Evolution of Catalytic Function

ALTMAN, SIDNEY, Dept. of Biology, Yale University, New Haven, Connecticut ARMSTRONG, JOHN, Dept. of Drug Metabolism, Smith, Kline & French Research Ltd., Welwyn Herts, England BAKER, MICHAEL, University of California, San Diego, La Jolla BALDWIN, ANNE, Dept. of Biochemistry, Stanford University Medical Center, California BALDWIN, ROBERT, Dept. of Biochemistry, Stanford University Medical Center, California BALL, ANDREW L., Dept. of Microbiology, University of Alabama, Birmingham BARTLETT, PAUL, Dept. of Chemistry, University of California, Berkeley BASHFORD, DONALD, Dept. of Chemistry, Harvard University, Cambridge, Massachusetts BELFORD, MARLENE, Wadsworth Laboratories, New York State Dept. of Health, Albany BENKOVIC, STEPHEN, Dept. of Chemistry, Pennsylvania State University, University Park BENNER, STEVEN, Laboratory for Organic Chemistry, Swiss Federal Institute of Technology, Zurich BERG, JEREMY, Dept. of Chemistry, Johns Hopkins University, Baltimore, Maryland BIEBRICHER, CHRISTOF, Dept. of Biochemical Kinetics, Max-Planck-Institut, Göttingen, Federal Republic of Germany BLAKE, COLIN C.F., Laboratory of Molecular Biophysics, University of Oxford, England BOSWELL, Ross, Dept. of Haematological Medicine, University of Cambridge Clinical School, England BOUBLIK, MILOSLAV, Dept. of Biochemistry, Roche Institute of Molecular Biology, Nutley, New Jersey BRÄNDÉN, CARL, Dept. of Chemistry and Molecular Biology, Uppsala Biomedical Center, Sweden BRESLOW, RONALD, Dept. of Chemistry, Columbia University, New York, New York BRUICE, THOMAS, Dept. of Chemistry, University of California, Santa Barbara BURKE, JOHN, Dept. of Chemistry, Williams College, Williamstown, Massachusetts CARRELL, ROBIN, Dept. of Haematology, University of Cambridge, England CARTER, PAUL, Genentech, South San Francisco, California CAVALIER-SMITH, THOMAS, Dept. of Biophysics, Cell and Molecular Biology, Kings College, London, England CECH, THOMAS, Dept. of Chemistry and Biochemistry, University of Colorado, Boulder CEDERGREN, ROBERT, Dept. of Biochemistry, University of Montreal, Canada CHOTHIA, CYRUS, MRC Laboratory of Molecular Biology, Cambridge, England CRAIK, CHARLES, Dept. of Pharmaceutical Chemistry, University of California, San Francisco CREIGHTON, THOMAS, MRC Laboratory of Molecular Biology, Cambridge, England DARNELL, JAMES, Rockefeller University, New York, New York DAUTER, ZBIGNIEW, European Molecular Biology Laboratory, Hamburg, Federal Republic of Germany DAVIES, WAYNE, Allelix, Inc., Mississauga, Ontario, Canada DEGRADO, WILLIAM, E.I. du Pont de Nemours and Company, Wilmington, Delaware DOMANICO, PAUL, E.I. du Pont de Nemours and Company, Wilmington, Delaware DOOLITTLE, RUSSELL, Dept. of Chemistry, University of California, San Diego, La Jolla DOOLITTLE, W. FORD, Dept. of Biochemistry, Dalhousie University, Halifax, Nova Scotia, Canada DORIT, ROBERT, Dept. of Cellular and Developmental Biology, Harvard University, Cambridge, Massachusetts DOUDNA, JENNIFER, Dept. of Molecular Biology, Massachusetts General Hospital, Boston EIGEN, MANFRED, Dept. of Biophysikalische Chemie, Max-Planck-Institute, Göttingen, Federal Republic of Germany EISENBERG, DAVID, Dept. of Chemistry, University of California, Los Angeles EISENSTEIN, EDWARD, Dept. of Molecular Biology and Virus Laboratory, University of California, Berkeley EPSTEIN, LLOYD, Dept. of Biological Science, Florida State University, Tallahassee