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 L: Molecular Biology of Development 1985 |
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From left: Dr. Sydney Brenner, Dr. Francois Jacob, Dr. Seymour Benzer  SYMPOSIUM SYNOPSIS LIST OF PARTICIPANTS CONTENTS OF SYMPOSIUM VOLUME PHOTOGRAPHS PUBLISHED VOLUME  |
Molecular Biology of Development
Symposium Volume L Contents
Symposium Participants v
Foreword xv
Introduction
J.B. Gurdon 1
Nuclear/Cytoplasmic Interactions in Early Development
The Mouse Egg's Receptor for Sperm: What Is It and How Does It Work? P.M. Was- sarman, J.D. Bleil, H.M. Florman, J.M. Greve, R..J. Roller, G.S. Salzmann, and F G. Samuels 11
Localized Maternal mRNAs in Xenopus laevis Eggs D.L. Weeks, M.R. Rebagliati, R.P Harvey, and D.A. Melton 21
Altered Morphogenesis and Its Effects on Gene Activity in Xenopus laevis Embryos M Jamrich, T.D. Sargent, and I.B. Dawid 31
Germ Plasm and Germ Cell Determination in Xenopus laevis as Studied by Cell Trans- plantation Analysis C. C. Wylie, S. Holwill, M. O'Driscoll, A. Snape, and J. Heasman 37
Nuclear Transfer in Mouse Embryos: Activation of the Embryonic Genome D. Solter, J. Aronson, S.F. Gilbert, and J. McGrath 45
Molecular Analysis of the First Differentiations in the Mouse Embryo P Brulet, P Duprey, M. Vasseur, M Kaghad, D. Morello, P. Blanchet, C. Babinet, H. Conda- mine, and F. Jacob 51
Cell Determination during Early Embryogenesis of the Nematode Caenorhabditis elegans E. Schieren berg 59
Genes Affecting Early Development in Caenorhabditis elegans D. Hirsh, K.J. Kern- phues, D. T Stinchcomb, and R. Jefferson 69
Studies on the Cytoplasmic Organization of Early Drosophila Embryos K. G. Miller, T.L. Karr, D.R. Kellogg, I. Mohr, M. Walter, and B.M. Alberts 79
Developmental Expression of Cell-surface (Glyco)Proteins Involved in Gastrulation and Spicule Formation in Sea Urchin Embryos S.R. Grant, M.C. Farach, G.L. Decker, H.D. Woodward, H.A. Farach, and W.J. Lennarz 91
Lineage and Segmentation/Pattern Formation
Genes That Affect Cell Fates during the Development of Caenorhabditis elegans W. Fixsen, P. Steinberg, H. Ellis, and R. Horvitz 99
Bicaudal Mutations of Drosophila melanogaster: Alteration of Blastoderm Cell Fate J. Mohler and E.F. Wieschaus 105
Pattern Formation in the Muscles of Drosophila P.A. Lawrence 113
The Decapentaplegic Gene Complex in Drosophila melanogaster W.M. Gelbart, V.E. Irish, R.D. St. Johnston, E.M. Hoffmann, R. Blackman, D. Segal, L.M. Posa- kony, and R. Grimaila 119
Isolation and Structural Analysis of the Extra Sex Combs Gene of Drosophila E. Frei, D. Bopp, M. Burn, S. Baumgartner, J.-E. Edström, and M. Noll 127
Molecular and Genetic Analysis of the hairy Locus in Drosophila D. Ish-Horowicz, K.R. Howard, S.M. Pinchin, and P. W. Ingham 135
Genes Affecting the Segmental Subdivision of the Drosophila Embryo C. Nusslein- Volhard, H. Kluding, and G. Jürgens 145
Homeotic Mutants
Regulation of the Genes of the Bithorax Complex in Drosophila E.B. Lewis 155
Anatomy and function of the Bithorax Complex of Drosophila F. Sdnchez-Herrero, J. Casanova, S. Kerridge, and G. Morata 165
Domains of Cis-interaction in the Bithorax Complex W. Bender, B. Weiffenbach, F. Karch, and M. Peifer 173
Regulation and Products of the Ubx Domain of the Bithorax Complex D.S. Hogness, H.D. Lipshitz, P.A. Beachy, D.A. Peattie, R.B. Saint, M. Goldschmidt-Clermont, P.J. Harte, E.R. Gavis, and S.L. Helfand 181
Function and Expression of Ultrabithorax in the Drosophila Embryo M.E. Akam, A. Martinez-Arias, R. Weinzier, and C.D. Wilde 195
Genetic Control of the Spatial Pattern of Selector Gene Expression in Drosophila P . W. Ingham 201
Expression of the Homeo Box Gene Family in Drosophila M. Levine, K. Harding, C. Wedeen, H. Doyle, T. Hoey, and H. Radomska 209
