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 XLVIII: Molecular Neurobiology 1983 |
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From left: Dr. Michael Raftery, Dr. Robert Stroud, Dr. James Watson, Dr. Klaus Weber  SYMPOSIUM SYNOPSIS LIST OF PARTICIPANTS CONTENTS OF SYMPOSIUM VOLUME PHOTOGRAPHS PUBLISHED VOLUME  |
Molecular Neurobiology
Symposium Volume XLVIII Contents
Symposium Participants v
Foreword xiii
Part 1
Acetyicholine Receptor and Its Channel
The Arrangement and Functions of the Chains of the Acetylcholine Receptor of Torpedo Electric Tissue A. Karlin, R. Cox, R. -R. Kaldany, P. Lobel, and E. Holtzman 1
Subunit Organization and Structure of an Acetylcholine Receptor R. H. Fairclough, J. Finer-Moore, R. A. Love, K. Krisrofferson, P. J. Desmeules, and R, .M. Stroud 9
The Nicotinic Acetylcholine Receptor: Subunit Structure, Functional Binding Sites, and Ion Transport Properties M .A. Raftery, S.M.J. Dunn, B. M. Conti-Tronconi, D. S. Middlemas, and R.. D. Crawford 21
Allosteric Properties of the Acetyicholine Receptor Protein from Torpedo mar- morata J.-P. Changeux, F. Bon, J. Cartaud, A. Devillers-Thiéry, J. Giraudat, T. Heidmann, B. Holton, H. -O. Nghhiêm, J. -L. Popot, R. Van Rapenbusch, and S. Tzartos 35
Muscarinic Receptor Subclasses: Allosteric Interactions N.J.M. Birdsall, E. C. Hulme, and J. M. Stockton 53
Molecular Structure of the Nicotinic Acetylcholine Receptor S. Numa, M. Noda, H. Takahashi, T. Tanabe, M. Toyosato, Y. Furutani, and S. Kikyotani 57
Molecular Cloning of the Acetylcholine Receptor J. Patrick, M. Ballivet, L. Boas, T. Claudio, J. Forrest, H. Ingraham, P. Mason, S. Stengelin, S. Ueno, and S. Heinemann 71
Structure and Expression of Genomic Clones Coding for the d-Subunit of the Torpedo Acetylcholine Receptor N. D. Hershey, D. J. Noonan, K. S. Mixter, T. Claudio, and N. Davidson 79
Genomic Sequences Encoding the a-Subunit of Acetylcholine Receptor Are Conserved in Evolution M. Ballivet, P. Nef, R. Stalder, and B. Fulpius 83
Use of Monoclonal Antibodies to Study Acetylcholine Receptors from Electric Organs, Muscle, and Brain and the Autoimmune Response to Receptor in Myasthenia Gravis J. Lindstrom, S. Tzartos, W. Gullick, S. Hockschwender, L. Swanson, P. Sargent, M. Jacob, and M. Montal 89
A Developmental Change in the Immunological Properties of Acetylcholine Receptors at the Rat Neuromuscular Junction Z. W. Hall, M. -P. Roisin, Y. Gu, and P.D. Gorin 101
Acetyicholine and GABA Receptors: Subunits of Central and Peripheral Receptors and Their Encoding Nucleic Acids E.A. Barnard, D. Beeson, G. Bilbe, D.A. Brown, A. Constanti, B.M. Conti-Tronconi, J.O. Dolly, S.M.J. Dunn, F. Mehraban, B.M. Richards, and T.G. Smart 109
Molecular Events in the Synthesis and Assembly of a Nicotinic Acetylcholine Recep- tor D.J. Anderson and G. Blobel 125
The Regulation of Acetylcholine Receptor Expression in Mammalian Muscle J. P. Merlie, R. Sebbane, S. Gardner, E. Olson, and J. Lindstrom 135
Sodium Channel
Inactivation of Open and Closed Sodium Channels Determined Separately R. W. Aldrich and C. F. Stevens 147
Structure and Functional Reconstitution of the Voltage-sensitive Sodium Channel from Rat Brain J.A. Talvenheimo, M.M. Tamkun, R.P. Hartshorne, D.J. Messner, R.G. Sharkey, M.R.C. Costa, and W.A. Catterall 155
The Voltage-regulated Sodium Channel from the Electroplax of Electrophorus elec- tricus W. S. Agnew, J.A. Miller, M. H. Ellisman, R.L. Rosenberg, S.A. Tomiko, and S.R. Levinson 165
