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 XLI: Origins of Lymphocyte Diversity 1976 |
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From left: Dr. Oliver Smithies, Dr. Felix Haurowitz, Dr. Alain Bussard  SYMPOSIUM SYNOPSIS LIST OF PARTICIPANTS CONTENTS OF SYMPOSIUM VOLUME PHOTOGRAPHS PUBLISHED VOLUME  |
Origins of Lymphocyte Diversity
Symposium Volume XLI Contents
PART 1
Symposium Participants v
Foreword xv
Introduction
The Common Sense of Immunology N. K. Jerne 1
LYMPHOCYTE FUNCTION
T-cell Markers and Differentiation
Thymopoietin and Bursopoietin: Induction Signals Regulating Early Lympho- cyte Differentiation G. Goldstein, M. Scheid, E. A. Boyse, A. Brand and D. G. Gilmour 5
Normal and Neoplastic Maturation of T-lineage Lymphocytes I. L. Weissman, S. Baird, R. L. Gardner, V. E. Papaioannou and W. Raschke 9
Regulation of Cellular and Humoral Immune Responses by T-cell Subclasses H. Cantor and E. A. Boyse 23
Surface Markers and Functional Relationships of Cells Involved in Murine B-lymphocyte Differentiation L. A. Herzenberg, L. A. Herzenberg, S. J. Black, M. R. Loken, K. Okumura, W. van der Loo, B. A. Osborne, D. Hewgill, J. W. Goding, G. Gutman and N. L. Warner 33
An Unusual Kappa Immunoglobulin Antigen Present on the Membrane of T and B Lymphocytes A. B. Gottlieb, M. Engeihard, H. G. Kunkel and S. M. Fu 47
Rat Thy-i Antigens from Thymus and Brain: Their Tissue Distribution, Purifica- tion, and Chemical Composition A. F. Williams, A. N. Barclay, M. Letarte- Muirhead and R. J. Morris 51
Specialized DNA Polymerases in Lymphoid Cells D. Baltimore, A. E. Silverstone, P. C. Kung, T. A. Harrison and R. P. MeCaifrey 63
Studies on the Interactions between Viruses and Lymphocytes B. R. Bloom, A. Senik, G. Stoner, G. Ju, M. Nowakowski, S. Kano and L. Jimenez 73
Helper and Suppressor T Cells and Their Products
The Hermaphrocyte: A Suppressor-Helper T Cell R. K. Gershon, D. D. Eardley, K. F. Naidorf and W. Ptak 85
Suppressor T Cells in Tolerance to Non-self and Self Antigens A. Basten, R. Lob- lay, E. Chin, R. Callard and H. Pritchard -Briscoe 93
Tolerance: Two Pathways of Negative Immunoregulation in Contact Sensitivity to DNFB H. N. Claman, S. D. Miller and J. W. Moorhead 105
Current Concepts of the Antibody Response: Heterogeneity of Lymphoid Cells, Interactions, and Factors M. Feldmann, P. Beverley, P. Erb, S. Howie, S. Kontiainen, A. Maoz, M. Mat hies, I. McKenzie and J. Woody 113
Suppressive and Enhancing T-cell Factors as I-region Gene Products: Properties and the Subregion Assignment T. Tada, M. Taniguchi and C. S. David 119
B-cell Differentiation and Commitment
In Vitro Studies on the Generation of Lymphocyte Diversity J. J. T. Owen, R. K. Jordan, J. H. Robinson, U. Singh and H. N. A. Willcox 129
Studies of Generation of B-cell Diversity in Mouse, Man, and Chicken M. D. Cooper, J. F. Kearney, P. M. Lydyard, C. E. Grossi and A. R. Lawton 139
Ontogeny of Murine B Lymphocytes: Development of Ig Synthesis and of Reac- ivities to Mitogens and to Anti-Ig Antibodies F. Melchers, J. Andersson and R. A. Phillips 147
Development and Modulation of B Lymphocytes: Studies on Newly Formed B Cells and Their Putative Precursors in the Hemopoietic Tissues of Mice M. C. Raff 159
Induction of Immunoglobulin Synthesis in Abelson Murine Leukemia Virus- transformed Mouse Lymphoma Cells in Culture B. J. Weimann 163
The Interplay of Evolution and Environment in B-cell Diversification N. R. Klinman, N. H. Sigal, E. S. Metcalf S. K. Pierce and P. J. Gearhart 165
Synthesis of Multiple Immunoglobulin Classes by Single Lymphocytes B. Per- nis, L. Forni and A. L. Luzzati 175
