at Cold Spring Harbor Laboratory

The Evolving Concept of Mitochondria:
From Symbiotic Origins to Therapeutic Opportunities

 October 18 - 21, 2018


Anu Suomalainen, University of Helsinki, Finland
John E. Walker
, MRC Mitochondrial Biology Unit, University of Cambridge, United Kingdom
Douglas C. Wallace, Children's Hospital of Philadelphia & University of Pennsylvania
Mila Pollock, Cold Spring Harbor Laboratory

Since it was first observed within cells at the end of the nineteenth century, our bacterial endosymbiont, the mitochondrion, has been interrogated from many perspectives.  Initially described as a cytoplasmic structure, then as the source of energy, later an organismal entity, and recently a component of many diseases, the multi-faceted mitochondrion has engendered fascination from a broad spectrum of physical, chemical, biological, and medical perspectives.  

What is this cell-within-a-cell? Where did it come from? What is its relevance to our health and well being? How will mitochondrial knowledge affect the future?  These are the questions we hope to discuss in this stimulating meeting of modern mitochondriacs who will discuss past, current state and future prospects through their important contributions to the field. 

The meeting on The Evolving Concept of Mitochondria: From Symbiotic Origins to Therapeutic Opportunities will begin at 7:00 PM on Thursday, October 18th and conclude Sunday, October 21st at 4:30 PM.

SciVal - Research Performance and Trends


The CSHL LIbrary and Archive is pleased to announce that SciVal, Elsevier's platform to visualize research performance, benchmark your science relative to peers, develop collaborative partnerships and analyze research trends, is now available.

For more information about SciVal please contact  the Library.

Please join us for our last seminar this month with Dr. Fatih Mercan, on Tuesday, February 13 at 10:30am, in the at the Library's Rare Book Room in the Carnegie Building.

Dr. Fatih Mercan is a patent agent at the life sciences group at Scully Scott Murphy & Presser P.C., in Garden City, NY. Dr. Mercan is also a first year J.D. student (part-time, evening division) at St. John's University School of Law. Dr. Mercan is registered to practice before the U.S. Patent & Trademark Office. Dr. Mercan's current practice includes preparation and prosecution of patent applications, as well as assisting with due diligence matters, patent landscape assessments, freedom to operate analysis, and patentability analysis.

Dr. Mercan has a scientific training in cell signaling and cancer. Before joining Scully, Scott, Murphy & Presser in 2015, Dr. Mercan was a postdoctoral fellow at Cold Spring Harbor Laboratory (Vakoc Lab, 2012-2015) performing research on the epigenetic pathways of Acute Myeloid Leukemia (AML) and AML drug target discovery. Dr. Mercan received his Ph.D. in Pharmacology from Yale University. His doctoral research focused on the regulatory role of the protein tyrosine phosphatase SHP-2 in nutrient sensitive mTOR pathway.

Brief description of my talk: Dr. Mercan will share his experiences about his transition from being a postdoc at CSHL to a career in Intellectual Property (IP) law.

A Short History of Quantitative Biology at Cold Spring Harbor Laboratory

Posted on March 2, 2015 by adamsiepel

In my spare time, I enjoy reading about the history of science, and since arriving at Cold Spring Harbor Laboratory last August, I have been particularly interested in the role of CSHL in the history of genetics and molecular biology. I have been especially struck by the large number of prominent quantitative biologists who have been affiliated with the Laboratory, in one way or another, and I thought it would be useful to draft a short history focused on quantitative biology at CSHL.

Read more

Perspectives on Science Careers3

The Perspectives on Science Careers seminar series returns for 2018.
Please join us for our first seminar which will feature David Kolosic, on Friday, February 9th at 3:00pm, in the Szybalski Room at the Library.
David will join us to discuss the path of his career which has lead him to his position as a Regulatory Information Specialist and Business Developer at ASPHALION, a pharmaceutical company based in Barcelona, Spain. Please find his bio below. Join us for a brief presentation by David and bring your questions for an extensive Q&A to follow. The seminar will be followed by tea/coffee and cookies in the library.

We hope to see you there!

Polona Safaric Tepes and the Library

Speaker Bio
David Kolosic is a Regulatory Information Specialist and Business Developer at ASPHALION for pharma companies in Barcelona, Spain. He bridging the gap between the company’s expertise and the challenges faced by the pharmaceutical industry in the area of eSubmissions. David holds a BSc in Pharmaceutical Studies and a MSc in Pharmaceutical Science and Management Studies from Kingston University London. His previous work experience includes being Quality Assurance Compliance professional in Krka, where he was responsible for monitoring, implementation and control of the implementation of international and national regulations, guidelines and recommendations in the area of quality assurance.