Immunochemical Studies of the Voltage-sensitive Sodium Channel from the Electroplax of the Eel Electrophorous electricus L. C. Fritz, H. -P. H. Moore, M. A. Raftery, and J. P. Brockes 181
The Molecular Mechanism of Action of the b-Adrenergic Receptor M. Schramm, M. Korner, G. Neufeld, and E. Nedivi 187
Calcium and Potassium Channels
Modulation of Calcium Channels in Cultured Cardiac Cells by Isoproterenol and 8-Bromo-cAMP H. Reuter, A.B. Cachelin, I.E. De Peyer, and S. Kokubun 193
Calcium Channels: Mechanisms of b-Adrenergic Modulation of Ion Permeation R. W. Tsien, B.P. Bean, P. Hess, and M. Nowycky 201
Modulation of a Specific Potassium Channel in Sensory Neurons of Aplysia by Serotonin and cAMP-dependent Protein Phosphorylation J.S. Carmardo, M.J. Shuster, S.A. Siegelbaum, and E.R. Kandel 213
Genetic and Voltage-clamp Analysis of a Drosophila Potassium Channel L. Salkoff 221
Mutating a Gene for a Potassium Channel by Hybrid Dysgenesis: An Approach to the Cloning of the Shaker Locus in Drosophila L. Y Jan, S. Barbel, L. Timpe, C. Laf- fer, L. Salkoff, P. O'Farrell, and Y. N. Jan 233
Ion Transport by Single Receptor Channels B. Sakmann, J. Bormann, and O.P. Hamill 247
Excitable Membrane Properties of Cultured Central Nervous System Neurons and Clonal Pituitary Cells J. L. Barker, B. Dufy D. G. Owen, and M. Segal 259
Glutamate- and GABA-receptor Channels at the Locus Nerve-Muscle Junction: Noise Analysis and Single-channel Recording S. G. Cull-Candy 269
Chemical and Pharmacological Approaches to the Definition and Quantitation of Calcium Channels P.J. Gengo, E. Lochowski, D. E. Rampe, A. Rutledge, A. M. Triggle, D.J. Triggle, and R.A. Janis 279
Purification and Characterization of ATP-dependent Calcium Pumps from Synap- tosomes S.M. Goldin, S. Y Chan, D.M. Papazian, E.J. Hess, and H. Rahamimoff 287
Studies of the Na+ -K + ATPase of Skeletal Muscle and Nerve D. M. Fambrough 297
Studies on Neuronal Proteins with Recombinant DNA Techniques
Detection and Regulation of the Tyrosine Hydroxylase mRNA Levels in Rat Adrenal Medulla and Brain Tissues J. Mallet, N. Faucon Biguet, M. Buda, A. Lamouroux, and D. Samolyk 305
Cloning and Characterization of Rat-brain-specific Transcripts: Rare, Brain-specific Transcripts and Tyrosine Hydroxylase D.M. Chikaraishi, M.H. Brilliant, and E.J. Lewis 309
Dopamine-b-Hydroxylase Rat mRNA: Structure, Regulation, and Tissue Localiza- tion K. O'Malley, A. Mauron, G. Makk, D.L. Wong, R.D. Ciaranello, J.D. Barchas, and L. Kedes 319
Evidence for the Existence of Homologous Gene Coding Regions for the Catecholamine Biosynthetic Enzymes T.H. Joh, E.E. Baetge, M.E. Ross, and D.J. Reis 327
Neuron-specific Phosphoproteins as Models for Neuronal Gene Expression L.J. DeGennaro, S.D. Kanazir, W. C. Wallace, R.M. Lewis, and P. Greengard 337
Expression of Cell-type-specific Neuronal Phosphoproteins R.M. Lewis, W. C. Wallace, S.D. Kanazir, and P. Greengard 347
Studies on Voltage-operated Calcium Channels Using Radioligands R.J. Gould, K.M.M. Murphy, and S.H. Snyder 355
Molecular Aspects of Neuropeptides
Peptides in Neuronal Function-Studies Using Frog Autonomic Ganglia Y.N. Jan, C. W. Bowers, D. Branton, L. Evans, and L. Y. Jan 363
Generation of Diversity and Evolution of Opioid Peptides E. Herbert, E. Oates, G. Martens, M. Comb, H. Rosen, and M. Uhler 375
Analysis of POMC Gene Expression by Transcription Assay and In Situ Hybridization Histochemistry J. L. Roberts, J. H. Eberwine, and C. E. Gee 385
The Enkephalinergic Neuron: Implications of a Polyenkephalin Precursor J. Rossier, D. Liston, G. Patey, M. Chaminade, A.S. Foutz, A. Cupo, P. Giraud, M.P. Roisin, J. P. Henry, P. Verbanck, and J.-J. Vanderhaeghen 393