ERIKSSON, ELISABETH, Dept. of Molecular Biology, Uppsala University, Sweden FERRIS, JAMES, Dept. of Chemistry, Rensselaer Polytechnic Institute, Troy, New York FITCH, WALTER, Dept. of Biological Sciences, University of Southern California, Los Angeles FREY, PERRY, Enzyme Institute, University of Wisconsin, Madison GARDELL, STEPHEN, Dept. of Biological Chemistry, Merck, Sharpe & Dohme Research Laboratories, West Point, Pennsylvania GERBI, SUSAN, Division of Biology and Medicine, Brown University, Providence, Rhode Island GILBERT, WALTER, Dept. of Cellular and Developmental Biology, Harvard University, Cambridge, Massachusetts GO, MITIKO, Dept. of Biology, Kyushu University, Higashi-ku Fukuoka-shi, Japan GOODMAN, MORRIS, Anatomy Department, Wayne State University School of Medicine, Detroit, Michigan GRABOWSKI, PAULA, Center for Cancer Research, Massachusetts Institute of Technology, Cambridge GREGORY, STEVEN, Dept. of Experimental Biology, Roswell Park Memorial Institute, Buffalo, New York GUMPORT, RICHARD, Dept. of Biochemistry, University of Illinois, Urbana HACKERT, MARVIN, Dept. of Chemistry, University of Texas, Austin HALL, TIMOTHY, Dept. of Biology, Texas A&M University, College Station HARAYAMA, SHIGEAKI, Dept. of Medical Biochemistry, University of Geneva, Switzerland HILVERT, DONALD, Dept. of Molecular Biology, Scripps Clinic and Research Foundation, La Jolla, California HINGORANI, VIJAY, Dept. of Biological Chemistry, University of Illinois, Chicago HUMPHREYS, JOHN, Dept. of Biotechnology, Miles Laboratories, Inc., Elkhart, Indiana INOUE, TAN, The Salk Institute, La Jolla, California JENCKS, WILLIAM, Dept. of Biochemistry, Brandeis University, Waltham, Massachusetts JONES, ALWYN, Dept. of Molecular Biology, University of Uppsala, Sweden JOYCE, GERALD, The Salk Institute For Biological Studies, San Diego, California JUKES, THOMAS, Space Sciences Laboratory, University of California, Berkeley JURKA, JERZY, Dept. of Biostatistics, Dana Farber Cancer Institute, Boston, Massachusetts KARPLUS, MARTIN, Dept. of Biophysics, Harvard University, Cambridge, Massachusetts KELLER, WALTER, Dept. of Cell and Molecular Biology, German Cancer Research Center, Heidelberg, Federal Republic of Germany KENDALL, DEBRA, Dept. of Bioorganic Chemistry and Biochemistry, Rockefeller University, New York, New York KIM, BYUNG-DONG, Dept. of Plant Science, University of Rhode Island, Kingston KLAR, AMAR, Cold Spring Harbor Laboratory, New York KLUG, AARON, MRC Laboratory of Molecular Biology, Cambridge, England KNOWLES, JEREMY, Dept. of Chemistry, Harvard University, Cambridge, Massachusetts KOLAKOFSKY, DANIEL, Dept. of Microbiology, University of Geneva Medical School, Switzerland KOMIVES, ELIZABETH, Dept. of Chemistry, Harvard University, Cambridge, Massachusetts KORANT, BRUCE, Dept. of Central Research and Development, E.I. du Pont de Nemours & Company, Wilmington, Delaware KOSHLAND, DANIEL, Dept. of Biochemistry, University of California, Berkeley KOSTER, HUBERT, MilliGen-Division of Millipore, Bedford, Massachusetts KREMSKY, JONATHAN, Genetics Institute, Cambridge, Massachusetts KRENITSKY, THOMAS, Dept. of Experimental Therapy, Wellcome Research Laboratories, Research Triangle Park, North Carolina KRETSINGER, ROBERT, Dept. of Biology, University of Virginia, Charlottesville KRUG, ROBERT, Dept. of Molecular Biology and Virology, Memorial Sloan-Kettering Cancer Center, New York, New York