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 XXVI: Cellular Regulatory Mechanisms 1961 |
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From left: Dr. T.F. Anderson,Dr. Syndney Brenner, Dr. James Watson, Dr. Francois Jacob, Dr. Frank Stahl, Dr. Alfred Hershey (back to camera)  SYMPOSIUM SYNOPSIS LIST OF PARTICIPANTS CONTENTS OF SYMPOSIUM VOLUME PHOTOGRAPHS PUBLISHED VOLUME  |
Cellular Regulatory Mechanisms
Symposium Volume XXVI Contents
Foreword v
List of Previous Volumes vi
Photographs of Some Participants vii
List of Those Attending the Symposium ix
OPENING ADDRESS
DAVIS, B. D. The, Teleonomic Significance of Biosynthetic Control Mechanisms 1
THE ROLE OF DNA IN PROTEIN SYNTHESIS
YANOFSKY, C., D. R. HELINSKI, AND B. D. MALING. The Effects of Mutation on the Composition and Properties of the A Protein of Escherichia coli Tryptophan Synthetase 11
STREISINGER, G., F. MUKAI, W. J. DREYER, B. MILLER, AND S. HORIUCHI. Mutations Affecting the Lysozyme of Phage T4 25
SIGNER, E. R., A. TORRIANI, AND C. LEVINTHAL. Gene Expression in Intergeneric Merozygotes 31
SUEOKA, N. Compositional Correlation between Deoxyribonucleic Acid and Protein 35
THE CONTROL OF NUCLEIC ACID SYNTHESIS
MAALĂE, O. The Control of Normal DNA Replication in Bacteria 45
SCHAECHTER, M. Patterns of Cellular Control during Unbalanced Growth 53
NEIDHARDT, F. C., AND D. G. FRAENKEL. Metabolic Regulation of RNA Synthesis in' Bacteria 63
THE ROLE OF DNA IN RNA SYNTHESIS
SPIEGELMAN, S. The Relation of Informational RNA to DNA 75
HURWITZ, J., J. J. FURTH, M. ANDERS, P. J. ORTIZ, AND J. T. AUGUST. The Enzymatic Incorporation of Ribonucleotides into RNA and the Role of DNA 91
THE ROLE OF RNA IN PROTEIN SYNTHESIS
BRENNER, S. RNA, Ribosomes, and Protein Synthesis 101
GROS, F., W. GILBERT, H. H. HIATT, G. ATTARDI, P. F. SPAHR, AND J. D. WATSON. Molecular and Biological Characterization of Messenger RNA 111
NOVELLI, G. D., T. KAMEYAMA, AND J. M. EISENSTADT. The Nature of the System Catalyzing the Synthesis of Induced b-Galactosidase 133
NISMAN, B., R. COHEN, A. KAYSER, H. FUKUHARA, J. DEMAILLY, C. GENIN, AND D. GIRON. Specific Protein Synthesis in Subcellular Systems of Escherichia coli 145
HOAGLAND, M. Some Factors Influencing Protein Synthetic Activity in a Cell-Free Mammalian System 153
PLESNER, P. Changes in Ribosome Structure and Function during Synchronized Cell Division 159
REGULATION OF ENZYME SYNTHESIS
VOGEL, H. J. Aspects of Repression in the Regulation of Enzyme Synthesis: Pathway-wide Control and Enzyme-specific Response 163
GORINI, L., W. GUNDERSEN, AND M. BURGER. Genetics of Regulation of Enzyme Synthesis in the Arginine Biosynthetic Pathway of Escherichia coli 173
MAAS, W. K. Studies on Repression of Arginine Biosynthesis in Escherichia coli 183
JACOB, F. AND J. MONOD. On the Regulation of Gene Activity 193
BUTTIN, G. Some Aspects of Regulation in the Synthesis of the Enzymes Governing Galactose Metabolism 213
YARMOLINSKY, M. B., E. JORDAN, AND H. WIESMEYER. Regulatory Mechanisms in the Synthesis of Enzymes of Galactose Metabolism. I. Coordinate Repression and De-Repression of the "Galactose Sequence." 217
KALCKAR, H. AND T. A. SUNDARARAJAN. Regulatory Mechanisms in the Synthesis of Enzymes of Galactose Metabolism. II. Genetic Defects in Galactokinase Activity and Their Relations to its Functions 227
HOROWITZ, N. H., M. FLING, H. MACLEOD, AND Y. WATANABE. Structural and Regulative Genes Controlling Tyrosinase Synthesis in Neurospora 233
NOVICK, A. AND a'. HORIUCHI. Hyper-Production of b-Galactosidase by Escherichia coli Bacteria 239 HORIUCHI, T. AND A. NOVICK. A Thermolabile Repression System 247