The Molecular Basis of a Neuroendocrine Fixed Action Pattern: Egg Laying in Aplysia A..C. Mahon and R. H. Scheller 405
Molecular Events in Developmental Regulation of Neuroendocrine Genes- Characterization of the Novel Neuropeptide CGRP R..M. Evans, S. Amara, and M. G. Rosenfeld 413
The Kallikrein Multigene Family: Specific Processing of Biologically Active Pep- tides J. Shine, A..J. Mason, B.A. Evans, and R..I. Richards 419
The Biosynthesis and Processing of Proteins in the Mouse 7S Nerve Growth Factor Complex T.L.J. Darling, P.E. Petrides, P. Beguin, P. Frey, E.M. Shooter, M. Selby, and W.J. Rutter 427
Sequence Homology of Human and Mouse b-NGF Subunit Genes A. Ullrich, A. Gray, C. Berman, L Coussens, and T.J. Dull 435
Part 2
Genetic Analysis of the Nervous System
Neuronal Cell Lineages in the Nematode Caenorhabditis elegans J.E. Sulston 443
Mutations That Affect Neural Cell Lineages and Cell Fates during the Development of the Nematode Caenorhabditis elegans H.R. Horvitz, P. W Steinberg, I.S. Green- wald, W. Fixsen, and H.M. Ellis 453
Genetic Expression and Postnatal Development of the Brain: Some Characteristics of Nonpolyadenylated mRNAs W.E. Hahn, N. Chaudhari, L. Beck, K. Wilber, and D. Peffley 465
Cellular Localization and Function of the Proteins Encoded by Brain-specific mRNAs J. G. Sutcliffe, R..J. Milner, and F.E. Bloom 477
Gene Expression and the Diversity of Identified Neurons L. Buck, R. Stein, M. Palaz- zolo, D. Anderson, and R. Axe 485
Chromatin Changes Accompanying Neuronal Differentiation C. C. Kuenzle, C. W. Heiz- mann, U.Hübscher, R. Hobi, G. C. Winkler, A. W. Jaeger, and G. Morgenegg 493
Neuronal Surface Molecules
Molecular and Biological Properites of a Neural Cell Adhesion Molecule U. Rutishauser 501
Structure and Modulation of Neural Cell Adhesion Molecules in Early and Late Em- bryogenesis G.M. Edelman, S. Hoffman, C.-M. Chuong, J.-P. Thiery, R. Brackenbury, W.J. Gallin, M. Grumet, M.E. Greenberg, J.J. Hemperly, C. Cohen, and B.A. Cunningham 515
Neural Surface Antigens during Nervous System Development C. Goridis, H. Deagostini-Bazin, M. Hirn, M.-R. Hirsch, G. Rougon, R. Sadoul, O.K. Langley, G. Gombos, and J. Finne 527
The Structure and Function of Myoblast Adherons D. Schubert, M. LaCorbiere, F. G. Klier, and C. Birdwell 539
Do Monoclonal Antibodies Stain Sets of Functionally Related Leech Neurons? B. Zipser, R. Stewart, T. Flanagan, M. Flaster, and E.R. Macagno 551
Cell-type Specificity and Developmental Expression of Neural Cell-surface Components Involved in Cell Interactions and of Structurally Related Molecules M. Schachner, A. Faissner, J. Kruse, J. Lindner, D. H. Meier, F. G. Rathjen, and H. Wernecke 557
Glial Cell Lineages in the Rat Optic Nerve M. C. Raff, R. H. Miller, and M. Noble 569
The Regulation of Axon Organization
Navigational Substrates for Peripheral Pioneer Growth Cones: Limb-axis Polarity Cues, Limb-segment Boundaries, and Guidepost Neurons D. Bentley and M. Caudy 573
Guidance of Neuronal Growth Cones: Selective Fasciculation in the Grasshopper Em- bryo J.A.. Raper, M.J. Bastiani, and C..S. Goodman 587
The Molecular Organization of the Leech Nervous System R..D. McKay, S. Hockfield, J. Johansen, and K. Frederiksen 599
Studies on Extracellular Matrix Components That Promote Neurite Outgrowth A. D. Lander, K Tomaselli, A.L. Calof, and L.F. Reichardt 611
The Production of a Monoclonal Antibody That Blocks the Action of a Neurite Outgrowth-promoting Factor W. D. Matthew and P. H. Patterson 625