Double Helix Book

The Double Helix was published February 26, 1968. Half a century after the publication, Roger Highfield from the Science Museum, London looks at why this book is still relevant today. Read about it in the Science Museum blog.

The CSHL Library and Archives contains a large trove of original materials germane to the events described in The Double Helix, including items from the James D. Watson, Francis Crick, Sydney Brenner, and many other collections. Please visit our Digital Archives.

Dr. Eugene S. Flamm, Neurosurgeon and Rare Book Collector
Neurosurgery Before Neurosurgery: The Formative Years 1517-1867

Date:    Thursday, October 5, 2017, 4:30pm
Location:   Library, Szybalski Reading Room


Neurosurgery as a surgical discipline is often attributed to the early 20th Century. However, the transition to modern concepts of surgical intervention began in the 16th Century. This lecture will illustrate the early development of neuroanatomy and neurosurgery, with emphasis on a selection of illustrated material found in medical works published from the 16th through the 18th Centuries. The images include surgical portraits of patients, genre scenes of neurosurgeons at work, and anatomical dissections of the brain. During this time, the early signs of the modern concepts of surgical intervention were evident.

Eugene S. Flamm, MD, FAANS, FACS, FASA, is currently the Jeffrey P. Bergstein Professor of Neurosurgery and Chairman of the Department of Neurological Surgery at both the Albert Einstein College of Medicine and the University of Pennsylvania. After graduation from the University of Buffalo School of Medicine in 1962, Dr. Flamm became a respected expert on intracranial neurosurgery, specializing in aneurysms, brain tumors, and vascular malformations. His career has taken him from his training at Cornell-NY Hospital, NIH, NYU Medical Center and the University of Zurich to Professor and Chairman of Neurosurgery at both the University of Pennsylvania and the Albert Einstein College of Medicine. His love for books began at a very early age and eventually inspired him to study the Romantic poets while he was an undergraduate at Princeton. His rare book collections have focused on the history and anatomy of the brain and its surgery.

Forty Years of mRNA Splicing: From Discovery to Therapeutics

October 22 - 25, 2017


Mila Pollock, Cold Spring Harbor Laboratory
Phil Sharp, Massachusetts Institute of Technology
Joan Steitz, Yale University/HHMI

The meeting will be held in Grace Auditorium at Cold Spring Harbor commencing 1:45 pm on Sunday, October 22, and finish in the late afternoon on Tuesday, with departures the following morning, October 25, after breakfast.
Themes include:

    History and Overview
    Biology of Spliceosome
    Introns, Exons and Alternative splicing
    Spliceosome Complexes
    Diseases of mRNA splicing
    Therapeutic approaches to mRNA Splicing diseases

For these unique meetings, we invite speakers who made many of the seminal discoveries that began the field, as well as those who are working on the topic now.  We also invite historians of science who have examined the topic, setting it in its scientific and societal context.  Like the previous meetings in the series, this meeting will provide an excellent opportunity to look in-depth at a topic and share the stories that are often missing from academic accounts.

We anticipate the meeting will interest a broad range of individuals, including scientists, clinicians, historians, activists, and science journalists.

For more information and registration:

International Catalog of the History of the HGP

The Human Genome Project (HGP) was a 13-year initiative to sequence the billions of individual bases of human DNA. Despite the landmark nature of the project, there was never any effort to preserve, collect or organize the documentary record of scientists’ work in six countries: this historical documentation lay scattered in archives and other collections in the United States, United Kingdom, France, Germany, Japan, and China.

In 2009, Cold Spring Harbor Laboratory began working with The Wellcome Trust to change this. The International Catalog of the History of the Human Genome Project seeks to fill a large gap for historians and other scholars researching the HGP. The project will create a catalog of the original materials that came out of sequencing the human genome: correspondence, lab notes, photographs, papers, grant applications, oral history interviews, and other files.

For the first time, all the relevant materials documenting the history of the HGP will be identified, organized, and catalogued for the public. The website for the International Catalog of the History of the Human Genome Project is available at

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Congrats to the team at Base Pairs Podcast for their Platinum Award! This is a well deserved award.
RT @BookChat_: Who said librarians don't have a sense of humor?