Expression of the Dorsal Gene R. Steward, L. Ambrosio, and P. Schedl 223
The engrailed Locus of Drosophila melanogaster: Genetic, Developmental, and Molec- ular Studies Z. Ali, B. Drees, K.G. Coleman, E. Gustavson, T.L. Karr, L.M. Kauvar, S. J. Poole, W Speller, M. P Weir, and T Kornberg 229
Embryonic Pattern in Drosophila: The Spatial Distribution and Sequence-specific DNA Binding of engrailed Protein P.H. O'Farrell, C. Desplan, S. DiNardo, J.A. Kas- sis, J.M. Kuner, F. Sher, J. Theis, and D. Wright 235
Homeo Boxes
Homeotic Genes, the Homeo Box, and the Genetic Control of Development W.J. Gehring 243
Common Properties of Proteins Encoded by the Antennapedia Complex Genes of Dro- sophila melanogaster A. Laughon, S.B. Carroll, F.A. Storfer, P.D. Riley, and M.P. Scott 253
Homeo Box Sequences of the Antennapedia Class Are Conserved Only in Higher An- imal Genomes W McGinnis 263
The Xenopus Homeo Boxes E.M. DeRobertis, A. Fritz, J. Goetz, G. Martin, I. W Mattaj, F. Salo, G.D. Smith, C. Wright, and R. Zeller 271
Mammalian Homeo Box Genes EH. Ruddle, C.P Hart, A. Awgulewitsch, A. Fain- sod, M. Utset, D. Dalton, N. Kerk, M. Rabin, A. Ferguson-Smith, A. Fienberg, and W. McGinnis 277
Expression of Murine Genes Containing Homeo Box Sequences during Visceral and Parietal Endoderm Differentiation of Embryonal Carcinoma Stem Cells A.M. Colbeing-Poley, S.D. Voss, and P. Gruss 285
Structure and Expression of Two Classes of Mammalian Homeo-box-containing Genes A. Joyner, C. Hauser, T. Kornberg, R. Tjian and G. Martin 291
Human cDNA Clones Containing Homeo Box Sequences F. Boncinelli, A. Simeone, A. LaVolpe, A. Faiella, V. Fidanza, D. Acampora, and L. Scotto 301
Tissue Specificity/Position Effects
The Ac and Spin Controlling Element Families in Maize J. Banks, J. Kingsbury, V. Raboy, J. W. Schiefelbein, O. Nelson, and N. Fedoroff 307
Regulation of TcJ Transposable Elements in Caenorhabditis elegans S. W Emmons, K. Ruan, A. Levitt, and L. Yesner 313
Lineage-specific Gene Expression in the Sea Urchin Embryo E.H. Davidson, C.N. Flytzan is, J.J. Lee, J.J. Robinson, S.J. Rose III, and H.M. Sucov 321
Germ Line Specificity of P-element Transposition and Some Novel Patterns of Expres- sion of Transduced Copies of the white Gene G.M. Rubin, T. Hazelrigg, R.E. Karess, F.A. Laski, T. Laverty, R. Levis, D.C. Rio, F.A.. Spencer, and C.S. Zuker 329
On the Molecular Basis of Transvection Effects and the Regulation of Transcription Z. Zachar, C.H. Chapman, and P.M. Bingham 337
The 68C Glue Puff of Drosophila E.M. Meyerowitz, M.A. Crosby, M.D. Garfinkel, C.H. Martin, P.H. Mathers, and K. VijayRaghavan 347
Hybrid Genes in the Study of Glue Gene Regulation in Drosophila M. Bourouis and G. Richards 355
Expression of Genes Introduced into Transgenic Mice
Developmental Regulation of Human Globin Genes in Transgenic Mice F Costantini, G. Radice, I Magram, G. Stamatoyannopoulos, T Papayannopoulou, and K. Chada 361
Regulated Expression of a-Fetoprotein Genes in Transgenic Mice R. Krumlauf, R.E. Hammer, R. Brinster, V.M. Chapman, and S.M Tilghman 371
Use of Gene Transfer to Increase Animal Growth R.E. Hammer, R.L. Brinster, and R.D. Palmiter 379
Inducible and Developmental Control of Neuroendocrine Genes R.M. Evans, C. Weinberger, S. Hollenberg, L. Swanson, C. Nelson, and M.G. Rosenfeld 389
Elastase I Promoter Directs Expression of Human Growth Hormone and SV40 T An- tigen Genes to Pancreatic Acinar Cells in Transgenic Mice D.M. Ornitz, R.D. Palmiter, A. Messing, R.E. Hammer, C.A. Pinkert, and R.L. Brinster 399
Promoter Sequences of Murine aA Crystallin, Murine a2(I) Collagen or of Avian Sar- coma Virus Genes Linked to the Bacterial Chloramphenicol Acetyl Transferase Gene Direct Tissue-specific Patterns of Chloramphenicol Acetyl Transferase Expression in Transgenic Mice H. Westphal, P.A. Overbeek, J.S. Khillan, A.B. Chepelinsky, A. Schmidt, K.A. Mahon, K.E. Bernstein, J. Piatigorsky, and B. de Crombrugghe 411