Factors That Determine Connectivity in the Nervous System of C. elegans J. G. White, E. Southgate, J.N. Thomson, and S. Brenner 633
What Genes Are Necessary to Make an Identified Synapse? R.J. Wyman and J.B. Thomas 641
Synaptic Organization and Function
Molecular Components of the Synaptic Basal Lamina That Direct Differentiation of Regenerating Neuromuscular Junctions R.M. Nitkin, B. G. Wallace, M.E. Spira, E. W. Godfrey, and U.J. McMahan 653
The Basal Lamina of the Neuromuscular Junction J. R. Sanes and A. Y. Chiu 667
Quantitation and Purification of Neurotrophic Molecules H. Thoenen, S. Korsching, Y-A. Barde, and D. Edgar 679
Cytochemical and Physiological Properties of Sensory and Dorsal Horn Neurons That Transmit Cutaneous Sensation J. Dodd, C.E. Jahr, P.N. Hamilton, M.J.S. Heath, W.D. Matthew, and T.M. Jessell 685
Membrane Traffic in Neurons and Peptide-secreting Cells R. B. Kelly, K. M. Buckley, T.L. Burgess, S.S. Carlson, P. Caroni, J.E. Hooper, A. Katzen, H.-P. Moore, S.R. Pfeffer, and T.A. Schroer 697
Synapse Formation by Neuroblastoma Hybrid Cells M. Nirenberg, S. Wilson, H. Higashida, A. Rotter, K. Krueger, N. Busis, R. Ray, K. Kenimer, M. Adler, and H. Fukui 707
The Cellular Organization of Neurons
Neurofilaments, a Subclass of Intermediate Filaments: Structure and Expression K. Weber, G. Shaw, M. Osborn, E. Debus, and N. Geisler 717
Molecular Biology of Neuronal Geometry: Expression of Neurofilament Genes In- fluences Axonal Diameter R.J. Lasek, M. M. Oblinger, and P. F. Drake 731
Polyribosomes at the Base of Dendritic Spines of Central Nervous System Neurons- Possible Role in Synapse Construction and Modification O. Steward 745
Cell-surface Molecules That Characterize Different Stages in the Development of Cerebellar Interneurons W.B. Stallcup, L. Beasley, and J. Levine 761
Neuronal Microdifferentiation A. Matus, G. Huber, and R. Bernhardt 775
Expression of mRNA for Microtubule Proteins in the Developing Nervous System I. Ginzburg, T. Scherson, S. Rybak, Y. Kimhi, D. Neuman, M. Schwartz, and U.Z. Littauer 783
Axonally Transported Proteins in Axon Development, Maintenance, and Regenera- tion C. Baitinger, R. Cheney, D. Clements, M. Glicksman, N. Hirokawa, J. Levine, K. Meiri, C. Simon, P. Skene, and M. Willard 791
Behavior
Bacterial Chemotaxis and Molecular Neurobiology J. Adler 803
Information Processing in a Sensory System D. E. Koshland, Jr., A. F. Russo, and N.I. Gutterson 805
What Molecular Steps Determine the Time Course of the Memory for Short-term Sen- sitization in Aplysia? J. H. Schwartz, L. Bernier, V. F. Castellucci, M. Palazzolo, T. Saitoh, A. Stapleton, and E.R. Kandel 811
Classical Conditioning and Sensitization Share Aspects of the Same Molecular Cascade in Aplysia E.R. Kandel, T. Abrams, L Bemier, T.J. Carew, R.D. Hawkins, and J. H. Schwartz 821
Learning and Memory in Drosophila, Studied with Mutants E.O. Aceves-Piña, R. Booker, J.S. Duerr, M. S. Livingstone, W G. Quinn, R. F. Smith, P. P. Sziber, B. L. Tempel, and T.P. Tully 831
Aspects of Vision
Transducin and the Cyclic GMP Phosphodiesterase-Amplifier Proteins in Vision L. Stryer 841
Studies on the Light-transducing Pigment Bacteriorhodopsin RI. Dunn, N.R. Hackett, K. -S. Huang, S. Jones, H. G. Khorana, D -S. Lee, M.-I. Liao, K.-M. Lo, J. McCoy, S. Noguchi, R. Radhakrishnan, and U.L. RajBhandary 853
Monoclonal Antibodies That Label Discrete Cell Types in the Mammalian Nervous System C.J. Barnstable, K. Akagawa, R. Hofstein, and J.P. Horn 863