KURKINEN, MARKKU, UMDNJ-Robert Wood-Johnson Medical School, Piscataway, New Jersey LAI, MICHAEL, Dept. of Microbiology, University of Southern California School of Medicine, Los Angeles LAKE, JIM, Dept. of Biology, University of Southern California, Los Angeles LASKOWSKI, MICHAEL, JR., Dept. of Chemistry, Purdue University, West Lafayette, Indiana LERNER, RICHARD, Dept. of Molecular Biology, The Research Institute of Scripps Clinic, La Jolla, California LEVITT, MICHAEL, Dept. of Chemistry, Weizmann Institute, Rehovot, Israel LI, WEN-HSIUNG, Dept. of Demographic and Population Genetics, University of Texas Health Science Center, Houston MANDECKI, WLODEK, Abbott Laboratories, Abbott Park, Illinois MANDIYAN, VALSAN, Dept. of Biochemistry, Roche Institute of Molecular Biology, Nutley, New Jersey MARSH, LOREN, Dept. of Biology, Texas A&M University, College Station MASSEY, RICHARD, IGEN Inc., Rockville, Maryland MATTHEWS, CHARLES, Dept. of Chemistry, Pennsylvania State University, University Park MCLACHLAN, ANDREW, MRC Laboratory of Molecular Biology, Cambridge, England MERTZ, RONALD, Max-Planck-Institut für Biochemie, Martinsried, Federal Republic of Germany MICHEL, FRAN~OIS, Centre de Genetique Moleculaire du CNRS, Gif-sur-Yvette, France MILKMAN, ROGER, Dept. of Biology, University of Iowa, Iowa City MILLER, STANLEY, Dept. of Chemistry, University of California, San Diego, La Jolla MILLS, DONALD, Dept. of Genetics and Development, Columbia University College of Physicians, Surgeons, New York, New York MIYATA, TAKASHI, Dept. of Biology, Kyushu University, Fukuoka, Japan MOORE, PETER, Dept. of Chemistry, Yale University, New Haven, Connecticut MORAS, DINO, Institute de Biologie Moleculaire and Cellulaire, Strasbourg, France MOWBRAY, SHERRY, Dept. of Biochemistry, University of California, Berkeley NIERHAUS, KNUD, Max-Planck-Institut für Molekulare Genetik, Berlin, Federal Republic of Germany NINIO, JACQUES, Institut Jacques Monod, Paris, France NOLLER, HARRY, University of California, Santa Cruz NOMURA, MASAYASU, Dept. of Biochemistry, University of California, Irvine NORTH, GEOFFREY, Nature, London, England OLSEN, GARY, Dept. of Biology and Institute of Molecular and Cellular Biology, Indiana University, Bloomington ORGEL, LESLIE, Chemical Evolution Laboratory, Salk Institute for Biological Studies, San Diego, California OSAWA, SYOZO, Biology Laboratory of Molecular Genetics, Nagoya University, Japan OZEKI, HARUO, Dept. of Biophysics, Kyoto University, Japan PACE, NICK, Dept. of Biochemistry, Texas A&M University, College Station PACE, NORMAN, Dept. of Biology, Indiana University, Bloomington PEEBLES, CRAIG, Dept. of Biological Science, University of Pittsburgh, Pennsylvania PENNY, DAVID, DEI'T. of Botany and Zoology, Massey University, Palmerston North, New Zealand PERUTZ, MAX, MRC Laboratory of Molecular Biology, Cambridge, England PEISKO, GREGORY, Dept. of Chemistry, Massachusetts Institute of Technology, Cambridge PETTER, RUSSELL, Dept. of Chemistry, University of Pittsburgh, Pennsylvania PICCIRILLI, JOE, Laboratorium für Organische Chemie, ETH Zentrum, Zurich, Switzerland PILKIS, SIMON, Dept. of Physiology and Biophysics, State University New York, Stony Brook PLUCKTHUN, ANDREAAS, Dept. of Molecular Biology, Ludwig-Maximilians-Universitat, Martinsried, Federal Republic of Germany POWELL, MICHAEL, IGEN Inc., Rockville, Maryland QUIOCHO, FLORANTE, Baylor College of Medicine, Houston, Texas RAJAVASHISTH, TRIPATHI, School