MAGASANIK, B. Catabolite Repression 249
KORNBERG, H. L. Selective Utilization of Metabolic Routes by Escherichia coli 257
ENGLESBERG, E., J. A. WATSON, AND P. A. HOFFEE. The Glucose Effect and the Relationship between Glucose Permease, Acid Phosphatase, and Glucose Resistance 261
CONTROL OF ENZYME ACTIVITY: COMPETITION BETWEEN ENZYMES
HOLZER, H. Regulation of Carbohydrate Metabolism by Enzyme Competition 277
CHANCE, B. Control Characteristics of Enzyme Systems 289
CONTROL OF ENZYME ACTIVITY: FEEDBACK CONTROL
UMBARGER, H. E. Feedback Control by Endproduct Inhibition 301
CHANGEUX, J. The Feedback Control Mechanism of Biosynthetic L-Threonine Deaminase by L-Isoleucine 313
STADTMAN, E. R., G. N. COHEN, G. LE BRAS, AND H. DE ROBICHON-SZULMAJSTER. Selective Feedback Inhibition and Repression of Two Aspartokinases in the Metabolism of Escherichia coli 319
MOYED, H. S. Interference with Feedback Control of Enzyme Activity 323
CONTROL OF ENZYME FORMATION AND ACTIVITY IN ANIMAL SYSTEMS
TOMKINS, G. M. AND K. L. YIELDING. Regulation of the Enzymic Activity of Glutamic Dehydrogenase Mediated by Changes in its Structure 331
MARKS, P. A. Glucose-6P Dehydrogenase Stability, Activation, and Inactivation 343
RALL, T. W. AND E. W. SUTHERLAND. The Regulatory Role of Adenosine-3', 5'-phosphate 347
POTTER, V. R. AND T. ONO. Enzyme Patterns in Rat Liver and Morris Hepatoma 5123 During Metabolic Transitions 355
SCHIMKE, R. T. Studies on Adaptation of Urea Cycle Enzymes in the Rat 363
HIATT, H. H. AND T. B. BOJARSKI. The Effects of Thymidine Administration on Thymidylate Kinase Activity and on DNA Synthesis in Mammalian Tissues 367
PITOT, H. C. AND Y. S. CHO. Studies on the Mechanism of Enzyme Induction' in Rat Liver 371
BAKEMEIER, R. A Possible Cellular Explanation of the Multiplicity of Steroid Reductases 379
GENERAL CONCLUSIONS
MONOD, J. AND JACOB, F. Teleonomic Mechanism in Cellular Metabolism, Growth, and Differentiation 389
List of Previous Volumes vi
Photographs of Some Participants vii
List of Those Attending the Symposium ix
OPENING ADDRESS
DAVIS, B. D. The, Teleonomic Significance of Biosynthetic Control Mechanisms 1
THE ROLE OF DNA IN PROTEIN SYNTHESIS
YANOFSKY, C., D. R. HELINSKI, AND B. D. MALING. The Effects of Mutation on the Composition and Properties of the A Protein of Escherichia coli Tryptophan Synthetase 11
STREISINGER, G., F. MUKAI, W. J. DREYER, B. MILLER, AND S. HORIUCHI. Mutations Affecting the Lysozyme of Phage T4 25
SIGNER, E. R., A. TORRIANI, AND C. LEVINTHAL. Gene Expression in Intergeneric Merozygotes 31
SUEOKA, N. Compositional Correlation between Deoxyribonucleic Acid and Protein 35
THE CONTROL OF NUCLEIC ACID SYNTHESIS
MAALĂE, O. The Control of Normal DNA Replication in Bacteria 45
SCHAECHTER, M. Patterns of Cellular Control during Unbalanced Growth 53
NEIDHARDT, F. C., AND D. G. FRAENKEL. Metabolic Regulation of RNA Synthesis in' Bacteria 63
THE ROLE OF DNA IN RNA SYNTHESIS
SPIEGELMAN, S. The Relation of Informational RNA to DNA 75
HURWITZ, J., J. J. FURTH, M. ANDERS, P. J. ORTIZ, AND J. T. AUGUST. The Enzymatic Incorporation of Ribonucleotides into RNA and the Role of DNA 91
THE ROLE OF RNA IN PROTEIN SYNTHESIS
BRENNER, S. RNA, Ribosomes, and Protein Synthesis 101
GROS, F., W. GILBERT, H. H. HIATT, G. ATTARDI, P. F. SPAHR, AND J. D. WATSON. Molecular and Biological Characterization of Messenger RNA 111
NOVELLI, G. D., T. KAMEYAMA, AND J. M. EISENSTADT. The Nature of the System Catalyzing the Synthesis of Induced b-Galactosidase 133