A Surface Antigen That Identifies Ocular Dominance Columns in the Visual Cortex and Laminar Features of the Lateral Geniculate Nucleus S. Hockfield, R. D. McKay, S. H. C. Hendry, and E.G. Jones 877
Summary
Neurobiology and Molecular Biology: The Second Encounter E.R. Kandel 891
Foreword xiii
Part 1
Acetyicholine Receptor and Its Channel
The Arrangement and Functions of the Chains of the Acetylcholine Receptor of Torpedo Electric Tissue A. Karlin, R. Cox, R. -R. Kaldany, P. Lobel, and E. Holtzman 1
Subunit Organization and Structure of an Acetylcholine Receptor R. H. Fairclough, J. Finer-Moore, R. A. Love, K. Krisrofferson, P. J. Desmeules, and R, .M. Stroud 9
The Nicotinic Acetylcholine Receptor: Subunit Structure, Functional Binding Sites, and Ion Transport Properties M .A. Raftery, S.M.J. Dunn, B. M. Conti-Tronconi, D. S. Middlemas, and R.. D. Crawford 21
Allosteric Properties of the Acetyicholine Receptor Protein from Torpedo mar- morata J.-P. Changeux, F. Bon, J. Cartaud, A. Devillers-Thiéry, J. Giraudat, T. Heidmann, B. Holton, H. -O. Nghhiêm, J. -L. Popot, R. Van Rapenbusch, and S. Tzartos 35
Muscarinic Receptor Subclasses: Allosteric Interactions N.J.M. Birdsall, E. C. Hulme, and J. M. Stockton 53
Molecular Structure of the Nicotinic Acetylcholine Receptor S. Numa, M. Noda, H. Takahashi, T. Tanabe, M. Toyosato, Y. Furutani, and S. Kikyotani 57
Molecular Cloning of the Acetylcholine Receptor J. Patrick, M. Ballivet, L. Boas, T. Claudio, J. Forrest, H. Ingraham, P. Mason, S. Stengelin, S. Ueno, and S. Heinemann 71
Structure and Expression of Genomic Clones Coding for the d-Subunit of the Torpedo Acetylcholine Receptor N. D. Hershey, D. J. Noonan, K. S. Mixter, T. Claudio, and N. Davidson 79
Genomic Sequences Encoding the a-Subunit of Acetylcholine Receptor Are Conserved in Evolution M. Ballivet, P. Nef, R. Stalder, and B. Fulpius 83
Use of Monoclonal Antibodies to Study Acetylcholine Receptors from Electric Organs, Muscle, and Brain and the Autoimmune Response to Receptor in Myasthenia Gravis J. Lindstrom, S. Tzartos, W. Gullick, S. Hockschwender, L. Swanson, P. Sargent, M. Jacob, and M. Montal 89
A Developmental Change in the Immunological Properties of Acetylcholine Receptors at the Rat Neuromuscular Junction Z. W. Hall, M. -P. Roisin, Y. Gu, and P.D. Gorin 101
Acetyicholine and GABA Receptors: Subunits of Central and Peripheral Receptors and Their Encoding Nucleic Acids E.A. Barnard, D. Beeson, G. Bilbe, D.A. Brown, A. Constanti, B.M. Conti-Tronconi, J.O. Dolly, S.M.J. Dunn, F. Mehraban, B.M. Richards, and T.G. Smart 109
Molecular Events in the Synthesis and Assembly of a Nicotinic Acetylcholine Recep- tor D.J. Anderson and G. Blobel 125
The Regulation of Acetylcholine Receptor Expression in Mammalian Muscle J. P. Merlie, R. Sebbane, S. Gardner, E. Olson, and J. Lindstrom 135
Sodium Channel
Inactivation of Open and Closed Sodium Channels Determined Separately R. W. Aldrich and C. F. Stevens 147
Structure and Functional Reconstitution of the Voltage-sensitive Sodium Channel from Rat Brain J.A. Talvenheimo, M.M. Tamkun, R.P. Hartshorne, D.J. Messner, R.G. Sharkey, M.R.C. Costa, and W.A. Catterall 155
The Voltage-regulated Sodium Channel from the Electroplax of Electrophorus elec- tricus W. S. Agnew, J.A. Miller, M. H. Ellisman, R.L. Rosenberg, S.A. Tomiko, and S.R. Levinson 165
Immunochemical Studies of the Voltage-sensitive Sodium Channel from the Electroplax of the Eel Electrophorous electricus L. C. Fritz, H. -P. H. Moore, M. A. Raftery, and J. P. Brockes 181
The Molecular Mechanism of Action of the b-Adrenergic Receptor M. Schramm, M. Korner, G. Neufeld, and E. Nedivi 187