Immunoglobulin Receptors on Murine B Lymphocytes E. S. Vitetta, J. Cambier, J. Forman, J. R. Kettman, D. Yuan and J. W. Uhr 185
Functional and Structural Characterization of Immunoglobulin on Murine B Lymphocytes B. M. E. Parkhouse, E. R. Abney, A. Bourgois and H. N. A. Willcox 193
Origin and Differentiation of Lymphocytes Involved in the Secretory IgA Re- sponse J. J. Cebra, P. J. Gearhart, R. Kamat, S. M. Robertson and J. Tseng 201
Mechanism of B-cell Activation and Self-Non-self Discrimination G. Möller 217
Growth and Maturation of Single Clones of Normal Murine T and B Lymphocytes In Vitro J. Andersson, A. Coutinho, F. Melchers and T. Watanabe 227
Hapten-specific B Lymphocytes: Enrichment, Cloning, Receptor Analysis, and Tolerance Induction G. J. V. Nossal, B. L. Pike, J. W. Stocker, J. E. Layton and J. W. Goding 237
Regulation of Clonal B-lymphocyte Proliferation by Anti-immunoglobulin or Anti-Ia Antibodies P. W. Kincade and P. Ralph 245
Cellular and Molecular Interactions in Control of B-cell Immunity and Tolerance E. Diener, C. Shiozawa, B. Singh and K.-C. Lee 251
Receptors
Lymphocyte Surface Immunoglobulins: Evolutionary Origins and Involvement in Activation J. J. Marchalonis, J. M. Decker, D. DeLuca, J. M. Moseley, P. Smith and G. W. Warr 261
Antigen-binding, Idiotypic Receptors from T Lymphocytes: An Analysis of Their Biochemistry, Genetics, and Use as Immunogens To Produce Specific Im- mune Tolerance H. Binz and H. Wigzell 275
On the Structure of the T-cell Receptor for Antigen U. Krawinkel, M. Cramer, C. Berek, G. Hämmerling, S. J. Black, K. Rajewsky and K. Eiehmann 285
The Immune Response to Staphylococcal Nuclease: A Probe of Cellular and Humoral Antigen-specific Receptors D. H. Sachs, J. A. Berzofsky, C. G. Fathman, D. S. Pisetsky, A. N. Schechter and R. H. Schwartz 295
Functional Characterization of Rabbit Lymphocytes Carrying Fc Receptor P.-A. Cazenave, D. Juy and C. Bona 307
Structural and Functional Heterogeneity of Fc Receptors H. M. Grey, C. L. Anderson, C. H. Heusser, B. K. Borthistle, K. B. Von Eschen and J. M. Chiller 315
Structure of the Molecular Products of the MHC
Structure of HL-A A and B Antigens Isolated from Cultured Human Lympho- cytes J. L. Strominger, D. L. Mann, P. Parham, R. Robb, T. Springer and C. Terhorst 323
Structural Studies of 132-Microglobulin-associated and Other MHC Antigens P. A. Petcrson, H. Anundi, B. Curman, L. Klareskog, S. Kvist, L. Östberg, L. Rask, L. Sandberg and K. Sege 331
Comparative Chemical Analyses and Partial Amino Acid Sequences of the Heavy Chains of HL-A Antigens E. Appella, N. Tanigaki, O. Henriksen, D. Press- man, D. F. Smith and T. Fairwell 341
Structural Differences between Parent and Variant H-2K Glycoproteins from Mouse Strains Carrying H-2 Gene Mutations S. G. Nathenson, J. L. Brown, B. M. Ewenstcin, T. Nisizawa, D. W. Sears and J. H. Freed 343
Structure of Murine Histocompatibility Antigens B. A. Cunningham, R. Hen- ning, R. J. Milner, K. Reske, J. A. Ziffer and G. M. Edelman 351
Structural Studies of H-2 and TL Alloantigens J. W. Uhr, E. S. Vitetta, J. Klein, M. D. Poulik, D. G. Klapper and J. D. Capra 363
Chemical Characterization of Products of the H-2 Complex J. Silver, J. M. Cecka, M. McMillan and L. Hood 369
Human Ia Antigens - Purification and Molecular Structure D. S nary, C. Barn- stable, W. F. Bodmer, P. Goodfellow and M. J. Crumpton 379
Chemical and Immunological Characterization of HL-A-linked B-lymphocyte Alloantigens T. A. Springer, J. F. Kaufman, L. A. Siddoway, M. Giphart, D. L. Mann, C. Terhorst and J. L. Strominger 387
