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 XXXII: Antibodies 1967 |
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From left: Dr. G.J.V. Nossal, Mrs. Melvin Cohn, Dr. Melvin Cohn  SYMPOSIUM SYNOPSIS LIST OF PARTICIPANTS CONTENTS OF SYMPOSIUM VOLUME PHOTOGRAPHS PUBLISHED VOLUME  |
Antibodies
Symposium Volume XXXII Contents
Foreword v
List of Previous Volumes vi
Photographs of Some Symposium Participants vii
List of Those Attending the Symposium ix
INTRODUCTION
SIR MACFARLANE BURNET. The Impact of Ideas on Immunology 1
STRUCTURE OF ANTIBODIES
PUTNAM, F. W., K. TITANI, M. WIKLER and T. SHINODA: Structure and evolution of kappa and lambda light chains 9
MILSTEIN, C. B., B. FRANGIONI, and J. R. L. PINK: Studies on the variability of immunoglobulin sequence 31
APPELLA, E. and R. M. PERHAM: Structure of immunoglobulin light chains 37
PRESS, E. M. and P. J. PIGGOT: The chemical structure of the heavy chain of human immunoglobulin G 45
WAXDAL, M. J., W. H. KONIGSBERG and G. M. EDELMAN: The structure of a human gamma G immunoglobulin 53
CEBRA, J. J.: Common peptides comprising the N-terminal half of heavy chain from rabbit IgG and specific antibodies 65
EISEN, H. N., J. R. LITTLE, C. K. OSTERLAND and E. S. SIMMS: A myeloma protein with antibody activity 75
STONE, M. J. and H. METZGER: The valence of a Waldenstrom macroglobulin antibody and further thoughts on the significance of paraprotein antibodies 83 NIZONOFF, A., S. ZAPPACOSTA and R. JUREZIZ: Properties of crystallized rabbit anti-P azobenzoate antibody 89
POLJAK R. J., D. J. GOLDSTEIN, R. L. HUMPHREY and H. M. DINTZIS: Crystallo- graphic studies of rabbit and human Fc fragments 95
SINGER, S. J., L. I. SLOBIN, N. O. THORPE and J. W. FENTON, II: On the structure of antibody active sites 99
WOFSY, L. and D. C. PARKER: Comparative studies of antibody active sites 111
YOO, T. J., O. A. ROHOLT, and D. PRESSMAN: Hapten binding activity in isolated light polypeptide chains from rabbit antibody 117
KOSHLAND, M. E.: Location of specificity and allotypic amino acid residues in antibody Fd fragments 119
HAMERS, R. and C. HAMERS-CASTERMAN: Evidence for the presence of the Fc allotypic marker As8 and the Fd allotypic marker Asi in the same molecules of rabbit IgG 129
EVOLUTION AND GENETICS OF ANTIBODIES
HOOD, L., W. R. GRAY, B. G. SANDERS and W. J. DREYER: Light chain evolution 133
BAGLIONI, C., D. CIOLI, G. GORINI, A. RUFFILLI and L. ALESCIO-ZONTA: Studies on fragments of light chains of human immunoglobulins: Genetic and biochemical implications 147
SMITHIES, O.: The genetic basis of antibody variability 161
CRICK, F. H. C., L. HOOD, O. SMITHIES, W. J. DREYER, C. MILSTEIN, B. PAPERMASTER, N. A. MITCHISON, J. J. CEBRA, D. W. TALMAGE, C. BAGLIONI, G. EDELMAN, N. JERNE: General discussion on theories of antibody variability 169
NATVIG, J. B., H. G. KUNKEL and S. P. LITWIN: Genetic markers of the heavy chain subgroups of human gamma G globulin 178
HERZENBERG, L. A., J. D. MINNA and L. A. HERZENBERG: The chromosome region for immunoglobulin heavy chains in the mouse: allelic electrophoretic mobility differences and allotype suppression 181
POTTER, M. and R. LIEBERMAN: Genetic studies of immunoglobulins in mice 187
MAGE, R. G.: Quantitative studies on the regulation of expression of genes for immunoglobulin allotypes in heterozygous rabbits 203
SYNTHESIS OF ANTIBODIES
COHN, M.: Natural history of the mycloma 211
ASKONAS, B. A. and A. R. WILLIAMSON: Biosynthesis and assembly of immuno- globulin G 223
FLEISCHMAN, J. B.: Synthesis of the rabbit gamma G heavy chain 233
SCHARFF, M. D., A. L. SHAPIRO and B. GINSBERG: The synthesis, assembly and secretion of gamma globulin polypeptide chains by cells of a mouse plasma cell tumor 235
GREENBERG, L. J. and J. W. UHR: DNA-RNA hybridization studies of immuno- globulin synthesizing tumors in mice 243
LENNOX, E. S., P. M. KNOPE, A. J. MUNRO and R. M. E. PARKHOUSE: A search for biosynthetic subunits of light and heavy chains of immunoglobulins 249