Calcium and Potassium Channels
Modulation of Calcium Channels in Cultured Cardiac Cells by Isoproterenol and 8-Bromo-cAMP H. Reuter, A.B. Cachelin, I.E. De Peyer, and S. Kokubun 193
Calcium Channels: Mechanisms of b-Adrenergic Modulation of Ion Permeation R. W. Tsien, B.P. Bean, P. Hess, and M. Nowycky 201
Modulation of a Specific Potassium Channel in Sensory Neurons of Aplysia by Serotonin and cAMP-dependent Protein Phosphorylation J.S. Carmardo, M.J. Shuster, S.A. Siegelbaum, and E.R. Kandel 213
Genetic and Voltage-clamp Analysis of a Drosophila Potassium Channel L. Salkoff 221
Mutating a Gene for a Potassium Channel by Hybrid Dysgenesis: An Approach to the Cloning of the Shaker Locus in Drosophila L. Y Jan, S. Barbel, L. Timpe, C. Laf- fer, L. Salkoff, P. O'Farrell, and Y. N. Jan 233
Ion Transport by Single Receptor Channels B. Sakmann, J. Bormann, and O.P. Hamill 247
Excitable Membrane Properties of Cultured Central Nervous System Neurons and Clonal Pituitary Cells J. L. Barker, B. Dufy D. G. Owen, and M. Segal 259
Glutamate- and GABA-receptor Channels at the Locus Nerve-Muscle Junction: Noise Analysis and Single-channel Recording S. G. Cull-Candy 269
Chemical and Pharmacological Approaches to the Definition and Quantitation of Calcium Channels P.J. Gengo, E. Lochowski, D. E. Rampe, A. Rutledge, A. M. Triggle, D.J. Triggle, and R.A. Janis 279
Purification and Characterization of ATP-dependent Calcium Pumps from Synap- tosomes S.M. Goldin, S. Y Chan, D.M. Papazian, E.J. Hess, and H. Rahamimoff 287
Studies of the Na+ -K + ATPase of Skeletal Muscle and Nerve D. M. Fambrough 297
Studies on Neuronal Proteins with Recombinant DNA Techniques
Detection and Regulation of the Tyrosine Hydroxylase mRNA Levels in Rat Adrenal Medulla and Brain Tissues J. Mallet, N. Faucon Biguet, M. Buda, A. Lamouroux, and D. Samolyk 305
Cloning and Characterization of Rat-brain-specific Transcripts: Rare, Brain-specific Transcripts and Tyrosine Hydroxylase D.M. Chikaraishi, M.H. Brilliant, and E.J. Lewis 309
Dopamine-b-Hydroxylase Rat mRNA: Structure, Regulation, and Tissue Localiza- tion K. O'Malley, A. Mauron, G. Makk, D.L. Wong, R.D. Ciaranello, J.D. Barchas, and L. Kedes 319
Evidence for the Existence of Homologous Gene Coding Regions for the Catecholamine Biosynthetic Enzymes T.H. Joh, E.E. Baetge, M.E. Ross, and D.J. Reis 327
Neuron-specific Phosphoproteins as Models for Neuronal Gene Expression L.J. DeGennaro, S.D. Kanazir, W. C. Wallace, R.M. Lewis, and P. Greengard 337
Expression of Cell-type-specific Neuronal Phosphoproteins R.M. Lewis, W. C. Wallace, S.D. Kanazir, and P. Greengard 347
Studies on Voltage-operated Calcium Channels Using Radioligands R.J. Gould, K.M.M. Murphy, and S.H. Snyder 355
Molecular Aspects of Neuropeptides
Peptides in Neuronal Function-Studies Using Frog Autonomic Ganglia Y.N. Jan, C. W. Bowers, D. Branton, L. Evans, and L. Y. Jan 363
Generation of Diversity and Evolution of Opioid Peptides E. Herbert, E. Oates, G. Martens, M. Comb, H. Rosen, and M. Uhler 375
Analysis of POMC Gene Expression by Transcription Assay and In Situ Hybridization Histochemistry J. L. Roberts, J. H. Eberwine, and C. E. Gee 385
The Enkephalinergic Neuron: Implications of a Polyenkephalin Precursor J. Rossier, D. Liston, G. Patey, M. Chaminade, A.S. Foutz, A. Cupo, P. Giraud, M.P. Roisin, J. P. Henry, P. Verbanck, and J.-J. Vanderhaeghen 393
The Molecular Basis of a Neuroendocrine Fixed Action Pattern: Egg Laying in Aplysia A..C. Mahon and R. H. Scheller 405
