular Specificity in Drosophila A. Nose, D. Van Vactor, V. Auld, and C.S. Goodman 441
Rostrocaudal Differences among Muscles Revealed by a Transgene: Graded Expression at Low Copy Number J.R. Sanes, M.J. Donoghue, M.C. Wallace, and J.P. Merlie 451
Agrin: A Synaptic Basal Lamina Protein That Regulates Development of the Neuromuscular Junction J.T. Campanelli, M. Ferns, W. Hoch, F. Rupp, M. von Zastrow, Z. Hall, and R. H. Scheller 461
Control of Floor Plate Identity and Function in the Embryonic Nervous System A. Klar, T.M. Jessell, and A. Ruiz i Altaba 473
Neurexins M. Geppert, Y.A. Ushkaryov, Y. Hata, B. Davletov, A.G. Petrenko, and T.C. Südhof 483
Elucidation of Biophysical and Biological Properties of Voltage-gated Potassium Channels T.J. Baldwin, E. Isacoff, M. Li, G.A. Lopez, M. Sheng, M.L. Tsaur, Y.N. Jan, and L.Y. Jan 491
Mechanisms of Sensitivity and Specificity in Olfaction R.R. Reed 501
The Molecular Biology of Smell: Expression of the Multigene Family Encoding Putative Odorant Receptors A. Chess, L. Buck, M.M. Dowling, R. Axel, and J. Ngai 505
Pharmacological and Genetic Approaches to the Analysis of Tyrosine Kinase Function in Long-term Potentiation T.J. O'Dell, S.G.N. Grant, K. Klar, P.M. Soriano, and E.R. Kandel 517
a Calcium/Calmodulin Kinase II Mutant Mice: Deficient Long-term Potentiation and Impaired Spatial Learning A.J. Silva, Y. Wang, R. Paylor, J.M. Wehner, C.F. Stevens, and S. Tonegawa 527
Structure and Interactions of CD4 S.C. Harrison, J. Wang, Y. Yan, T. Garrett, J. Liu, U. Moebius, and E. Reinherz 541
Structural Aspects of CD4 and CD8 Involvement in the Cellular Immune Response W.A. Hendrickson, P.D. Kwong, D.J. Leahy, S.-E. Ryu, H. Yamaguchi, S. Fleury, and R.-P. Sékaly 549
Biochemical Anatomy of Antigen Processing C.A. Nelson, C.V. Harding, and E.R. Unanue 557
MHC Products: Biosybthesis, Intracellular Traffic, and "Empty" Molecules H.L. Ploegh 565
Transport and Expression of Class I MHC Glycoproteins in an Antigen-processing Mutant Cell Line E.-M. Click, K.S. Anderson, M.J. Androlewicz, M.L. Wei, and P. Cresswell 571
Dedicated Transporters for Peptide Export and Intercompartmental Traffic in the Yeast Saccharpmyces cerevisiae K. Kuchler, H.M. Göransson, M.N. Viswanathan, and J. Thorner 579
Membrane Traffic and Cytoskeletal Assembly
Each Caveola Contains Multiple Glycosyl-Phosphatidylinositol Anchored Membrane Proteins Y.-S. Ying, R.G.W. Anderson, and K.G. Rothberg 593
Molecular Flypaper, Atherosclerosis, and Host Defense: Structure and Function of the Macrophage Scavenger Receptor M. Krieger, J.M. Abrams, A. Lux, and H. Steller 605
Biogenesis of Cell-Surface Polarity in Epithelial Cells and Neurons K. Simons, P. Dupree, K. Fiedler, L. Huber, T. Kobayashi, T. Kurzchalia, V. Olkkonen, S. Pimplikar, R. Parton, and C. Dotti 611
Regulation of Epithelial Cell Polarity: A View from the Cell Surface W.J. Nelson, R. Wilson, D. Wollner, R. Mays, H. McNeill, and K. Siemers 621
Cytoplasmic Control of Cell Adhesion B. Geiger, O. Ayalon, D. Ginsberg, T. Volberg, J.L. Rodríguez Fernández Y. Yarden, and A. Ben-Ze'ev 631
Desmosomal Proteins: Mediators of Intercellular Coupling and Intermediate Filament Anchorage W.W. Franke, S.M. Troyanovsky, P.J. Koch, R. Troyanovsky, B. Fouquet, and R. E. Leube 643
Role of the Zygotic Genome in the Restructuring of the Actin Cytoskeleton at the Cycle-14 Transition during Drosophila Embryogenesis E.D. Schejter, L.S. Rose, M.A. Postner, and E. Wieschaus 653
Distinct Patterns of Actin Organization Regulated by the Small GTP-binding Proteins Rac and Rho A.J. Ridley and A. Hall 661
Summary: The Cell Surface Regulates Information Flow, Material Transport, and Cell Identity M.I. Simon 673
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