of Medicine, University of California, Los Angeles R.AO, NAGIARAJA, Molecular Genetics Research, Lilly Corporate Center, Indianapolis, Indiana REANNEY, DARRYL, Science Focus, East Hawthorn, Victoria, Australia REYNOLDS, FREDERICK, Oncogene Science Inc., Mineola, New York RHEINBERGER, HANS-JORO, Max-Planck-Institut für Molekulare Genetik, Berlin, Federal Republic of Germany RICHARDS, FREDERIC, Dept. of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut ROBERTUS, JON, Dept. of Chemistry, University of Texas, Austin SAAVEDRA, RAUL, Dept. of Biology, California Institute of Technology, Pasadena SANTER, MELVIN, Dept. of Biology, Haverford College, Pennsylvania SCHEINMAN, ANDREW, Dept. of Molecular Biology, University of California, Los Angeles SCHULTZ, PETER, Dept. of Chemistry, University of California, Berkeley SCHULZ, GEORG, Institut für Organische Chemie und Biochemie, Universitat Freiburg, Federal Republic of Germany SCHWARTZ, ALAN, Dept. of Exobiology, University of Nijmegen, The Netherlands SHARP, PHILLIP, Center for Cancer Research, Massachusetts Institute of Technology, Cambridge SHUB, DAVID, Dept. of Biological Sciences, State University of New York, Albany SIGLER, PAUL, Dept. of Biochemistry and Molecular Biology, University of Chicago, Illinois STACY, DAVID, St. Joseph's Hospital, Atlanta, Georgia STEITZ, THOMAS, Dept. of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut STEWART, CARO-BETH, Dept. of Biochemistry and Biophysics, University of California, San Francisco STOLZFUS, ARLIN, Dept. of Biology, University of Iowa, Iowa City STUBBE, JOANNE, Dept. of Biochemistry, University of Wisconsin, Madison SUGIMOTO, NAOKI, Dept. of Chemistry, University of Rochester, New York SYMONS, ROBERT, Dept. of Biochemistry, University of Adelaide, Australia TABAK, HENK, Dept. of Molecular Biology, University of Amsterdam, The Netherlands TAKAHASHI, TADASHI, Biotechnology Developing Center, Olympus Corporation, Lake Success, New York THILLET, JOELLE, Institut Jacques Monod, Paris, France THOMPSON, BOB, Dept. of Biology, University of Colorado, Boulder THORSNESS, PETER, Dept. of Biochemistry, University of California, Berkeley TINOCO, IGNACIO, JR., Dept. of Chemistry, University of California, Berkeley TOMITA, FUSAO, Kato Memorial Bioscience Laboratories, Kyowa Hakko Kogyo Co. Ltd., Tokyo, Japan TURNER, DOUGLAS, Dept. of Chemistry, University of Rochester, New York UHLENBECK, OLKE, Dept. of Chemistry and Biochemistry, University of Colorado, Boulder WAS, NAND, Howard Hughes Medical Institute, Structural Biology Laboratory, University of Texas, Houston WATSON, JAMES, Cold Spring Harbor Laboratory, New York WEINER, ALAN, Dept. of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, Connecticut WEISS, ROBERT, Howard Hughes Medical Institute, University of Utah, Salt Lake City WELLS, JAMES, Dept. of Biocatalysis, Genentech, South San Francisco, California WERTZ, GAIL, Dept. of Microbiology, University of Alabama, Birmingham WESTHEIMER, FRANK, Dept. of Chemistry, Harvard University, Cambridge, Massachusetts WILLS, PETER, Dept. of Physics, University of Auckland, New Zealand WIMMER, ECKARD, Dept. of Microbiology, State University New York, Stony Brook YANAGAWA, HIROSHI, Mitsubishi-Kasei Institute of Life Sciences, Tokyo, Japan YONATH, ADA, Dept. of Structural Chemistry, Weizmann Institute, Rehovot, Israel ZARLING, DAVID, Dept. of Molecular Biology, SRI International, Menlo Park, California