Molecular Events in Developmental Regulation of Neuroendocrine Genes- Characterization of the Novel Neuropeptide CGRP R..M. Evans, S. Amara, and M. G. Rosenfeld 413
The Kallikrein Multigene Family: Specific Processing of Biologically Active Pep- tides J. Shine, A..J. Mason, B.A. Evans, and R..I. Richards 419
The Biosynthesis and Processing of Proteins in the Mouse 7S Nerve Growth Factor Complex T.L.J. Darling, P.E. Petrides, P. Beguin, P. Frey, E.M. Shooter, M. Selby, and W.J. Rutter 427
Sequence Homology of Human and Mouse b-NGF Subunit Genes A. Ullrich, A. Gray, C. Berman, L Coussens, and T.J. Dull 435
Part 2
Genetic Analysis of the Nervous System
Neuronal Cell Lineages in the Nematode Caenorhabditis elegans J.E. Sulston 443
Mutations That Affect Neural Cell Lineages and Cell Fates during the Development of the Nematode Caenorhabditis elegans H.R. Horvitz, P. W Steinberg, I.S. Green- wald, W. Fixsen, and H.M. Ellis 453
Genetic Expression and Postnatal Development of the Brain: Some Characteristics of Nonpolyadenylated mRNAs W.E. Hahn, N. Chaudhari, L. Beck, K. Wilber, and D. Peffley 465
Cellular Localization and Function of the Proteins Encoded by Brain-specific mRNAs J. G. Sutcliffe, R..J. Milner, and F.E. Bloom 477
Gene Expression and the Diversity of Identified Neurons L. Buck, R. Stein, M. Palaz- zolo, D. Anderson, and R. Axe 485
Chromatin Changes Accompanying Neuronal Differentiation C. C. Kuenzle, C. W. Heiz- mann, U.Hübscher, R. Hobi, G. C. Winkler, A. W. Jaeger, and G. Morgenegg 493
Neuronal Surface Molecules
Molecular and Biological Properites of a Neural Cell Adhesion Molecule U. Rutishauser 501
Structure and Modulation of Neural Cell Adhesion Molecules in Early and Late Em- bryogenesis G.M. Edelman, S. Hoffman, C.-M. Chuong, J.-P. Thiery, R. Brackenbury, W.J. Gallin, M. Grumet, M.E. Greenberg, J.J. Hemperly, C. Cohen, and B.A. Cunningham 515
Neural Surface Antigens during Nervous System Development C. Goridis, H. Deagostini-Bazin, M. Hirn, M.-R. Hirsch, G. Rougon, R. Sadoul, O.K. Langley, G. Gombos, and J. Finne 527
The Structure and Function of Myoblast Adherons D. Schubert, M. LaCorbiere, F. G. Klier, and C. Birdwell 539
Do Monoclonal Antibodies Stain Sets of Functionally Related Leech Neurons? B. Zipser, R. Stewart, T. Flanagan, M. Flaster, and E.R. Macagno 551
Cell-type Specificity and Developmental Expression of Neural Cell-surface Components Involved in Cell Interactions and of Structurally Related Molecules M. Schachner, A. Faissner, J. Kruse, J. Lindner, D. H. Meier, F. G. Rathjen, and H. Wernecke 557
Glial Cell Lineages in the Rat Optic Nerve M. C. Raff, R. H. Miller, and M. Noble 569
The Regulation of Axon Organization
Navigational Substrates for Peripheral Pioneer Growth Cones: Limb-axis Polarity Cues, Limb-segment Boundaries, and Guidepost Neurons D. Bentley and M. Caudy 573
Guidance of Neuronal Growth Cones: Selective Fasciculation in the Grasshopper Em- bryo J.A.. Raper, M.J. Bastiani, and C..S. Goodman 587
The Molecular Organization of the Leech Nervous System R..D. McKay, S. Hockfield, J. Johansen, and K. Frederiksen 599
Studies on Extracellular Matrix Components That Promote Neurite Outgrowth A. D. Lander, K Tomaselli, A.L. Calof, and L.F. Reichardt 611
The Production of a Monoclonal Antibody That Blocks the Action of a Neurite Outgrowth-promoting Factor W. D. Matthew and P. H. Patterson 625
Factors That Determine Connectivity in the Nervous System of C. elegans J. G. White, E. Southgate, J.N. Thomson, and S. Brenner 633
What Genes Are Necessary to Make an Identified Synapse? R.J. Wyman and J.B. Thomas 641
Synaptic Organization and Function