The Guinea Pig MHC: Functional Significance and Structural Characterization B. D. Schwartz, A. M. Kask and E. M. Shevach 397
Partial Amino Acid Sequences of MHC Products J. Silver 405
Analysis of Lymphocyte Surface Antigen Expression by the Use of Variant Cell Lines R. Hyman and I. Trowbridge 407
PART 2
Genetics of the MHC and Associated Products
Polymorphic B-cell Determinants in Man J. J. van Rood, A. van Leeuwen, M. Jonker, A. Termijtelen and B. A. Bradley 417
Cellular Recognition of Major Histocompatibility Complex Antigens F. H. Bach, M. L. Bach, O. J. Kuperman, H. W. Sollinger and P. M. Sondel 429
Genetics and Serology of HL-A-linked Human Ia Antigens C. J. Barnstable, E. A. Jones, W. F. Bodmer, J. G. Bodmer, B. Arce-Gomez, D. Snary and M. J. Crumpton 443
Histocompatibility-2 System of Wild Mice. IV. Ia and Ir Typing of Two Wild Mouse Populations J. Klein, C. F. Merryman, P. H. Maurer, M. Hauptfeld and M. B. Gardner 457
Genetic Control of Specific Immune Responses and Immune Suppressions by I-region Genes B. Benacerraf and M. E. Doff 465
Serological and Functional Evidence for Further Subdivision of the I Regions of the H-2 Gene Complex D. C. Shreffler, C. S. David, S. E. Cullen, J. A. Fre- linger and J. E. Niederhuber 477
Functional and Genetic Analysis of Ia Antigens H. O. McDevitt, T. L. Delovitch and J. L. Press 489
Selective Expression of Separate I-region Loci in Functionally Different Lympho- cyte Subpopulations D. B. Murphy, K. Okumura, L. A. Herzenberg, L. A. Herzenberg and H. O. McDevitt 497
Role of Histocompatibility Gene Products in T-cell Cytolysis
The Concept That Surveillance of Self Is Mediated Via the Same Set of Genes That Determines Recognition of Allogenic Cells R. M. Zinkernagel and P. C. Doherty 505
F1 Hybrid Antiparental Cell-mediated Lympholysis: A Comparison with Bone Marrow Graft Rejection and with Cell-mediated Lympholysis to Alloantigens G. M. Shearer, G. Cudkowicz, A.-M. Schmitt-Verhulst,T. G. Rehn, H. Waksal and P. D. Evans 511
Cytotoxic T-cell Response to Histocompatibility Antigens: The Role of H-2 M. J. Bevan 519
Recognition of Alterations Induced by Early Vaccinia Surface Antigens and Dependence of Virus-specific Lysis on H-2 Antigen Concentration on Target Cells U. Koszinowski, H. Ertl, H. Wekerle and R. Thomssen 529
The Influence of H-2 Gene Products on Cell-mediated and Humoral Immune Re- sponses H. von Boehmer, J. Sprent and W. Haas 539
The Recognition of H-2 and Viral Antigens by Cytotoxic T Cells J. W. Schrader, R. Henning, R. J. Mimer and G. M. Edelman 547
On the Possibility of Multiple T-cell Receptors D. B. Wilson, E. Heber-Katz, J. Sprent and J. C. Howard 559
Genetic Restriction of Macrophage-Lymphocyte Interactions in Secondary Anti body Responses In Vitro C. W. Pierce, J. A. Kapp and B. Benacerraf 563
Genetic Restriction in T-lymphocyte Activation by Antigen-pulsed Peritoneal Exudate Cells W. E. Paul, E. M. Shevach, D. W. Thomas, S. F. Piekeral and A. S. Rosenthal 571
Antigen Activation of T Lymphocytes: Influence of Major Histocompatibility Complex J. F. A. P. Miller and M. A. Vadas 579
Regulatory Mechanisms in the Immune Response to Cell-surface Antigens P. Lake and N. A. Mitchison 589
The Significance of T-B Collaboration across Haplotype Barriers S. L. Swain, P. E. Trefis, H. Y.-S. Tse and R. W. Dutton 597
The Role of the Histocompatibility Gene Complex in Lymphocyte Differentiation D. H. Katz 611
Comparison of B-cell Activation Factors J. Klein 625
IMMUNOGLOBULINS
Antibody Combining Site
Model-building Studies of Antigen-binding Sites: The Hapten-binding Site of MOPC-315 E. A. Padlan, D. R. Davies, I. Pecht, D. Givol and C. Wright 627