Studies of Immunodifferentiation using Transgenic Mice D. Baltimore, R. Gros- schedl, D. Weaver, F. Costantini, and T. Imanishi-Kari 417
Transfer and Regulation of Expression of Chimeric Genes in Plants J. Schell, H. Kaulen, F. Kreuzaler, P. Eckes, S. Rosahl, L. Willmitzer, A. Spena, B. Baker, L. Herrera-Estrella, and N. Fedoroff 421
Transgenic Plants R..B. Horsch, S.G. Rogers, and R. T Fraley 433
Induced Developmental Defects
Retroviruses and Insertional Mutagenesis R. Jaenisch, M Breindl, K. Harbers, D. Jähner, and J. Löhler 439
Early Developmental Mutations Due to DNA Rearrangements in Transgenic Mouse Embryos L. Covarrubias, Y. Nishida, and B. Mintz 447
An Insertional Mutation in a Transgenic Mouse Line Results in Developmental Arrest at Day 5 of Gestation W.H. Mark, K. Signorelli, and F. Lacy 453
Molecular Analysis of Krüppei, a Segmentation Gene of Drosophila melanogaster H. JäckIe, U.B. Rosenberg, A. Preiss, E. Seifert, D. Knipple, A. Kienlin, and R. Leh- mann 465
Genetics of Polyamine Synthesis in Tobacco: Developmental Switches in the Flower R.L. Malmberg, I Mclndoo, A.C. Hiatt, and B.A. Lowe 475
Control of Gene Expression
spoOH: A Developmental Regulatory Gene for Promoter Utilization in Bacillus subtilis P Zuber and R. Losick 483
Constitutive and Coordinately Regulated Transcription of Yeast Genes: Promoter Ele- ments, Positive and Negative Regulatory Sites, and DNA Binding Proteins K. Struhl, W Chen, D.E. Hill, LA. Hope, and MA. Qettinger 489
A Simple Gene with a Complex Pattern of Transcription: The Alcohol Dehydrogenase Gene of Drosophila melanogaster C. Savakis and M Ashburner 505
Identification of DNA Sequences Required for the Regulation of Drosophila Alcohol Dehydrogenase Gene Expression J.W. Posakony, J.A. Fischer, and T. Maniatis 515
Developmental Control of Drosophila Yolk Protein 1 Gene by cis-Acting DNA Elements P.C. Wensink, B. Shepherd, M.J. Garabedian, and M -C. Hung 521
Localization of Sequences Regulating Drosophila Chorion Gene Amplification and Expression L. Kalfayan, T. Orr- Weaver, S. Parks, B. Wakimoto, D. de Cicco, and A. Spradling 527
Studies on the Developmentally Regulated Expression and Amplification of Insect Chorion Genes EC. Kafatos, S.A. Mitsialis, N. Spoerel, B. Mariani, J.R. Lin- gappa, and C. Delidakis 537
The Molecular Basis of Differential Gene Expression of Two 5S RNA Genes D.D. Brown and M.S. Schlissel 549
Symbiotic Nitrogen Fixation: Developmental Genetics of Nodule Formation N. Lang- Unnasch, K. Dunn, and F.M. Ausubel 555
Sex Determination
Master Regulatory Loci in Yeast and Lambda L Herskowitz 565
Aspects of Dosage Compensation and Sex Determination in Caenorhabditis elegans W.B. Wood, P. Meneely, P. Schedin, and L. Donahue 575
Sex Determination Pathway in the Nematode Caenorhabditis elegans: Variations on a Theme I Hodgkin, T. Doniach, and M Shen 585
Sex-lethal, A Link between Sex Determination and Sexual Differentiation in Droso- phila melanogaster E.M Maine, H.K. Salz, P. Schedl, and T. W. Cline 595
Control of Sexual Differentiation in Drosophila melanogaster J.M. Belote, M.B. McKeown, D.J. Andrew, T.N. Scott, and B.S. Baker 605
A Single Principle for Sex Determination in Insects R. Nöthiger and M. Steinmann- Zwicky 615
Sex Determination in Mice A. McLaren 623
Cell-cycle Effects
Genetic and Molecular Analysis of Division Control in Yeast S.I. Reed, M.A. de Barros Lopes, J. Ferguson, J.A. Hadwiger, J-Y Ho, R. Horwitz, C.A. Jones, A. T. Lorincz, MD. Mendenhall, T.A. Peterson, S. Richardson, and C. Wittenburg 627
Control of Sexual Differentiation by the ran1 + Gene in Fission Yeast D. Beach 635
Regulation of the Yeast HO Gene L. Breeden and K. Nasmyth 643
