Fifty Years of REVERSE TRANSCRIPTASE
Program
Organizers: John Coffin, Steve Goff, Anna-Maria Skalka, Steve Hughs, & Hung Fan
Session 1: The Discovery of Reverse Transcriptase
- Harold Varmus
- How reverse transcriptase facilitated the study of retroviruses by synthesizing probes that revealed unexpected features of their replication cycle and the origins of their oncogenes
- Sarah Temin
- Recollections of Howard Temin
- Peter K. Vogt
- The long dawn of RT
- John M. Coffin
- Howard Temin and the discovery of reverse transcriptase
- David Baltimore
- CSH and reverse transcriptase (the power of biochemistry)
Session 2: Mechanisms of Reverse Transcription, Other Viruses
- Chair: Alice Telesnitsky
- University of Michigan, Ann Arbor
- Chair: John Taylor
- Fox Chase Cancer Center, Philadelphia, Pennsylvania
- Stephen P. Goff
- How reverse transcriptase makes proviral DNA—Or, things you can learn with the right enzyme assay
- Eddy Arnold
- Diverse structures of HIV reverse transcriptase have led to many insights and life-saving drugs
- Karin Moelling
- RNase H—After half a century
- William S. Mason
- Hepatitis B viruses and reverse transcription — An historical perspective
- Maxine L. Linial
- Foamy virus Pol—An unusual enzyme encoded by an unusual retrovirus
- Thomas Hohn
- Replication of cauliflower mosaic virus
Session 3: Rt as Tool and Target
- Chair: Stephen P. Goff
- Columbia University Irving Medical Center, New York, New York
- Chair: Alan Rein
- National Cancer Institute, Frederick, Maryland
- Tom Maniatis
- Cloning and characterization of nearly full-length double stranded β-globin cDNA
- Jeffrey D. Lifson
- RT carries the (viral) load
- Hiroaki Mitsuya
- Discovery of reverse transcriptase inhibitors for treating HIV-1/AIDS
- Stefan G. Sarafianos
- Biochemical and structural studies to elucidate inhibition mechanisms of HIV Reverse transcriptase
- Douglas Richman
- Reverse transcriptase resistance as the rationale for combination antiretroviral therapy (ART)
- Stephen H. Hughes
- Mechanisms of resistance to inhibitors of HIV-1 reverse transcriptase
This Week in Virology (TWIV):
- David Baltimore
- Panel Discussion
- John M. Coffin
- Panel Discussion
- Harold Varmus
- Panel Discussion
Session 4: Rt and Evolution: Other Retroelements and Normal Roles
- Chair: Jeremy Luban
- University of Massachusetts Medical School, Worcester
- Chair: Henry Levin
- NICHD, National Institutes of Health, Bethesda, Maryland
- Jef D. Boeke
- 40 years of retrotransposon reverse transcriptases
- Anna Marie Skalka
- Unexpected Inheritance—Non-retroviral endogenous viral elements
- John V. Moran
- The impact of LINE-1 reverse transcriptase activity on the human genome
- Irina R. Arkhipova
- The amazing diversity of reverse transcriptases
- Kathleen Collins
- Telomerase activity, biogenesis, and regulation—Coordination, co-folding, and co-evolution of telomerase reverse transcriptase, telomerase RNA, and telomerase holoenzyme proteins
- Alan M. Lambowitz
- Structure, function, evolution, and applications of group II intronencoded non-LTR-retroelement reverse transcriptases
- Jeffery F. Miller
- Accelerated protein evolution by diversity-generating retroelements
Session 5: Rt, Retroviruses, and Disease
- Chair: Hung Fan
- University of California, Irvine
- Chair: Karen Beemon
- Johns Hopkins University, Baltimore, Maryland
- J. Michael Bishop
- How a chicken virus opened the black box of cancer
- Robert A. Weinberg
- The discoveries of cellular oncogenes
- Benjamin G. Neel
- From Myc to SHP2
- Jaquelin Dudley
- Mouse mammary tumor virus—A model system for molecular biology, cancer, and immunity
- Robert C. Gallo
- Reverse transcriptase and the discoveries of human retroviruses
- Ronald Desrosiers
- Contributions of SIV to our Knowledge Base for HIV/AIDS
- John M. Sedivy
- Retrotransposon derepression in cellular senescence and aging
Session 6: Rt and Evolution: Endogenous Retroviruses I
- Chair: Jaquelin Dudley
- University of Texas at Austin
- Chair: John M. Coffin
- Tufts University, Boston, Massachusetts
- Robin A. Weiss
- Discovery of endogenous retroviruses
- Christine A. Kozak
- The evolution of endogenous retroviruses
- Alex Greenwood
- Koala retrovirus—An unlikely host provides a model for how retroviruses colonize vertebrate genomes in real-time
- Malcolm Martin
- Discovery of human endogenous retroviruses
Session 7: Rt and Evolution: Endogenous Retroviruses Ii
- Chair: Jaquelin Dudley
- University of Texas at Austin
- Chair: John M. Coffin
- Tufts University, Boston, Massachusetts
- Jonathan Stoye
- Endogenous retroviruses as restriction factors—Fv1 and others of a similar ilk
- Welkin E. Johnson
- Reverse transcriptase and the origins of viral species
- Thierry Heidmann
- Retroelements and endogenous retroviruses—Mobilisation and control of coding and non-coding elements, processed pseudogene formation and generation of new physiological functions with the captured retroviral envelopes «syncytins»
- John M. Coffin
- Concluding Remarks