Three-dimensional Structure and Diversity of Immunoglobulins R. J. Poliak, L. M. Amzel, B. L. Chen, Y. Y. Chiu, R. P. Phizackerley, F. Saul and X. Ysern 639
Origins of Antibody Diversity: Insights Gained from Amino Acid Sequence Studies of Elicited Antibodies E. Haber, M. N. Margolies and L. E. Cannon 647
Primary Structural Differences in Myeloma Proteins That Bind the Same Hap- tens M. Potter, S. Rudikoff, M. Vrana, D. N. Rao and E. B. Mushinski 661
Folding, Association, and Interactions of Domains in the Antibody Molecule D. Givol, J. Sharon, J. Hochman, M. Gavish, D. Inbar, I. Pecht, I.-Z. Steinberg and J. Schlessinger 667
Allotypes and Idiotypes
Rabbit Immunoglobulin Allotypes: Complexities of Their Genetics, Expression, Structural Basis, and Evolution R. G. Mage, G. O. Young-Cooper, J. Rejnek, A. A. Ansari, C. B. Alexander, E. Appella, M. Carta-Sorcini, S. Landucci-Tosi and B. M. Tosi 677
V-region Genes for Rabbit Ig Heavy Chains K. L. Knight, W. J. Horng and S. Dray 687
The Response of Rabbits to Streptococcal Hyperimmunization B. A. Fraser, A. P. Johnstone, S. M. Gordon and T. J. Kindt 689
Structure and Immunosuppression of a Cross-reactive Idiotype Associated with Anti-p-azophenylarsonate Antibodies of Strain-A Mice S.-T. Ju, F. L. Owen and A. Nisonoff 699
Idiotypes and Anti-idiotypes as Probes in Analysis of Immunoregulation H. Co- senza, A. A. Augustin and M. H. Julius 709
Immune Responses of BALB/c Mice to the Idiotype of T15 and of Other Myeloma Proteins of BALB/c Origin: Implications for an Immune Network and Anti- body Multispecificity N. Sakato, C. A. Janeway, Jr. and H. N. Eisen 719
Uniformity in a Clonal Repertoire: A Case for a Germ-line Basis of Antibody Diversity J. L. Claflin and S. Rudikoff 725
Inheritance of Antibody Specificity. IV. Control of Related Molecular Species by One VH Gene O. Mäkeäa and K. Karjalainen 735
On the Genetic Dissection of a Specific Humoral Immune Response to a(1,3) Dextran W. Geckeler, B. Blomberg, C. de Preval and M. Cohn 743
The Life Style of B Cells - Cellular Proliferation and the Invariancy of IgG B. A. Askonas and J. R. North 749
Evolution in Microcosm: The Rapid Somatic Diversification of Lymphocytes A. J. Cunningham 761
The Ontogenesis of Lymphocyte Diversity in Anuran Amphibians L. Du Pas- quier and M. R. Wabl 771
Regulation of Immunoglobulin Expression in Mouse Myeloma Cells D. H. Margulies, W. Cieplinski, B. Dharmgrongartama, M. L. Gefter, S. L. Morrison, T. Kelly and M.D. Scharif 781
Somatic Cell Genetics of Antibody-secreting Cells: Studies of Clonal Diversifica- tion and Analysis by Cell Fusion C. Milstein, K. Adetugbo, N. J. Cowan, G. Köhler, D. S. Secher and C. D. Wilde 793
The IB-peptide Marker and the Ly-3 Surface Alloantigen: Structural Studies of a Vk-region Polymorphism and a T-cell Marker Determined by Linked Genes P. D. Gottlieb and P. J. Durda 805
Generation of Diversity: 2. Structural Aspects
The Structure and Genetics of Mouse Immunoglobulins: An Analysis of NZB Myeloma Proteins and Sets of BALB/c Myeloma Proteins Binding Particular Haptens L. Hood, E. Loh, J. Hubert, P. Barstad, B. Eaton, P. Early, J. Fuhr man, N. Johnson, M. Kronenberg and J. Schilling 817
Genetic Control of Antibody Variable Regions M. Weigert and R. Riblet 837
Identical Hypervariable Regions in Light Chains of Differing Vk Subgroups J. D. Capra, D. G. Klapper, A. S. Tung and A. Nisonoff 847
Origin of Immunoglobulin Gene Diversity: The Evidence and a Restriction- Modification Model P. Leder, T. Honjo, J. Seidman and D. Swan 855
The Significance of Hybridization Kinetic Experiments for Theories of Antibody Diversity G. P. Smith 863
