2012.07 Newsletter

Library Newsletter/Special Edition, July 2012

Current Library & Archives Exhibitions

Plant Molecular Genetics at Cold Spring Harbor 1892-2012

The exhibition, “Plant Molecular Genetics at Cold Spring Harbor 1892-2012: Planting the Seeds of Knowledge in Education, Research and Discovery“, on view at Blackford details the history of plant biology at Cold Spring Harbor from the late 1800s through the present day. Plant genetics originated in CSHL with the inception in 1892 of a botany course of the Brooklyn Institute of Arts and Sciences Biological Laboratory. Shortly thereafter, the early scientific breakthroughs of C.I.W. Station for Experimental Evolution scientists such as George Shully, (hybridization of corn), brought plant science into real world applications.

C.I.W. Department of Genetics Scientist Barbara McClintock received the Nobel Prize in Physiology or Medicine in 1983 for her earlier discovery of “jumping genes”. The work currently being done by current CSHL plant geneticists builds upon McClintock’s research in the 1940s and 1950s.

In the 1980s, the laboratory acquired the Uplands Farm where the staff raises maize, tomato and Arabidopsis plants for study. In 1981, Delbrück-Page Laboratories were built as a home for the plant genetics program at CSHL.

Plant geneticists, including David Jackson, Rob Martienssen, Marja Timmermans, Zachary Lippman and Doreen Ware, work on the cutting edge of plant genetics, through its involvement in plant genome sequencing, the iPlant consortium and the Long Island Biofuels Alliance. This exhibit is on view until September 2012

Get to know Alfred D. Hershey

Alfred Hearshey

Get to know Alfred D. Hershey, in the two new exhibitions about his life and science currently on view in the lobby of the new Hershey Building. Presented by the CSHL Library & Archives, the exhibition, Alfred Day Hershey, Nobel Prize Winner, 1908-1997, consists of two parts: his personal life and scientific career. Hershey’s personal life is illuminated through correspondence and photos (drawn from the CSHL Alfred Hershey Collection) of his family and close friends, and information about his many hobbies. Included are letters between Hershey and his wife, Jill Davidson, whom he met while visiting CSHL in 1945. The exhibition is also a celebration of Hershey’s scientific career featuring documents pertaining to his research on bacteriophage for which he shared the Nobel Prize in 1969 with Max Delbrück and Salvador Luria. Other documents and correspondence are included, as well.

A photographic history of the Hershey Building, 1906-2012, is also on display in the Hershey Building. The exhibit traces the transformation of the building from its earliest days as a greenhouse for plant geneticists, through its renovation as a research laboratory in the late 1970s, to its current rebuilding as a teaching laboratory for course attendees.

The Double Helix Opening

The Double Helix Book Cover

The Opening of an exhibition about the writing of The Double Helix was held in the CSHL Library on Wednesday, June 27th. The book, written by James D. Watson and published in 1968, was recently chosen by the Library of Congress as one of the Books That Shaped America, and is currently featured in an exhibition there.

The Double Helix is Dr. Watson’s first-hand account of the events leading up to the discovery of the structure of DNA. The personal account documents not just the science but also the personalities of the major players in the story of one of science’s most important discoveries.

Our exhibit will be displayed until August 31, 2012, in the Zinder Reading Room at the Library. The exhibit features original documents that trace the story of the publication of The Double Helix, from its rejection by the Harvard University Press to its placement on the New York Times Best Seller List. All materials in the exhibit are courtesy of the James D. Watson Collection at the CSHL Archives.

Therapeutic applications of quadruplex nucleic acids

Neidle, S. (2012). Therapeutic applications of quadruplex nucleic acids. Academic Press, CA.

The author provides information on the three-dimensional structure of quadruplex nucleic acids and their importance as therapeutic targets. Topics include the structure of human telomeric DNA quadruplexes, RNA quadruplexes, and design principles for quadruplex-binding small molecules. Google Book Preview. CSHL Catalog.

Cancer epigenetics: biomolecular therapeutics for human cancer

Giordano, A. Ed. (2011). Cancer epigenetics: biomolecular therapeutics for human cancer. John Wiley & Sons, NJ.

This title features contributions from various researchers in the development of new therapeutic approaches to cancer therapy. Topics include epigenetic modulation of the cell cycle, control in cellular senescence, mechanisms in cancer formation and progression, and epigenetic targets in cancer therapy. Google Books Preview. Check the Library Catalog for availability.

The origins of schizophrenia

Brown, A.S. Ed. (2012). The origins of schizophrenia. Columbia University Press, NY.

Various investigators provide their insights into the neurobiological nature of this psychotic illness. Topics include presumptive susceptibility genes, animal models of environmental factors and clinical research on the maternal aspects that impact the lifetime trajectory of this disease. Google Book PreviewCSHL Catalog.