MELCHERS, F. and P. M. KNOPF: Biosynthesis of the carbohydrate portion of immunoglobulin chains: Possible relation to secretions 255
MOROZ, C. and J. W. UHR: Synthesis of the carbohydrate moiety of gamma globulin 263
KERN, M. and R. M. SWENSON: Biochemical studies of the intracellular events involved in the secretion of gamma globulin 265
MACH, B., H. KOBLET and D. GROSS: Biosynthesis of immunoglobulin in a cell- free system 269
RALPH, P., M. BECKER and A. RICH: Immunoglobulin synthesis in a cell-free system 277
FAHEY, J. L. and I. FINEGOLD: Synthesis of immunoglobulins in human lymphoid cell lines 283
REISFELD, R. A.: Heterogeneity of rabbit light-poly peptide chains 291
HABER, E., F. F. RICHARDS, J. SPRAGG, K. F. AUSTEN, M. VALLOTTON and L. B. PAGE: Modifications in the heterogeneity of the antibody response 299
DUBISKI, S.: Synthesis of allotypically defined immunoglobulins in rabbits 311
CHOU, C. T., B. CINADER, and S. DUBISKI: Quantitative studies of antibody production by plaque-forming cells 317
PERNIS, B.: Relationships between the heterogeneity of immunoglobulins and the differentiation of plasma cells 333
FISHMAN, M. and F. L. ADLER: The role of macrophage-~RNA in the immune response 343
COHEN, E. P. and K. RASKA: Antigen-unique species of RNA in peritoneal cells of mice which do not adhere to glass 349
DREYER, W. J., W. R. GRAY, and L. HOOD: The genetic, molecular, and cellular basis of antibody formation: some facts and a unifying hypothesis 353
DIFFERENTIATION AND CELLULAR EVENTS
NOSSAL, G. J. V., K. D. SHORTMAN, J. F. A. P. MILLER, G. F. MITCHELL, and J. S. HASKILL: The target cell in the induction of immunity and tolerance 369
ADA, G. L., C. R. PARRISH, G. J. V. NOSSAL, and A. ABBOT: The tissue localiz- ation, immunogenic, and tolerance-inducing properties of antigens and antigen-fragments 381
ELLIS, S. T., J. L. GOWANS and J. C. HOWARD: Cellular events during the formation of antibody 395
DUTTON, R. W. and R. I. MISHELL: Cellular events in the immune response. The in vitro response of normal spleen cells to erythrocyte antigens 407
FELDMAN, M. and R. GALLILY: Cell interactions in the induction of antibody formation 415
MÄKELÄ, O: The Specificities of antibodies produced by single cells 423
MITCHISON, N. A.: Antigen recognition responsible for the induction in vitro of the secondary response 431
GELL, P. G. H.: Restrictions on antibody production by single cells 441
PAPERMASTER, B. W.: The clonal differentiation of antibody-producing cells 447
TILL, J. E., E. A. MCCULLOCH, R. A. PHILLIPS and L. SIMINOVITCH: Analysis of differentiating clones derived from marrow 461
BUSSARD, A. E.: Primary antibody response induced in vitro among cells from normal animals 465
LITT, M.: Studies of the latent period. I. Primary antibody in guinea pig lymph nodes 7½ minutes after introduction of chicken erythrocytes 477
ŠTERZL, J.: Factors determining the differentiation pathways of immuno- competent cells 493
WIGZELL, T.: Studies on the regulation of antibody synthesis 507
SIMONSEN, M.: The clonal selection hypothesis evaluated by grafted cells reacting against their hosts 517
FAZEKAS, S. de ST. GROTH: Cross recognition and cross reactivity 525
SELA, M., B. SCHECHTER, I. SCHECHTER, and F. BOREK: Antibodies to sequential and conformational determinants 537
RAJEWSKY, K. and E. ROTTLANDER: Tolerance specificity and the immune response to lactic dehydrogenase isoenzymes 547
WEIGLE, W. O. and E. S. GOLUB: Kinetics of the establishment of immunological unresponsiveness to serum protein antigens 555
HAUROWITZ, F.: Evolution of selective and instructive theories of antibody formation 559
BENACERRAF, B., I. GREEN, and W. E. PAUL: The immune response of guinea pigs to hapten-poly-L-lysine conjugates as an example of the genetic control of the recognition of antigenicity 569
SJÖQUIST, J., A. FORSGREN, G. T. GUSTAFSON, and G. STÅLENHEIM: Biological importance of the Fc-region of gamma globulins 577
