Center for Humanities History of Science Meetings

Program

Organizers: David Botstein, Rochelle Esposito, Gerald Fink, & Mila Pollock

Ludmila Pollock
Welcome and Introduction

Session 1: Early Influential Yeast Centers

Chair: Gerald Fink
Whitehead Institute for Biomedical Research
Bernard Dujon
Non-selective dynamics of the two yeast genomes
R.E. Esposito
The legacy of the Seattle Yeast Group
Morten C. Kielland-Brandt
Yeast origins in Copenhagen and some of their continuations
Giora Simchen
Enhanced mutagenicity in meiosis - Timing and associated recombination
Gerald Fink
Yeast BC and AC

Session 2: Mitosis, meoisis and growth controls

Chair: John Pringle
Stanford University of School of Medicine
Frederick Cross
What's true of budding yeast and fission yeast is true of ...
Kerry Bloom
Biophysics of the yeast centromere
Douglas Koshland
Higher order chromosome structure in yeast, another yeast oxymoron
Virginia Zakian
Telomere biology - Contributions from S. cerevisiae
R.E. Esposito
Understanding Meiosis
Tim Stearns
A Hartwellian approach to understanding the mammalian cell cycle
Trisha Davis
Building a kinetochore from chromosome to microtubule
Kim Nasmyth
Cohesion establishment, a case of belt and braces - Identification of a pathway that converts cohesion assoicated with unreplicated DNA into structures that hold together replicated sisters and a second one that likely involves de novo loading
Douglas Bishop
RecA family strand exchange proteins in budding yeast

Session 3: RNA Synthesis, processing, translation and regulation

Chair: Christine Guthrie
University of California, San Francisco
Anita Hopper
Forty-two years fascination with yeast tRNA biology
Alan Hinnebusch
The key role of yeast genetics in deciphering the eukaryotic mechanism of initiation codon selection and translational control by upstream open-reading-frames
Sujsan Liebman
Yeast from basic genetics to human protein misfolding disease
Reed Wickner
Antiprion and antiviral systems in S. cerevisiae
David Garfinkel
The yeast retrotransposon Ty1 - A personal journey of discovery

Session 5: Gene expression and silencing

Co-chair: Mark Johnston
University of Colorado
Co-chair: Michael Grunstein
University of California
Michael Grunstein
Histones and histone modifications regulate transcription
Fred Winston
Genetic analysis of factors that control transcription, chromatin structure, and genome stability
Alexander Johnson
How transcript circuits evolve and produce biological novelty
Kevin Struhl
Transcriptional regulation in yeast from near ground-zero to now
Danesh Moazed
Conserved features of yeast heterochromatin
Hiten Madhani
Evolutionary persistence of DNA methylation for millions of years after ancient loss of a de novo methyltransferase

Session 6: Protein Transport, Autophagy, Degradation and Signaling

Co-chair: Nava Segev
University of Illinois at Chicago
Co-chair: Jeremy Thorner
University of California, Berkeley
Nava Segev
Ypt/Rab GTPases in intersections of cellular trafficking and autophagy pathways
Randy Schekman
Genetic and biochemical dissection of the yeast secretory pathway
Scott Emr
Genetics of membrane traffic - ESCRTing proteins into the lysosome
David Drubin
The actin cytoskeleton's role in endocytic membrane trafficking
Susan Ferro-Novick
A COPII subunit acts with an autophagy receptor to target endoplasmic reticulum for degradation
Michael Hall
Evolution of the TOR field
Angelika Amon
Intracellular signal integration and transmission
Judith Frydman
Maintaining proteostasis - Yeast lessons on the pathways and principles of protein quality control
Mark Hochstrasser
Insights into the ubiquitin-proteasome system from yeast studies

Session 7: Mitochondria, metabolism and aging

Chair: Thomas Fox
Cornell University
Benjamin Tu
Unexpected regulators of signaling and metabolism revealed by yeast
Daniel Gottschling
Developing a comprehensive understanding of genetic and environmental contributions to cellular aging

Panel Discussion: Medical and Industrial Uses of Yeast

Co-chair: Gerald Fink
Whitehead Institute / MIT
Co-chair: Bruce Stillman
Cold Spring Harbor Laboratory
Kirsten Benjamin
Panel Discussion
Sue Klapholz
Panel Discussion
Richard Kolodner
Panel Discussion
Michael Snyder
Panel Discussion
Patrick Westfall
Panel Discussion

Session 8: DNA replication, recombination and Repair

Co-chair: Judith Campbell
California Institute of Technology
Co-chair: Thomas Petes
Duke University
Bonita Brewer
My 40-year obsession with yeast rDNS
James Broach
Nutritional control of growth and development in yeast
Bik Tye
Eukaryotic DNA replication - From genetics to atomic models
Bruce Stillman
Co-evolution of DNA replication origin specification and gene silencing
Thomas Petes
Genetic instability resulting from defective DNA replication
James Haber
Repairing broken chromosomes
Rodney Rothstein
Origins of W303, DSB repair, gene diruption and more ...
Nancy Kleckner
Seeing yeast chromosomes to elucidate meiosis
Scott Keeney
Breaking DNA during meiosis
Stephen Elledge
The DNA damage response - Self-awareness for DNA

Session 9: Genomics and evolution

Chair: Ronald Davis
Stanford University
Chair: Edward Louis
University of Leicester
Maynard Olson
Origins and future of yeast genomics
Kenneth Wolfe
The origin of HO endonuclease and its role in whole genome duplication
Charles Boone
Global genetic networks, cellular function, and the genotype-to-phenotype relationship
Philip Hieter
Yeast genetics and human disease - Setting a trap for cancer cells
Brenda Andrews
From phenotypes to pathways: global analysis of cellular networks using systematic yeast genetics and single cell image analysis
Edward Marcotte
Bloody yeast! From humanized yeast to vascular disrupting agents
Maitreya Dunham
Teaching yeast and teaching with yeast
Edward Louis
The ends of chromosomes are also beginnings
Bruce Stillman
Closing Remarks