Somatic Changes in the Content and Context of Immunoglobulin Genes S. Ton- egawa, N. Hozumi, G. Matthyssens and R. Schuller 877
Summary
Understanding Selective Molecular Recognition G. M. Edelman 891
Symposium Participants v
Foreword xv
Introduction
The Common Sense of Immunology N. K. Jerne 1
LYMPHOCYTE FUNCTION
T-cell Markers and Differentiation
Thymopoietin and Bursopoietin: Induction Signals Regulating Early Lympho- cyte Differentiation G. Goldstein, M. Scheid, E. A. Boyse, A. Brand and D. G. Gilmour 5
Normal and Neoplastic Maturation of T-lineage Lymphocytes I. L. Weissman, S. Baird, R. L. Gardner, V. E. Papaioannou and W. Raschke 9
Regulation of Cellular and Humoral Immune Responses by T-cell Subclasses H. Cantor and E. A. Boyse 23
Surface Markers and Functional Relationships of Cells Involved in Murine B-lymphocyte Differentiation L. A. Herzenberg, L. A. Herzenberg, S. J. Black, M. R. Loken, K. Okumura, W. van der Loo, B. A. Osborne, D. Hewgill, J. W. Goding, G. Gutman and N. L. Warner 33
An Unusual Kappa Immunoglobulin Antigen Present on the Membrane of T and B Lymphocytes A. B. Gottlieb, M. Engeihard, H. G. Kunkel and S. M. Fu 47
Rat Thy-i Antigens from Thymus and Brain: Their Tissue Distribution, Purifica- tion, and Chemical Composition A. F. Williams, A. N. Barclay, M. Letarte- Muirhead and R. J. Morris 51
Specialized DNA Polymerases in Lymphoid Cells D. Baltimore, A. E. Silverstone, P. C. Kung, T. A. Harrison and R. P. MeCaifrey 63
Studies on the Interactions between Viruses and Lymphocytes B. R. Bloom, A. Senik, G. Stoner, G. Ju, M. Nowakowski, S. Kano and L. Jimenez 73
Helper and Suppressor T Cells and Their Products
The Hermaphrocyte: A Suppressor-Helper T Cell R. K. Gershon, D. D. Eardley, K. F. Naidorf and W. Ptak 85
Suppressor T Cells in Tolerance to Non-self and Self Antigens A. Basten, R. Lob- lay, E. Chin, R. Callard and H. Pritchard -Briscoe 93
Tolerance: Two Pathways of Negative Immunoregulation in Contact Sensitivity to DNFB H. N. Claman, S. D. Miller and J. W. Moorhead 105
Current Concepts of the Antibody Response: Heterogeneity of Lymphoid Cells, Interactions, and Factors M. Feldmann, P. Beverley, P. Erb, S. Howie, S. Kontiainen, A. Maoz, M. Mat hies, I. McKenzie and J. Woody 113
Suppressive and Enhancing T-cell Factors as I-region Gene Products: Properties and the Subregion Assignment T. Tada, M. Taniguchi and C. S. David 119
B-cell Differentiation and Commitment
In Vitro Studies on the Generation of Lymphocyte Diversity J. J. T. Owen, R. K. Jordan, J. H. Robinson, U. Singh and H. N. A. Willcox 129
Studies of Generation of B-cell Diversity in Mouse, Man, and Chicken M. D. Cooper, J. F. Kearney, P. M. Lydyard, C. E. Grossi and A. R. Lawton 139
Ontogeny of Murine B Lymphocytes: Development of Ig Synthesis and of Reac- ivities to Mitogens and to Anti-Ig Antibodies F. Melchers, J. Andersson and R. A. Phillips 147
Development and Modulation of B Lymphocytes: Studies on Newly Formed B Cells and Their Putative Precursors in the Hemopoietic Tissues of Mice M. C. Raff 159
Induction of Immunoglobulin Synthesis in Abelson Murine Leukemia Virus- transformed Mouse Lymphoma Cells in Culture B. J. Weimann 163
The Interplay of Evolution and Environment in B-cell Diversification N. R. Klinman, N. H. Sigal, E. S. Metcalf S. K. Pierce and P. J. Gearhart 165
Synthesis of Multiple Immunoglobulin Classes by Single Lymphocytes B. Per- nis, L. Forni and A. L. Luzzati 175
Immunoglobulin Receptors on Murine B Lymphocytes E. S. Vitetta, J. Cambier, J. Forman, J. R. Kettman, D. Yuan and J. W. Uhr 185
Functional and Structural Characterization of Immunoglobulin on Murine B Lymphocytes B. M. E. Parkhouse, E. R. Abney, A. Bourgois and H. N. A. Willcox 193