Molecular Components of the Synaptic Basal Lamina That Direct Differentiation of Regenerating Neuromuscular Junctions R.M. Nitkin, B. G. Wallace, M.E. Spira, E. W. Godfrey, and U.J. McMahan 653
The Basal Lamina of the Neuromuscular Junction J. R. Sanes and A. Y. Chiu 667
Quantitation and Purification of Neurotrophic Molecules H. Thoenen, S. Korsching, Y-A. Barde, and D. Edgar 679
Cytochemical and Physiological Properties of Sensory and Dorsal Horn Neurons That Transmit Cutaneous Sensation J. Dodd, C.E. Jahr, P.N. Hamilton, M.J.S. Heath, W.D. Matthew, and T.M. Jessell 685
Membrane Traffic in Neurons and Peptide-secreting Cells R. B. Kelly, K. M. Buckley, T.L. Burgess, S.S. Carlson, P. Caroni, J.E. Hooper, A. Katzen, H.-P. Moore, S.R. Pfeffer, and T.A. Schroer 697
Synapse Formation by Neuroblastoma Hybrid Cells M. Nirenberg, S. Wilson, H. Higashida, A. Rotter, K. Krueger, N. Busis, R. Ray, K. Kenimer, M. Adler, and H. Fukui 707
The Cellular Organization of Neurons
Neurofilaments, a Subclass of Intermediate Filaments: Structure and Expression K. Weber, G. Shaw, M. Osborn, E. Debus, and N. Geisler 717
Molecular Biology of Neuronal Geometry: Expression of Neurofilament Genes In- fluences Axonal Diameter R.J. Lasek, M. M. Oblinger, and P. F. Drake 731
Polyribosomes at the Base of Dendritic Spines of Central Nervous System Neurons- Possible Role in Synapse Construction and Modification O. Steward 745
Cell-surface Molecules That Characterize Different Stages in the Development of Cerebellar Interneurons W.B. Stallcup, L. Beasley, and J. Levine 761
Neuronal Microdifferentiation A. Matus, G. Huber, and R. Bernhardt 775
Expression of mRNA for Microtubule Proteins in the Developing Nervous System I. Ginzburg, T. Scherson, S. Rybak, Y. Kimhi, D. Neuman, M. Schwartz, and U.Z. Littauer 783
Axonally Transported Proteins in Axon Development, Maintenance, and Regenera- tion C. Baitinger, R. Cheney, D. Clements, M. Glicksman, N. Hirokawa, J. Levine, K. Meiri, C. Simon, P. Skene, and M. Willard 791
Behavior
Bacterial Chemotaxis and Molecular Neurobiology J. Adler 803
Information Processing in a Sensory System D. E. Koshland, Jr., A. F. Russo, and N.I. Gutterson 805
What Molecular Steps Determine the Time Course of the Memory for Short-term Sen- sitization in Aplysia? J. H. Schwartz, L. Bernier, V. F. Castellucci, M. Palazzolo, T. Saitoh, A. Stapleton, and E.R. Kandel 811
Classical Conditioning and Sensitization Share Aspects of the Same Molecular Cascade in Aplysia E.R. Kandel, T. Abrams, L Bemier, T.J. Carew, R.D. Hawkins, and J. H. Schwartz 821
Learning and Memory in Drosophila, Studied with Mutants E.O. Aceves-Piña, R. Booker, J.S. Duerr, M. S. Livingstone, W G. Quinn, R. F. Smith, P. P. Sziber, B. L. Tempel, and T.P. Tully 831
Aspects of Vision
Transducin and the Cyclic GMP Phosphodiesterase-Amplifier Proteins in Vision L. Stryer 841
Studies on the Light-transducing Pigment Bacteriorhodopsin RI. Dunn, N.R. Hackett, K. -S. Huang, S. Jones, H. G. Khorana, D -S. Lee, M.-I. Liao, K.-M. Lo, J. McCoy, S. Noguchi, R. Radhakrishnan, and U.L. RajBhandary 853
Monoclonal Antibodies That Label Discrete Cell Types in the Mammalian Nervous System C.J. Barnstable, K. Akagawa, R. Hofstein, and J.P. Horn 863
A Surface Antigen That Identifies Ocular Dominance Columns in the Visual Cortex and Laminar Features of the Lateral Geniculate Nucleus S. Hockfield, R. D. McKay, S. H. C. Hendry, and E.G. Jones 877
Summary
Neurobiology and Molecular Biology: The Second Encounter E.R. Kandel 891
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