The Role of Mitotic Factors in Regulating the Timing of the Midblastula Transition in Xenopus J. Newport, T. Spann, J. Kanki, and D. Forbes 651
Chromosome Replication in Early Xenopus Embryos R.A. Laskey, S.E. Kearsey, M. Mechali, C. Dingwall, A.D. Mills, S.M Dilworth, and J. Kleinschmidt 657
Regulation of Histone Gene Expression M Busslinger, D. Schümperli, and M.L. Birnstiel 665
Pluripotent Cells/Oncogenes
A Comparison of Several Lines of Transgenic Mice Containing the SV40 Early Genes T. Van Dyke, C. Finlay, and A.J. Levine 671
Persistence and Transmission in the Mouse of Autonomous Plasmids Derived from Polyoma Virus M Rassoulzadegan and J. Vailly 679
The Ability of EK Cells to Form Chimeras after Selection of Clones in G418 and Some Observations on the Integration of Retroviral Vector Proviral DNA into EK Cells M.J. Evans, A. Bradley, M.R. Kuehn, and E.J. Robertson 685
Gene Transfer into Murine Stem Cells and Mice using Retroviral Vectors E.F. Wag- ner, G. Keller, E. Gilboa, U. Rüther, and C. Stewart 691
The Regulation of Gene Expression in Murine Teratocarcinoma Cells C.M. Gorman, D.P. Lane, C.J. Watson, and P.W.J. Rigby 701
Transformation of Embryonic Stem Cells with a Human Type-Il Collagen Gene and Its Expression in Chimeric Mice R.H. Lovell-Badge, A.E. Bygrave, A. Bradley, E. Robertson, MI Evans, and K.S.E. Cheah 707
Introduction of Genes into Embryonal Carcinoma Cells and Preimplantation Embryos by Retroviral Vectors J.F. Nicolas, J.L.R.. Rubenstein, C. Bonnerot, and F. Jacob 713
Conservation and Divergence of RAS Protein Function during Evolution C. Birch meier, D. Broek, T Toda, S. Powers, T. Kataoka, and M. Wigler 721
Proto-oncogenes of Drosophila melanogaster J.M. Bishop, B. Drees, A.L. Katzen, T.B. Korn berg, and M.A. Simon 727
Proto-oncogene fos Is Expressed during Development, Differentiation, and Growth J. Deschamps, R.L. Mitchell, F. Meijlink, W. Kruijer, D. Schubert, and I.M. Verma 733
Viral Enhancer Activity in Teratocarcinoma Cells P. Sassone-Corsi, D. Duboule, and P Chambon 747
Coordinate Expression of Myogenic Functions and Polyoma Virus Replication A. Felsani, R.. Maione, L. Ricci, and P. Amati 753
Cellular Differentiation
Structure and Regulated Transcription of DIRS-l: An Apparent Retrotransposon of Dictyostellium discoideum J. Cappello, K. Handelsman, S.M. Cohen, and H.F. Lodish 759
Regulation of Cell-type-specific Differentiation in Dictyostelium W.F. Loomis 769
Two Feedback Loops May Regulate Cell-type Proportions in Dictyostelium H. Mac Williams, A. Blaschke, and I. Prause 779
cAmp Receptors Controlling Cell-Cell Interactions in the Development of Dictyostelium P. Klein, D. Fontana, B. Knox, A. Theibert, and P. Devreotes 787
Regulation of Cell-type-specific Gene Expression in Dictyostelium R. Gomer, S. Datta, M. Mehdy, T. Crowley, A. Sivertson, W. Nellen, C. Reymond, S. Mann, and R.A. Firtel 801
Early Dictyostelium Development: Control Mechanisms Bypassed by Sequential Mutagenesis G. Gerisch, J. Hagmann, P. Hirth, C. Rossier, U. Weinhart, and M. Westphal 813
Cell Interactions Govern the Temporal Pattern of Myxococcus Development D. Kai- ser, L. Kroos, and A. Kuspa 823
Temporal and Spatial Control of Flagellar and Chemotaxis Gene Expression during Caulobacter Cell Differentiation R. Champer, R. Bryan, S.L. Gomes, M. Pur- ucker, and L. Shapiro 831
Developmental Neurobiology
Molecular Genetics of Drosophila Neurogenesis B. Yedvobnick, M.A.T. Muskavitch, K.A.. Wharton, M.E. Halpern, E. Paul, B.G. Grimwade, and S. Artavanis-Tsa konas 841
Gene Expression in Differentiating and Transdifferentiating Neural Crest Cells D.J. Anderson, R.. Stein, and R.. Axel 855
A Biological Clock in Drosophila M. W. Young, F.R.. Jackson, H.S. Shin, and T.A.. Bargiello 865