Origin and Differentiation of Lymphocytes Involved in the Secretory IgA Re- sponse J. J. Cebra, P. J. Gearhart, R. Kamat, S. M. Robertson and J. Tseng 201
Mechanism of B-cell Activation and Self-Non-self Discrimination G. Möller 217
Growth and Maturation of Single Clones of Normal Murine T and B Lymphocytes In Vitro J. Andersson, A. Coutinho, F. Melchers and T. Watanabe 227
Hapten-specific B Lymphocytes: Enrichment, Cloning, Receptor Analysis, and Tolerance Induction G. J. V. Nossal, B. L. Pike, J. W. Stocker, J. E. Layton and J. W. Goding 237
Regulation of Clonal B-lymphocyte Proliferation by Anti-immunoglobulin or Anti-Ia Antibodies P. W. Kincade and P. Ralph 245
Cellular and Molecular Interactions in Control of B-cell Immunity and Tolerance E. Diener, C. Shiozawa, B. Singh and K.-C. Lee 251
Receptors
Lymphocyte Surface Immunoglobulins: Evolutionary Origins and Involvement in Activation J. J. Marchalonis, J. M. Decker, D. DeLuca, J. M. Moseley, P. Smith and G. W. Warr 261
Antigen-binding, Idiotypic Receptors from T Lymphocytes: An Analysis of Their Biochemistry, Genetics, and Use as Immunogens To Produce Specific Im- mune Tolerance H. Binz and H. Wigzell 275
On the Structure of the T-cell Receptor for Antigen U. Krawinkel, M. Cramer, C. Berek, G. Hämmerling, S. J. Black, K. Rajewsky and K. Eiehmann 285
The Immune Response to Staphylococcal Nuclease: A Probe of Cellular and Humoral Antigen-specific Receptors D. H. Sachs, J. A. Berzofsky, C. G. Fathman, D. S. Pisetsky, A. N. Schechter and R. H. Schwartz 295
Functional Characterization of Rabbit Lymphocytes Carrying Fc Receptor P.-A. Cazenave, D. Juy and C. Bona 307
Structural and Functional Heterogeneity of Fc Receptors H. M. Grey, C. L. Anderson, C. H. Heusser, B. K. Borthistle, K. B. Von Eschen and J. M. Chiller 315
Structure of the Molecular Products of the MHC
Structure of HL-A A and B Antigens Isolated from Cultured Human Lympho- cytes J. L. Strominger, D. L. Mann, P. Parham, R. Robb, T. Springer and C. Terhorst 323
Structural Studies of 132-Microglobulin-associated and Other MHC Antigens P. A. Petcrson, H. Anundi, B. Curman, L. Klareskog, S. Kvist, L. Östberg, L. Rask, L. Sandberg and K. Sege 331
Comparative Chemical Analyses and Partial Amino Acid Sequences of the Heavy Chains of HL-A Antigens E. Appella, N. Tanigaki, O. Henriksen, D. Press- man, D. F. Smith and T. Fairwell 341
Structural Differences between Parent and Variant H-2K Glycoproteins from Mouse Strains Carrying H-2 Gene Mutations S. G. Nathenson, J. L. Brown, B. M. Ewenstcin, T. Nisizawa, D. W. Sears and J. H. Freed 343
Structure of Murine Histocompatibility Antigens B. A. Cunningham, R. Hen- ning, R. J. Milner, K. Reske, J. A. Ziffer and G. M. Edelman 351
Structural Studies of H-2 and TL Alloantigens J. W. Uhr, E. S. Vitetta, J. Klein, M. D. Poulik, D. G. Klapper and J. D. Capra 363
Chemical Characterization of Products of the H-2 Complex J. Silver, J. M. Cecka, M. McMillan and L. Hood 369
Human Ia Antigens - Purification and Molecular Structure D. S nary, C. Barn- stable, W. F. Bodmer, P. Goodfellow and M. J. Crumpton 379
Chemical and Immunological Characterization of HL-A-linked B-lymphocyte Alloantigens T. A. Springer, J. F. Kaufman, L. A. Siddoway, M. Giphart, D. L. Mann, C. Terhorst and J. L. Strominger 387
The Guinea Pig MHC: Functional Significance and Structural Characterization B. D. Schwartz, A. M. Kask and E. M. Shevach 397
Partial Amino Acid Sequences of MHC Products J. Silver 405
Analysis of Lymphocyte Surface Antigen Expression by the Use of Variant Cell Lines R. Hyman and I. Trowbridge 407
