HIV/AIDS Research:

Its History and Future

Genentech Center for the History of Molecular Biology and Biotechnology
at Cold Spring Harbor Laboratory Archives

Meeting: 13–16 October 2016

Organizers: Robert C. Gallo, John M. Coffin, Mila Pollock & Bruce D. Walker

Program

Organizers: Robert C. Gallo, John M. Coffin, Mila Pollock & Bruce D. Walker

Session 1: The Story of Animal Retroviruses

Co-chair: Julie Overbaugh     Fred Hutchinson Cancer Research Center
Co-chair: Steve Goff     HHMI Investigator, Columbia University
James D. Watson
Welcome
Mila Pollock
Introduction
Robert Gallo
Introduction
Robin Weiss
Retrovirus History, Early Searches for Human Retroviruses
John Coffin
Origin of Molecular Retrovirolory
Harold Varmus
Animal Retroviruses & Cancer Research
Myron Essex
From Feline Leukemia Virus to AIDS in Africa

Session 2: The Pandemic Begins: Early Discoveries

Co-chair: Michael Gottlieb     UCLA Medical Center
Co-chair: Bruce Walker     Ragon Institute of MGH, MIT and Harvard
Paul Volberding
The First Patients
James Curran
Deciphering the Epidemiology of AIDS
Mark Harrington
The Importance of Activism to the US Response
Robert Gallo
Discoveries of Human Retrovirus their Linkage to
Disease as Causative Agents & Preparation for the Future
Françoise Barré-Sinoussi
Discovery of HIV
Anthony Fauci
35 Years of HIV/AIDS: Science and Policy

Session 3: Antiretroviral Therapy

Co-chair: Sandra Lehrman     Merck Research Labs
Co-chair: John Mellors     University of Pittsburgh
Marty St. Clair
Discovery of AZT as the First Anti-HIV Drug
Samuel Broder
The First Clinical Trials of Antiretroviral Drugs
Douglas Richman
Antiviral Drug Resistance and Combination ART
Raymond Schinazi
Discovery and Development of Novel NRTIs
Daria Hazuda
Discovery and development of Integrase Inhibitors
John Martin
Making it Simpler: A Single Pill to Treat HIV

Session 4: Human & Primate Retroviruses, Origin of HIV

Co-chair: Jeffrey Lifson     National Cancer Institute
Co-chair: Ruth Ruprecht     Texas Biomedical Research Institute
Ronald Desrosiers
The Origin of SIVmac: Non-human Primate Models for HIV
Martine Peeters
On the Road to HIV: Primate Lentiviruses
Beatrice Hahn
Apes to Humans: The Origin of HIV
Michael Worobey
Spread of HIV in the New World

Session 5: The Extraordinary Virus: Molecular Biology

Co-chair: Paul Bieniasz     HHMI Investigator, The Rockefeller University
Co-chair: Anna Marie Skalka     Fox Chase Cancer Center, Temple Health
Flossie Wong-Staal
Discovery of Human Retroviral Transactivators
Joseph Sodroski
Primate Host-Specific Selection of Immunodeficiency Virus Gag and Env Proteins
Michael Malim
Discovery of APOBEC Restriction
Edward Berger
Discovery of HIV Co-receptors
Andrew Rice
Mechanism of Tat Transactivation
Michel Emerman
Host-virus Co-evolution

Session 6: Immunology and Prevention

Co-chair: Harriet Robinson     GeoVax Incorporated
Co-chair: Dan Barouch     BIDMC/Ragon Institute of MGH, MIT and Harvard
Sharon Hillier
Development and Application of Pre-exposure Prophylaxis
Dennis Burton
How Does HIV Evade the Antibody Response?
Bruce Walker
Role of T Cells in Controlling HIV Infection
Barton Haynes
Development of HIV Vaccine: Steps and Missteps
Emilio Emini
Issues in HIV Vaccine Development: Will the Future be any Easier than the Past?
Robert Redfield
The PEPFAR Program to Treat HIV in Africa
Salim Abdool-Karim
Stopping the Spread of HIV in Developing Countries

Panel: Prospects for an HIV Vaccine

Prospects for an HIV Vaccine
Glenda Gray
Moderator: Panel Discussion
Genoveffa Franchini
Panel Discussion
Susan Zolla-Pazner
Panel Discussion
Lawrence Corey
Panel Discussion
Dan Barouch
Panel Discussion

Session 7: Pathogenesis and Prospects

Co-chair: Alan Perelson     Los Alamos National Laboratory, Santa Fe Institute
Co-chair: Ashley Haase     University of Minnesota
John Mellors
MACS and Beyond: Epidemiology, Viremia and Pathogenesis
David Ho
Understanding of HIV Infection through Dynamics
George Shaw
Transmitted/Founder HIV Genomes: What They Teach Us
Robert Siliciano
The Challenge of the HIV Reservoir
Sharon Lewin
Research to a Cure: A Possible Goal?
David Baltimore
Bringing it to an End (and where are we going?)

Session 8: Public Event / Panel

Co-chair: Andres Vahlne     Karolinska Institute, Sweden
Co-chair: Warner Greene     Gladstone Institute of Virology & Immunology/USCF
Jon Cohen
Responding to AIDS - A Journalist's View
Staffan Hildebrand
Face of AIDS Project
Victoria Harden
The Future of the History of AIDS

Wrap Up: What Have We Learned?

Organizer Wrap Up Panel
Robert Gallo
Organizer Wrap Up Panel
John Coffin
Organizer Wrap Up Panel
Mila Pollock
Organizer Wrap Up Panel
Bruce Walker
Organizer Wrap Up Panel