Cell Adhesion Molecule Expression and the Regulation of Morphogenesis G.M. Edel- man 877
Neurogenesis in Grasshopper and fushi tarazu Drosophila Embryos C. Q. Doe and Corey S. Goodman 891
Summary
G.M. Rubin 905
Foreword xv
Introduction
J.B. Gurdon 1
Nuclear/Cytoplasmic Interactions in Early Development
The Mouse Egg's Receptor for Sperm: What Is It and How Does It Work? P.M. Was- sarman, J.D. Bleil, H.M. Florman, J.M. Greve, R..J. Roller, G.S. Salzmann, and F G. Samuels 11
Localized Maternal mRNAs in Xenopus laevis Eggs D.L. Weeks, M.R. Rebagliati, R.P Harvey, and D.A. Melton 21
Altered Morphogenesis and Its Effects on Gene Activity in Xenopus laevis Embryos M Jamrich, T.D. Sargent, and I.B. Dawid 31
Germ Plasm and Germ Cell Determination in Xenopus laevis as Studied by Cell Trans- plantation Analysis C. C. Wylie, S. Holwill, M. O'Driscoll, A. Snape, and J. Heasman 37
Nuclear Transfer in Mouse Embryos: Activation of the Embryonic Genome D. Solter, J. Aronson, S.F. Gilbert, and J. McGrath 45
Molecular Analysis of the First Differentiations in the Mouse Embryo P Brulet, P Duprey, M. Vasseur, M Kaghad, D. Morello, P. Blanchet, C. Babinet, H. Conda- mine, and F. Jacob 51
Cell Determination during Early Embryogenesis of the Nematode Caenorhabditis elegans E. Schieren berg 59
Genes Affecting Early Development in Caenorhabditis elegans D. Hirsh, K.J. Kern- phues, D. T Stinchcomb, and R. Jefferson 69
Studies on the Cytoplasmic Organization of Early Drosophila Embryos K. G. Miller, T.L. Karr, D.R. Kellogg, I. Mohr, M. Walter, and B.M. Alberts 79
Developmental Expression of Cell-surface (Glyco)Proteins Involved in Gastrulation and Spicule Formation in Sea Urchin Embryos S.R. Grant, M.C. Farach, G.L. Decker, H.D. Woodward, H.A. Farach, and W.J. Lennarz 91
Lineage and Segmentation/Pattern Formation
Genes That Affect Cell Fates during the Development of Caenorhabditis elegans W. Fixsen, P. Steinberg, H. Ellis, and R. Horvitz 99
Bicaudal Mutations of Drosophila melanogaster: Alteration of Blastoderm Cell Fate J. Mohler and E.F. Wieschaus 105
Pattern Formation in the Muscles of Drosophila P.A. Lawrence 113
The Decapentaplegic Gene Complex in Drosophila melanogaster W.M. Gelbart, V.E. Irish, R.D. St. Johnston, E.M. Hoffmann, R. Blackman, D. Segal, L.M. Posa- kony, and R. Grimaila 119
Isolation and Structural Analysis of the Extra Sex Combs Gene of Drosophila E. Frei, D. Bopp, M. Burn, S. Baumgartner, J.-E. Edström, and M. Noll 127
Molecular and Genetic Analysis of the hairy Locus in Drosophila D. Ish-Horowicz, K.R. Howard, S.M. Pinchin, and P. W. Ingham 135
Genes Affecting the Segmental Subdivision of the Drosophila Embryo C. Nusslein- Volhard, H. Kluding, and G. Jürgens 145
Homeotic Mutants
Regulation of the Genes of the Bithorax Complex in Drosophila E.B. Lewis 155
Anatomy and function of the Bithorax Complex of Drosophila F. Sdnchez-Herrero, J. Casanova, S. Kerridge, and G. Morata 165
Domains of Cis-interaction in the Bithorax Complex W. Bender, B. Weiffenbach, F. Karch, and M. Peifer 173
Regulation and Products of the Ubx Domain of the Bithorax Complex D.S. Hogness, H.D. Lipshitz, P.A. Beachy, D.A. Peattie, R.B. Saint, M. Goldschmidt-Clermont, P.J. Harte, E.R. Gavis, and S.L. Helfand 181
Function and Expression of Ultrabithorax in the Drosophila Embryo M.E. Akam, A. Martinez-Arias, R. Weinzier, and C.D. Wilde 195
Genetic Control of the Spatial Pattern of Selector Gene Expression in Drosophila P . W. Ingham 201
Expression of the Homeo Box Gene Family in Drosophila M. Levine, K. Harding, C. Wedeen, H. Doyle, T. Hoey, and H. Radomska 209
Expression of the Dorsal Gene R. Steward, L. Ambrosio, and P. Schedl 223
The engrailed Locus of Drosophila melanogaster: Genetic, Developmental, and Molec- ular Studies Z. Ali, B. Drees, K.G. Coleman, E. Gustavson, T.L. Karr, L.M. Kauvar, S. J. Poole, W Speller, M. P Weir, and T Kornberg 229