PART 2
Genetics of the MHC and Associated Products
Polymorphic B-cell Determinants in Man J. J. van Rood, A. van Leeuwen, M. Jonker, A. Termijtelen and B. A. Bradley 417
Cellular Recognition of Major Histocompatibility Complex Antigens F. H. Bach, M. L. Bach, O. J. Kuperman, H. W. Sollinger and P. M. Sondel 429
Genetics and Serology of HL-A-linked Human Ia Antigens C. J. Barnstable, E. A. Jones, W. F. Bodmer, J. G. Bodmer, B. Arce-Gomez, D. Snary and M. J. Crumpton 443
Histocompatibility-2 System of Wild Mice. IV. Ia and Ir Typing of Two Wild Mouse Populations J. Klein, C. F. Merryman, P. H. Maurer, M. Hauptfeld and M. B. Gardner 457
Genetic Control of Specific Immune Responses and Immune Suppressions by I-region Genes B. Benacerraf and M. E. Doff 465
Serological and Functional Evidence for Further Subdivision of the I Regions of the H-2 Gene Complex D. C. Shreffler, C. S. David, S. E. Cullen, J. A. Fre- linger and J. E. Niederhuber 477
Functional and Genetic Analysis of Ia Antigens H. O. McDevitt, T. L. Delovitch and J. L. Press 489
Selective Expression of Separate I-region Loci in Functionally Different Lympho- cyte Subpopulations D. B. Murphy, K. Okumura, L. A. Herzenberg, L. A. Herzenberg and H. O. McDevitt 497
Role of Histocompatibility Gene Products in T-cell Cytolysis
The Concept That Surveillance of Self Is Mediated Via the Same Set of Genes That Determines Recognition of Allogenic Cells R. M. Zinkernagel and P. C. Doherty 505
F1 Hybrid Antiparental Cell-mediated Lympholysis: A Comparison with Bone Marrow Graft Rejection and with Cell-mediated Lympholysis to Alloantigens G. M. Shearer, G. Cudkowicz, A.-M. Schmitt-Verhulst,T. G. Rehn, H. Waksal and P. D. Evans 511
Cytotoxic T-cell Response to Histocompatibility Antigens: The Role of H-2 M. J. Bevan 519
Recognition of Alterations Induced by Early Vaccinia Surface Antigens and Dependence of Virus-specific Lysis on H-2 Antigen Concentration on Target Cells U. Koszinowski, H. Ertl, H. Wekerle and R. Thomssen 529
The Influence of H-2 Gene Products on Cell-mediated and Humoral Immune Re- sponses H. von Boehmer, J. Sprent and W. Haas 539
The Recognition of H-2 and Viral Antigens by Cytotoxic T Cells J. W. Schrader, R. Henning, R. J. Mimer and G. M. Edelman 547
On the Possibility of Multiple T-cell Receptors D. B. Wilson, E. Heber-Katz, J. Sprent and J. C. Howard 559
Genetic Restriction of Macrophage-Lymphocyte Interactions in Secondary Anti body Responses In Vitro C. W. Pierce, J. A. Kapp and B. Benacerraf 563
Genetic Restriction in T-lymphocyte Activation by Antigen-pulsed Peritoneal Exudate Cells W. E. Paul, E. M. Shevach, D. W. Thomas, S. F. Piekeral and A. S. Rosenthal 571
Antigen Activation of T Lymphocytes: Influence of Major Histocompatibility Complex J. F. A. P. Miller and M. A. Vadas 579
Regulatory Mechanisms in the Immune Response to Cell-surface Antigens P. Lake and N. A. Mitchison 589
The Significance of T-B Collaboration across Haplotype Barriers S. L. Swain, P. E. Trefis, H. Y.-S. Tse and R. W. Dutton 597
The Role of the Histocompatibility Gene Complex in Lymphocyte Differentiation D. H. Katz 611
Comparison of B-cell Activation Factors J. Klein 625
IMMUNOGLOBULINS
Antibody Combining Site
Model-building Studies of Antigen-binding Sites: The Hapten-binding Site of MOPC-315 E. A. Padlan, D. R. Davies, I. Pecht, D. Givol and C. Wright 627
Three-dimensional Structure and Diversity of Immunoglobulins R. J. Poliak, L. M. Amzel, B. L. Chen, Y. Y. Chiu, R. P. Phizackerley, F. Saul and X. Ysern 639
Origins of Antibody Diversity: Insights Gained from Amino Acid Sequence Studies of Elicited Antibodies E. Haber, M. N. Margolies and L. E. Cannon 647