NISMAN, B., R. COHEN, A. KAYSER, H. FUKUHARA, J. DEMAILLY, C. GENIN, AND D. GIRON. Specific Protein Synthesis in Subcellular Systems of Escherichia coli 145
HOAGLAND, M. Some Factors Influencing Protein Synthetic Activity in a Cell-Free Mammalian System 153
PLESNER, P. Changes in Ribosome Structure and Function during Synchronized Cell Division 159
REGULATION OF ENZYME SYNTHESIS
VOGEL, H. J. Aspects of Repression in the Regulation of Enzyme Synthesis: Pathway-wide Control and Enzyme-specific Response 163
GORINI, L., W. GUNDERSEN, AND M. BURGER. Genetics of Regulation of Enzyme Synthesis in the Arginine Biosynthetic Pathway of Escherichia coli 173
MAAS, W. K. Studies on Repression of Arginine Biosynthesis in Escherichia coli 183
JACOB, F. AND J. MONOD. On the Regulation of Gene Activity 193
BUTTIN, G. Some Aspects of Regulation in the Synthesis of the Enzymes Governing Galactose Metabolism 213
YARMOLINSKY, M. B., E. JORDAN, AND H. WIESMEYER. Regulatory Mechanisms in the Synthesis of Enzymes of Galactose Metabolism. I. Coordinate Repression and De-Repression of the "Galactose Sequence." 217
KALCKAR, H. AND T. A. SUNDARARAJAN. Regulatory Mechanisms in the Synthesis of Enzymes of Galactose Metabolism. II. Genetic Defects in Galactokinase Activity and Their Relations to its Functions 227
HOROWITZ, N. H., M. FLING, H. MACLEOD, AND Y. WATANABE. Structural and Regulative Genes Controlling Tyrosinase Synthesis in Neurospora 233
NOVICK, A. AND a'. HORIUCHI. Hyper-Production of b-Galactosidase by Escherichia coli Bacteria 239 HORIUCHI, T. AND A. NOVICK. A Thermolabile Repression System 247
MAGASANIK, B. Catabolite Repression 249
KORNBERG, H. L. Selective Utilization of Metabolic Routes by Escherichia coli 257
ENGLESBERG, E., J. A. WATSON, AND P. A. HOFFEE. The Glucose Effect and the Relationship between Glucose Permease, Acid Phosphatase, and Glucose Resistance 261
CONTROL OF ENZYME ACTIVITY: COMPETITION BETWEEN ENZYMES
HOLZER, H. Regulation of Carbohydrate Metabolism by Enzyme Competition 277
CHANCE, B. Control Characteristics of Enzyme Systems 289
CONTROL OF ENZYME ACTIVITY: FEEDBACK CONTROL
UMBARGER, H. E. Feedback Control by Endproduct Inhibition 301
CHANGEUX, J. The Feedback Control Mechanism of Biosynthetic L-Threonine Deaminase by L-Isoleucine 313
STADTMAN, E. R., G. N. COHEN, G. LE BRAS, AND H. DE ROBICHON-SZULMAJSTER. Selective Feedback Inhibition and Repression of Two Aspartokinases in the Metabolism of Escherichia coli 319
MOYED, H. S. Interference with Feedback Control of Enzyme Activity 323
CONTROL OF ENZYME FORMATION AND ACTIVITY IN ANIMAL SYSTEMS
TOMKINS, G. M. AND K. L. YIELDING. Regulation of the Enzymic Activity of Glutamic Dehydrogenase Mediated by Changes in its Structure 331
MARKS, P. A. Glucose-6P Dehydrogenase Stability, Activation, and Inactivation 343
RALL, T. W. AND E. W. SUTHERLAND. The Regulatory Role of Adenosine-3', 5'-phosphate 347
POTTER, V. R. AND T. ONO. Enzyme Patterns in Rat Liver and Morris Hepatoma 5123 During Metabolic Transitions 355
SCHIMKE, R. T. Studies on Adaptation of Urea Cycle Enzymes in the Rat 363
HIATT, H. H. AND T. B. BOJARSKI. The Effects of Thymidine Administration on Thymidylate Kinase Activity and on DNA Synthesis in Mammalian Tissues 367
PITOT, H. C. AND Y. S. CHO. Studies on the Mechanism of Enzyme Induction' in Rat Liver 371
BAKEMEIER, R. A Possible Cellular Explanation of the Multiplicity of Steroid Reductases 379
GENERAL CONCLUSIONS
MONOD, J. AND JACOB, F. Teleonomic Mechanism in Cellular Metabolism, Growth, and Differentiation 389
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