Embryonic Pattern in Drosophila: The Spatial Distribution and Sequence-specific DNA Binding of engrailed Protein P.H. O'Farrell, C. Desplan, S. DiNardo, J.A. Kas- sis, J.M. Kuner, F. Sher, J. Theis, and D. Wright 235
Homeo Boxes
Homeotic Genes, the Homeo Box, and the Genetic Control of Development W.J. Gehring 243
Common Properties of Proteins Encoded by the Antennapedia Complex Genes of Dro- sophila melanogaster A. Laughon, S.B. Carroll, F.A. Storfer, P.D. Riley, and M.P. Scott 253
Homeo Box Sequences of the Antennapedia Class Are Conserved Only in Higher An- imal Genomes W McGinnis 263
The Xenopus Homeo Boxes E.M. DeRobertis, A. Fritz, J. Goetz, G. Martin, I. W Mattaj, F. Salo, G.D. Smith, C. Wright, and R. Zeller 271
Mammalian Homeo Box Genes EH. Ruddle, C.P Hart, A. Awgulewitsch, A. Fain- sod, M. Utset, D. Dalton, N. Kerk, M. Rabin, A. Ferguson-Smith, A. Fienberg, and W. McGinnis 277
Expression of Murine Genes Containing Homeo Box Sequences during Visceral and Parietal Endoderm Differentiation of Embryonal Carcinoma Stem Cells A.M. Colbeing-Poley, S.D. Voss, and P. Gruss 285
Structure and Expression of Two Classes of Mammalian Homeo-box-containing Genes A. Joyner, C. Hauser, T. Kornberg, R. Tjian and G. Martin 291
Human cDNA Clones Containing Homeo Box Sequences F. Boncinelli, A. Simeone, A. LaVolpe, A. Faiella, V. Fidanza, D. Acampora, and L. Scotto 301
Tissue Specificity/Position Effects
The Ac and Spin Controlling Element Families in Maize J. Banks, J. Kingsbury, V. Raboy, J. W. Schiefelbein, O. Nelson, and N. Fedoroff 307
Regulation of TcJ Transposable Elements in Caenorhabditis elegans S. W Emmons, K. Ruan, A. Levitt, and L. Yesner 313
Lineage-specific Gene Expression in the Sea Urchin Embryo E.H. Davidson, C.N. Flytzan is, J.J. Lee, J.J. Robinson, S.J. Rose III, and H.M. Sucov 321
Germ Line Specificity of P-element Transposition and Some Novel Patterns of Expres- sion of Transduced Copies of the white Gene G.M. Rubin, T. Hazelrigg, R.E. Karess, F.A. Laski, T. Laverty, R. Levis, D.C. Rio, F.A.. Spencer, and C.S. Zuker 329
On the Molecular Basis of Transvection Effects and the Regulation of Transcription Z. Zachar, C.H. Chapman, and P.M. Bingham 337
The 68C Glue Puff of Drosophila E.M. Meyerowitz, M.A. Crosby, M.D. Garfinkel, C.H. Martin, P.H. Mathers, and K. VijayRaghavan 347
Hybrid Genes in the Study of Glue Gene Regulation in Drosophila M. Bourouis and G. Richards 355
Expression of Genes Introduced into Transgenic Mice
Developmental Regulation of Human Globin Genes in Transgenic Mice F Costantini, G. Radice, I Magram, G. Stamatoyannopoulos, T Papayannopoulou, and K. Chada 361
Regulated Expression of a-Fetoprotein Genes in Transgenic Mice R. Krumlauf, R.E. Hammer, R. Brinster, V.M. Chapman, and S.M Tilghman 371
Use of Gene Transfer to Increase Animal Growth R.E. Hammer, R.L. Brinster, and R.D. Palmiter 379
Inducible and Developmental Control of Neuroendocrine Genes R.M. Evans, C. Weinberger, S. Hollenberg, L. Swanson, C. Nelson, and M.G. Rosenfeld 389
Elastase I Promoter Directs Expression of Human Growth Hormone and SV40 T An- tigen Genes to Pancreatic Acinar Cells in Transgenic Mice D.M. Ornitz, R.D. Palmiter, A. Messing, R.E. Hammer, C.A. Pinkert, and R.L. Brinster 399
Promoter Sequences of Murine aA Crystallin, Murine a2(I) Collagen or of Avian Sar- coma Virus Genes Linked to the Bacterial Chloramphenicol Acetyl Transferase Gene Direct Tissue-specific Patterns of Chloramphenicol Acetyl Transferase Expression in Transgenic Mice H. Westphal, P.A. Overbeek, J.S. Khillan, A.B. Chepelinsky, A. Schmidt, K.A. Mahon, K.E. Bernstein, J. Piatigorsky, and B. de Crombrugghe 411
Studies of Immunodifferentiation using Transgenic Mice D. Baltimore, R. Gros- schedl, D. Weaver, F. Costantini, and T. Imanishi-Kari 417