Primary Structural Differences in Myeloma Proteins That Bind the Same Hap- tens M. Potter, S. Rudikoff, M. Vrana, D. N. Rao and E. B. Mushinski 661
Folding, Association, and Interactions of Domains in the Antibody Molecule D. Givol, J. Sharon, J. Hochman, M. Gavish, D. Inbar, I. Pecht, I.-Z. Steinberg and J. Schlessinger 667
Allotypes and Idiotypes
Rabbit Immunoglobulin Allotypes: Complexities of Their Genetics, Expression, Structural Basis, and Evolution R. G. Mage, G. O. Young-Cooper, J. Rejnek, A. A. Ansari, C. B. Alexander, E. Appella, M. Carta-Sorcini, S. Landucci-Tosi and B. M. Tosi 677
V-region Genes for Rabbit Ig Heavy Chains K. L. Knight, W. J. Horng and S. Dray 687
The Response of Rabbits to Streptococcal Hyperimmunization B. A. Fraser, A. P. Johnstone, S. M. Gordon and T. J. Kindt 689
Structure and Immunosuppression of a Cross-reactive Idiotype Associated with Anti-p-azophenylarsonate Antibodies of Strain-A Mice S.-T. Ju, F. L. Owen and A. Nisonoff 699
Idiotypes and Anti-idiotypes as Probes in Analysis of Immunoregulation H. Co- senza, A. A. Augustin and M. H. Julius 709
Immune Responses of BALB/c Mice to the Idiotype of T15 and of Other Myeloma Proteins of BALB/c Origin: Implications for an Immune Network and Anti- body Multispecificity N. Sakato, C. A. Janeway, Jr. and H. N. Eisen 719
Uniformity in a Clonal Repertoire: A Case for a Germ-line Basis of Antibody Diversity J. L. Claflin and S. Rudikoff 725
Inheritance of Antibody Specificity. IV. Control of Related Molecular Species by One VH Gene O. Mäkeäa and K. Karjalainen 735
On the Genetic Dissection of a Specific Humoral Immune Response to a(1,3) Dextran W. Geckeler, B. Blomberg, C. de Preval and M. Cohn 743
The Life Style of B Cells - Cellular Proliferation and the Invariancy of IgG B. A. Askonas and J. R. North 749
Evolution in Microcosm: The Rapid Somatic Diversification of Lymphocytes A. J. Cunningham 761
The Ontogenesis of Lymphocyte Diversity in Anuran Amphibians L. Du Pas- quier and M. R. Wabl 771
Regulation of Immunoglobulin Expression in Mouse Myeloma Cells D. H. Margulies, W. Cieplinski, B. Dharmgrongartama, M. L. Gefter, S. L. Morrison, T. Kelly and M.D. Scharif 781
Somatic Cell Genetics of Antibody-secreting Cells: Studies of Clonal Diversifica- tion and Analysis by Cell Fusion C. Milstein, K. Adetugbo, N. J. Cowan, G. Köhler, D. S. Secher and C. D. Wilde 793
The IB-peptide Marker and the Ly-3 Surface Alloantigen: Structural Studies of a Vk-region Polymorphism and a T-cell Marker Determined by Linked Genes P. D. Gottlieb and P. J. Durda 805
Generation of Diversity: 2. Structural Aspects
The Structure and Genetics of Mouse Immunoglobulins: An Analysis of NZB Myeloma Proteins and Sets of BALB/c Myeloma Proteins Binding Particular Haptens L. Hood, E. Loh, J. Hubert, P. Barstad, B. Eaton, P. Early, J. Fuhr man, N. Johnson, M. Kronenberg and J. Schilling 817
Genetic Control of Antibody Variable Regions M. Weigert and R. Riblet 837
Identical Hypervariable Regions in Light Chains of Differing Vk Subgroups J. D. Capra, D. G. Klapper, A. S. Tung and A. Nisonoff 847
Origin of Immunoglobulin Gene Diversity: The Evidence and a Restriction- Modification Model P. Leder, T. Honjo, J. Seidman and D. Swan 855
The Significance of Hybridization Kinetic Experiments for Theories of Antibody Diversity G. P. Smith 863
Somatic Changes in the Content and Context of Immunoglobulin Genes S. Ton- egawa, N. Hozumi, G. Matthyssens and R. Schuller 877
Summary
Understanding Selective Molecular Recognition G. M. Edelman 891
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