Program
Organizers: James Darnell, Adrian Krainer, and Mila Pollock
- Mila Pollock
- Welcome
- James D. Watson
- Introduction: From the Volkin-Astrachan Experiment to the 1960 Discovery of mRNA at Harvard
Session 1: Bacterial mRNA, The Idea and Regulation
Chair: Tom Maniatis, Columbia University Medical Center, New York, NY
Keynote: Sydney Brenner Messenger RNA, The Idea and the Experiment (1960)
- Arthur Pardee
- RNA in the 1950s
- Matthew Meselson
- François, Sydney, and “X”
- Walter Gilbert
- Bacterial mRNA
- Robert Schleif
- What ARA C Taught Us
- Richard Burgess
- Prokaryotic RNA Polymerase
Session 2: The Successful Hunt for Eukaryotic mRNA and End Decorations
Chair: James Darnell, The Rockefeller University, New York, NY
- Jonathan Warner
- Polyribosomes: the Source for mRNA
- George Brawerman
- PolyA on Polyribosomal RNA
- Bernard Moss
- m7GpppNmp Caps on Viral and Cellular mRNA
Session 3: Origin of mRNA, Adenovirus to the Rescue
Chair: Joan Steitz, Yale University/HHMI, New Haven, CT
- James Darnell
- Primary Transcripts as Obligatory mRNA Precursors
- Richard Roberts
- Same 5' Undecanucleotide on All Late mRNAs: Implications
- Louise Chow
- EM Solves the Problem
- Arnold Berk
- Discovery of Splicing through Analysis of Adenovirus RNA
Session 4: Enzymes and Eukaryotic mRNA
Chair: Nahum Sonenberg, McGill University, Montreal, Quebec
- Robert Roeder
- Eukaryotic RNA Pol II and Biochemistry of Transcription
- Bernard Moss
- Capping Enzyme
- Stephen Buratowski
- Pol II and Coordination of Transcription and Processing
- James Manley
- 3'-end Cleavage, Polyadenylation, and Termination
Session 5: Mechanisms of Splicing
Chair: Richard Roberts, New England BioLabs, Ipswich, MA
- Joan Steitz
- Are snRNPs Involved in Splicing?
- Tom Maniatis
- Human β-globin, Fly Sex, and Pre-mRNA Splicing Machanisms
- Adrian Krainer
- Splicing Mutations, Disease, and Therapy
- Melissa Moore
- The Spliceosome: Dynamics and Disorder Defined
- Michel Morange
- mRNA: At the Crossroads Between Different Research Traditions
Session 6: Nascent RNA: Associated Proteins and Early Events
Chair: Robert Roeder, The Rockefeller University, New York, NY
- Georgii Georgiev
- Nuclear RNA and hnRNP Particles (Talk presented by Grigori Enikolopov, CSHL)
- Gideon Dreyfuss
- hnRNP Proteins
- Michael Rosbash
- Splicing on Nascent Transcripts in Yeast
- Douglas Black
- Events on Chromatin During Transcription
Session 7: Transport, Turnover, and Translation of Eukaryotic mRNA
Chair: Walter Gilbert, Harvard University, Cambridge, MA
- Nahum Sonenberg
- The Cap function in Translation: Mechanism and Control
- Robert Singer
- Spatial Regulation of mRNA Translation
- Juan Pablo Couso
- Small Open Reading Frames
- David Tollervey
- The Exosome
- Lynne Maquat
- Nonsense-mediated mRNA Decay