Transfer and Regulation of Expression of Chimeric Genes in Plants J. Schell, H. Kaulen, F. Kreuzaler, P. Eckes, S. Rosahl, L. Willmitzer, A. Spena, B. Baker, L. Herrera-Estrella, and N. Fedoroff 421
Transgenic Plants R..B. Horsch, S.G. Rogers, and R. T Fraley 433
Induced Developmental Defects
Retroviruses and Insertional Mutagenesis R. Jaenisch, M Breindl, K. Harbers, D. Jähner, and J. Löhler 439
Early Developmental Mutations Due to DNA Rearrangements in Transgenic Mouse Embryos L. Covarrubias, Y. Nishida, and B. Mintz 447
An Insertional Mutation in a Transgenic Mouse Line Results in Developmental Arrest at Day 5 of Gestation W.H. Mark, K. Signorelli, and F. Lacy 453
Molecular Analysis of Krüppei, a Segmentation Gene of Drosophila melanogaster H. JäckIe, U.B. Rosenberg, A. Preiss, E. Seifert, D. Knipple, A. Kienlin, and R. Leh- mann 465
Genetics of Polyamine Synthesis in Tobacco: Developmental Switches in the Flower R.L. Malmberg, I Mclndoo, A.C. Hiatt, and B.A. Lowe 475
Control of Gene Expression
spoOH: A Developmental Regulatory Gene for Promoter Utilization in Bacillus subtilis P Zuber and R. Losick 483
Constitutive and Coordinately Regulated Transcription of Yeast Genes: Promoter Ele- ments, Positive and Negative Regulatory Sites, and DNA Binding Proteins K. Struhl, W Chen, D.E. Hill, LA. Hope, and MA. Qettinger 489
A Simple Gene with a Complex Pattern of Transcription: The Alcohol Dehydrogenase Gene of Drosophila melanogaster C. Savakis and M Ashburner 505
Identification of DNA Sequences Required for the Regulation of Drosophila Alcohol Dehydrogenase Gene Expression J.W. Posakony, J.A. Fischer, and T. Maniatis 515
Developmental Control of Drosophila Yolk Protein 1 Gene by cis-Acting DNA Elements P.C. Wensink, B. Shepherd, M.J. Garabedian, and M -C. Hung 521
Localization of Sequences Regulating Drosophila Chorion Gene Amplification and Expression L. Kalfayan, T. Orr- Weaver, S. Parks, B. Wakimoto, D. de Cicco, and A. Spradling 527
Studies on the Developmentally Regulated Expression and Amplification of Insect Chorion Genes EC. Kafatos, S.A. Mitsialis, N. Spoerel, B. Mariani, J.R. Lin- gappa, and C. Delidakis 537
The Molecular Basis of Differential Gene Expression of Two 5S RNA Genes D.D. Brown and M.S. Schlissel 549
Symbiotic Nitrogen Fixation: Developmental Genetics of Nodule Formation N. Lang- Unnasch, K. Dunn, and F.M. Ausubel 555
Sex Determination
Master Regulatory Loci in Yeast and Lambda L Herskowitz 565
Aspects of Dosage Compensation and Sex Determination in Caenorhabditis elegans W.B. Wood, P. Meneely, P. Schedin, and L. Donahue 575
Sex Determination Pathway in the Nematode Caenorhabditis elegans: Variations on a Theme I Hodgkin, T. Doniach, and M Shen 585
Sex-lethal, A Link between Sex Determination and Sexual Differentiation in Droso- phila melanogaster E.M Maine, H.K. Salz, P. Schedl, and T. W. Cline 595
Control of Sexual Differentiation in Drosophila melanogaster J.M. Belote, M.B. McKeown, D.J. Andrew, T.N. Scott, and B.S. Baker 605
A Single Principle for Sex Determination in Insects R. Nöthiger and M. Steinmann- Zwicky 615
Sex Determination in Mice A. McLaren 623
Cell-cycle Effects
Genetic and Molecular Analysis of Division Control in Yeast S.I. Reed, M.A. de Barros Lopes, J. Ferguson, J.A. Hadwiger, J-Y Ho, R. Horwitz, C.A. Jones, A. T. Lorincz, MD. Mendenhall, T.A. Peterson, S. Richardson, and C. Wittenburg 627
Control of Sexual Differentiation by the ran1 + Gene in Fission Yeast D. Beach 635
Regulation of the Yeast HO Gene L. Breeden and K. Nasmyth 643
The Role of Mitotic Factors in Regulating the Timing of the Midblastula Transition in Xenopus J. Newport, T. Spann, J. Kanki, and D. Forbes 651