METCALF, D.: Relation of the thymus to the formation of the immunologically reactive cells 583
SUMMARY
JERNE, N. K.: Waiting for the End 591
List of Previous Volumes vi
Photographs of Some Symposium Participants vii
List of Those Attending the Symposium ix
INTRODUCTION
SIR MACFARLANE BURNET. The Impact of Ideas on Immunology 1
STRUCTURE OF ANTIBODIES
PUTNAM, F. W., K. TITANI, M. WIKLER and T. SHINODA: Structure and evolution of kappa and lambda light chains 9
MILSTEIN, C. B., B. FRANGIONI, and J. R. L. PINK: Studies on the variability of immunoglobulin sequence 31
APPELLA, E. and R. M. PERHAM: Structure of immunoglobulin light chains 37
PRESS, E. M. and P. J. PIGGOT: The chemical structure of the heavy chain of human immunoglobulin G 45
WAXDAL, M. J., W. H. KONIGSBERG and G. M. EDELMAN: The structure of a human gamma G immunoglobulin 53
CEBRA, J. J.: Common peptides comprising the N-terminal half of heavy chain from rabbit IgG and specific antibodies 65
EISEN, H. N., J. R. LITTLE, C. K. OSTERLAND and E. S. SIMMS: A myeloma protein with antibody activity 75
STONE, M. J. and H. METZGER: The valence of a Waldenstrom macroglobulin antibody and further thoughts on the significance of paraprotein antibodies 83 NIZONOFF, A., S. ZAPPACOSTA and R. JUREZIZ: Properties of crystallized rabbit anti-P azobenzoate antibody 89
POLJAK R. J., D. J. GOLDSTEIN, R. L. HUMPHREY and H. M. DINTZIS: Crystallo- graphic studies of rabbit and human Fc fragments 95
SINGER, S. J., L. I. SLOBIN, N. O. THORPE and J. W. FENTON, II: On the structure of antibody active sites 99
WOFSY, L. and D. C. PARKER: Comparative studies of antibody active sites 111
YOO, T. J., O. A. ROHOLT, and D. PRESSMAN: Hapten binding activity in isolated light polypeptide chains from rabbit antibody 117
KOSHLAND, M. E.: Location of specificity and allotypic amino acid residues in antibody Fd fragments 119
HAMERS, R. and C. HAMERS-CASTERMAN: Evidence for the presence of the Fc allotypic marker As8 and the Fd allotypic marker Asi in the same molecules of rabbit IgG 129
EVOLUTION AND GENETICS OF ANTIBODIES
HOOD, L., W. R. GRAY, B. G. SANDERS and W. J. DREYER: Light chain evolution 133
BAGLIONI, C., D. CIOLI, G. GORINI, A. RUFFILLI and L. ALESCIO-ZONTA: Studies on fragments of light chains of human immunoglobulins: Genetic and biochemical implications 147
SMITHIES, O.: The genetic basis of antibody variability 161
CRICK, F. H. C., L. HOOD, O. SMITHIES, W. J. DREYER, C. MILSTEIN, B. PAPERMASTER, N. A. MITCHISON, J. J. CEBRA, D. W. TALMAGE, C. BAGLIONI, G. EDELMAN, N. JERNE: General discussion on theories of antibody variability 169
NATVIG, J. B., H. G. KUNKEL and S. P. LITWIN: Genetic markers of the heavy chain subgroups of human gamma G globulin 178
HERZENBERG, L. A., J. D. MINNA and L. A. HERZENBERG: The chromosome region for immunoglobulin heavy chains in the mouse: allelic electrophoretic mobility differences and allotype suppression 181
POTTER, M. and R. LIEBERMAN: Genetic studies of immunoglobulins in mice 187
MAGE, R. G.: Quantitative studies on the regulation of expression of genes for immunoglobulin allotypes in heterozygous rabbits 203
SYNTHESIS OF ANTIBODIES
COHN, M.: Natural history of the mycloma 211
ASKONAS, B. A. and A. R. WILLIAMSON: Biosynthesis and assembly of immuno- globulin G 223
FLEISCHMAN, J. B.: Synthesis of the rabbit gamma G heavy chain 233
SCHARFF, M. D., A. L. SHAPIRO and B. GINSBERG: The synthesis, assembly and secretion of gamma globulin polypeptide chains by cells of a mouse plasma cell tumor 235
GREENBERG, L. J. and J. W. UHR: DNA-RNA hybridization studies of immuno- globulin synthesizing tumors in mice 243
LENNOX, E. S., P. M. KNOPE, A. J. MUNRO and R. M. E. PARKHOUSE: A search for biosynthetic subunits of light and heavy chains of immunoglobulins 249
MELCHERS, F. and P. M. KNOPF: Biosynthesis of the carbohydrate portion of immunoglobulin chains: Possible relation to secretions 255