Chromosome Replication in Early Xenopus Embryos R.A. Laskey, S.E. Kearsey, M. Mechali, C. Dingwall, A.D. Mills, S.M Dilworth, and J. Kleinschmidt 657
Regulation of Histone Gene Expression M Busslinger, D. Schümperli, and M.L. Birnstiel 665
Pluripotent Cells/Oncogenes
A Comparison of Several Lines of Transgenic Mice Containing the SV40 Early Genes T. Van Dyke, C. Finlay, and A.J. Levine 671
Persistence and Transmission in the Mouse of Autonomous Plasmids Derived from Polyoma Virus M Rassoulzadegan and J. Vailly 679
The Ability of EK Cells to Form Chimeras after Selection of Clones in G418 and Some Observations on the Integration of Retroviral Vector Proviral DNA into EK Cells M.J. Evans, A. Bradley, M.R. Kuehn, and E.J. Robertson 685
Gene Transfer into Murine Stem Cells and Mice using Retroviral Vectors E.F. Wag- ner, G. Keller, E. Gilboa, U. Rüther, and C. Stewart 691
The Regulation of Gene Expression in Murine Teratocarcinoma Cells C.M. Gorman, D.P. Lane, C.J. Watson, and P.W.J. Rigby 701
Transformation of Embryonic Stem Cells with a Human Type-Il Collagen Gene and Its Expression in Chimeric Mice R.H. Lovell-Badge, A.E. Bygrave, A. Bradley, E. Robertson, MI Evans, and K.S.E. Cheah 707
Introduction of Genes into Embryonal Carcinoma Cells and Preimplantation Embryos by Retroviral Vectors J.F. Nicolas, J.L.R.. Rubenstein, C. Bonnerot, and F. Jacob 713
Conservation and Divergence of RAS Protein Function during Evolution C. Birch meier, D. Broek, T Toda, S. Powers, T. Kataoka, and M. Wigler 721
Proto-oncogenes of Drosophila melanogaster J.M. Bishop, B. Drees, A.L. Katzen, T.B. Korn berg, and M.A. Simon 727
Proto-oncogene fos Is Expressed during Development, Differentiation, and Growth J. Deschamps, R.L. Mitchell, F. Meijlink, W. Kruijer, D. Schubert, and I.M. Verma 733
Viral Enhancer Activity in Teratocarcinoma Cells P. Sassone-Corsi, D. Duboule, and P Chambon 747
Coordinate Expression of Myogenic Functions and Polyoma Virus Replication A. Felsani, R.. Maione, L. Ricci, and P. Amati 753
Cellular Differentiation
Structure and Regulated Transcription of DIRS-l: An Apparent Retrotransposon of Dictyostellium discoideum J. Cappello, K. Handelsman, S.M. Cohen, and H.F. Lodish 759
Regulation of Cell-type-specific Differentiation in Dictyostelium W.F. Loomis 769
Two Feedback Loops May Regulate Cell-type Proportions in Dictyostelium H. Mac Williams, A. Blaschke, and I. Prause 779
cAmp Receptors Controlling Cell-Cell Interactions in the Development of Dictyostelium P. Klein, D. Fontana, B. Knox, A. Theibert, and P. Devreotes 787
Regulation of Cell-type-specific Gene Expression in Dictyostelium R. Gomer, S. Datta, M. Mehdy, T. Crowley, A. Sivertson, W. Nellen, C. Reymond, S. Mann, and R.A. Firtel 801
Early Dictyostelium Development: Control Mechanisms Bypassed by Sequential Mutagenesis G. Gerisch, J. Hagmann, P. Hirth, C. Rossier, U. Weinhart, and M. Westphal 813
Cell Interactions Govern the Temporal Pattern of Myxococcus Development D. Kai- ser, L. Kroos, and A. Kuspa 823
Temporal and Spatial Control of Flagellar and Chemotaxis Gene Expression during Caulobacter Cell Differentiation R. Champer, R. Bryan, S.L. Gomes, M. Pur- ucker, and L. Shapiro 831
Developmental Neurobiology
Molecular Genetics of Drosophila Neurogenesis B. Yedvobnick, M.A.T. Muskavitch, K.A.. Wharton, M.E. Halpern, E. Paul, B.G. Grimwade, and S. Artavanis-Tsa konas 841
Gene Expression in Differentiating and Transdifferentiating Neural Crest Cells D.J. Anderson, R.. Stein, and R.. Axel 855
A Biological Clock in Drosophila M. W. Young, F.R.. Jackson, H.S. Shin, and T.A.. Bargiello 865
Cell Adhesion Molecule Expression and the Regulation of Morphogenesis G.M. Edel- man 877
Neurogenesis in Grasshopper and fushi tarazu Drosophila Embryos C. Q. Doe and Corey S. Goodman 891
Summary
G.M. Rubin 905
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