MOROZ, C. and J. W. UHR: Synthesis of the carbohydrate moiety of gamma globulin 263
KERN, M. and R. M. SWENSON: Biochemical studies of the intracellular events involved in the secretion of gamma globulin 265
MACH, B., H. KOBLET and D. GROSS: Biosynthesis of immunoglobulin in a cell- free system 269
RALPH, P., M. BECKER and A. RICH: Immunoglobulin synthesis in a cell-free system 277
FAHEY, J. L. and I. FINEGOLD: Synthesis of immunoglobulins in human lymphoid cell lines 283
REISFELD, R. A.: Heterogeneity of rabbit light-poly peptide chains 291
HABER, E., F. F. RICHARDS, J. SPRAGG, K. F. AUSTEN, M. VALLOTTON and L. B. PAGE: Modifications in the heterogeneity of the antibody response 299
DUBISKI, S.: Synthesis of allotypically defined immunoglobulins in rabbits 311
CHOU, C. T., B. CINADER, and S. DUBISKI: Quantitative studies of antibody production by plaque-forming cells 317
PERNIS, B.: Relationships between the heterogeneity of immunoglobulins and the differentiation of plasma cells 333
FISHMAN, M. and F. L. ADLER: The role of macrophage-~RNA in the immune response 343
COHEN, E. P. and K. RASKA: Antigen-unique species of RNA in peritoneal cells of mice which do not adhere to glass 349
DREYER, W. J., W. R. GRAY, and L. HOOD: The genetic, molecular, and cellular basis of antibody formation: some facts and a unifying hypothesis 353
DIFFERENTIATION AND CELLULAR EVENTS
NOSSAL, G. J. V., K. D. SHORTMAN, J. F. A. P. MILLER, G. F. MITCHELL, and J. S. HASKILL: The target cell in the induction of immunity and tolerance 369
ADA, G. L., C. R. PARRISH, G. J. V. NOSSAL, and A. ABBOT: The tissue localiz- ation, immunogenic, and tolerance-inducing properties of antigens and antigen-fragments 381
ELLIS, S. T., J. L. GOWANS and J. C. HOWARD: Cellular events during the formation of antibody 395
DUTTON, R. W. and R. I. MISHELL: Cellular events in the immune response. The in vitro response of normal spleen cells to erythrocyte antigens 407
FELDMAN, M. and R. GALLILY: Cell interactions in the induction of antibody formation 415
MÄKELÄ, O: The Specificities of antibodies produced by single cells 423
MITCHISON, N. A.: Antigen recognition responsible for the induction in vitro of the secondary response 431
GELL, P. G. H.: Restrictions on antibody production by single cells 441
PAPERMASTER, B. W.: The clonal differentiation of antibody-producing cells 447
TILL, J. E., E. A. MCCULLOCH, R. A. PHILLIPS and L. SIMINOVITCH: Analysis of differentiating clones derived from marrow 461
BUSSARD, A. E.: Primary antibody response induced in vitro among cells from normal animals 465
LITT, M.: Studies of the latent period. I. Primary antibody in guinea pig lymph nodes 7½ minutes after introduction of chicken erythrocytes 477
ŠTERZL, J.: Factors determining the differentiation pathways of immuno- competent cells 493
WIGZELL, T.: Studies on the regulation of antibody synthesis 507
SIMONSEN, M.: The clonal selection hypothesis evaluated by grafted cells reacting against their hosts 517
FAZEKAS, S. de ST. GROTH: Cross recognition and cross reactivity 525
SELA, M., B. SCHECHTER, I. SCHECHTER, and F. BOREK: Antibodies to sequential and conformational determinants 537
RAJEWSKY, K. and E. ROTTLANDER: Tolerance specificity and the immune response to lactic dehydrogenase isoenzymes 547
WEIGLE, W. O. and E. S. GOLUB: Kinetics of the establishment of immunological unresponsiveness to serum protein antigens 555
HAUROWITZ, F.: Evolution of selective and instructive theories of antibody formation 559
BENACERRAF, B., I. GREEN, and W. E. PAUL: The immune response of guinea pigs to hapten-poly-L-lysine conjugates as an example of the genetic control of the recognition of antigenicity 569
SJÖQUIST, J., A. FORSGREN, G. T. GUSTAFSON, and G. STÅLENHEIM: Biological importance of the Fc-region of gamma globulins 577
METCALF, D.: Relation of the thymus to the formation of the immunologically reactive cells 583
SUMMARY
JERNE, N. K.: Waiting for the End 591
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