at Cold Spring Harbor Laboratory

Dr. Eugene S. Flamm, Neurosurgeon and Rare Book Collector
Neurosurgery Before Neurosurgery: The Formative Years 1517-1867

Date:    Thursday, October 5, 2017, 4:30pm
Location:   Library, Szybalski Reading Room


Neurosurgery as a surgical discipline is often attributed to the early 20th Century. However, the transition to modern concepts of surgical intervention began in the 16th Century. This lecture will illustrate the early development of neuroanatomy and neurosurgery, with emphasis on a selection of illustrated material found in medical works published from the 16th through the 18th Centuries. The images include surgical portraits of patients, genre scenes of neurosurgeons at work, and anatomical dissections of the brain. During this time, the early signs of the modern concepts of surgical intervention were evident.

Eugene S. Flamm, MD, FAANS, FACS, FASA, is currently the Jeffrey P. Bergstein Professor of Neurosurgery and Chairman of the Department of Neurological Surgery at both the Albert Einstein College of Medicine and the University of Pennsylvania. After graduation from the University of Buffalo School of Medicine in 1962, Dr. Flamm became a respected expert on intracranial neurosurgery, specializing in aneurysms, brain tumors, and vascular malformations. His career has taken him from his training at Cornell-NY Hospital, NIH, NYU Medical Center and the University of Zurich to Professor and Chairman of Neurosurgery at both the University of Pennsylvania and the Albert Einstein College of Medicine. His love for books began at a very early age and eventually inspired him to study the Romantic poets while he was an undergraduate at Princeton. His rare book collections have focused on the history and anatomy of the brain and its surgery.

Forty Years of mRNA Splicing: From Discovery to Therapeutics

October 22 - 25, 2017


Mila Pollock, Cold Spring Harbor Laboratory
Phil Sharp, Massachusetts Institute of Technology
Joan Steitz, Yale University/HHMI

The meeting will be held in Grace Auditorium at Cold Spring Harbor commencing 1:45 pm on Sunday, October 22, and finish in the late afternoon on Tuesday, with departures the following morning, October 25, after breakfast.
Themes include:

    History and Overview
    Biology of Spliceosome
    Introns, Exons and Alternative splicing
    Spliceosome Complexes
    Diseases of mRNA splicing
    Therapeutic approaches to mRNA Splicing diseases

For these unique meetings, we invite speakers who made many of the seminal discoveries that began the field, as well as those who are working on the topic now.  We also invite historians of science who have examined the topic, setting it in its scientific and societal context.  Like the previous meetings in the series, this meeting will provide an excellent opportunity to look in-depth at a topic and share the stories that are often missing from academic accounts.

We anticipate the meeting will interest a broad range of individuals, including scientists, clinicians, historians, activists, and science journalists.

For more information and registration:

International Catalog of the History of the HGP

The Human Genome Project (HGP) was a 13-year initiative to sequence the billions of individual bases of human DNA. Despite the landmark nature of the project, there was never any effort to preserve, collect or organize the documentary record of scientists’ work in six countries: this historical documentation lay scattered in archives and other collections in the United States, United Kingdom, France, Germany, Japan, and China.

In 2009, Cold Spring Harbor Laboratory began working with The Wellcome Trust to change this. The International Catalog of the History of the Human Genome Project seeks to fill a large gap for historians and other scholars researching the HGP. The project will create a catalog of the original materials that came out of sequencing the human genome: correspondence, lab notes, photographs, papers, grant applications, oral history interviews, and other files.

For the first time, all the relevant materials documenting the history of the HGP will be identified, organized, and catalogued for the public. The website for the International Catalog of the History of the Human Genome Project is available at

Sydney Brenner Research Scholarship & Travel Grant

Perspectives on Science Careers3

The Perspectives on Science Careers seminar, June 22th 2017

The Perspectives on Science Careers seminar series for June, hosted by the PDLC and the Library and Archives, will feature Dr. Lydia Villa-Komaroff, who will give a lecture about the importance of increasing diversity in STEM and how we can address these issues on our campus. She was the third Mexican-American woman in the USA to receive a PhD in the sciences and is a co-founding member of The Society for the Advancement of Chicanos/Hispanics and Native Americans in Science (SACNAS).

Please join us for a brief presentation by Dr Villa-Komaroff and bring your questions for an extensive Q&A to follow. The Q&A will be followed by tea/coffee networking session in the Library.

We hope to see you there!

 When:            Thursday, June 22, 2017

 Time:             3:00 pm – 4:00 pm

 Where:           Szybalski Reading Room, CSHL Library       

 Speaker:       Dr. Lydia Villa-Komaroff 

Speaker Bio
Lydia Villa-Komaroff is a molecular/cell biologist who's had a long and storied career in both academia and industry as a laboratory scientist, administrator, business executive, and advocate. She currently serves on the Board of Cytonome/ST LLC, which develops purpose-built cell sorters, after serving as its CEO for four years. She’s also on the Board of Directors for ATCC, the biological standards and reagents organization. She’s held faculty positions at the University of Massachusetts Medical Center and Harvard Medical School, and was Vice-President for Research at Northwestern University as well as Vice-President for Research and Chief Operating Officer of the Whitehead Institute.
Among her many awards and accolades, she is a fellow of AAAS and AWiS (Association for Women in Science), was a founding member of SACNAS (1973, Society for Advancement of Chicanos/Hispanics & Native Americans in Science), has received a Lifetime Achievement Award by Hispanic Business Media (2008), has received the MIT Morison Prize in Science Technology & Society (2016), and was an honorary co-chair of the Washington D.C. March for Science (2017).

During her career as a bench scientist, Dr. Villa-Komaroff used recombinant DNA as a tool to address a number of fundamental questions in biology. In 1975, she received a Ph.D. in cell biology from MIT under the mentorship of David Baltimore and Harvey Lodish. She then moved onto a postdoc at Harvard, initially in the laboratory of Fotis Kafatos. When Cambridge banned recombinant DNA experiments in 1976, she moved to CSHL for a year to continue her research as a visiting scientist in Tom Maniatis's laboratory. After the ban was lifted, she returned to Harvard as a postdoctoral fellow in Wally Gilbert's lab and soon after, published the landmark manuscript showing that bacteria could be induced to make proinsulin. This was the first time a mammalian hormone had been synthesized by bacteria, a discovery that essentially solved the problem of insulin mass-production for diabetics. Additional contributions from her research career include studies of insulin-like growth factors in developing tissues, the role of proinsulin c-peptide sequence in insulin secretion, the connection between sensory experience and gene expression during development of the visual cortex, and the first demonstration of amyloid toxicity in neural cells.


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Images from Recent Publications @ CSHL

  • Ballouz & Gillis Genome Med 2017

    Functional convergence trend calculation

  • Li et al eLife 2017

    Dynamic expression of lncRNA Ephemeron during exit from naïve pluripotency

  • Lu et al Nat Neurosci 2017

    Optogenetic activation of L2 ChCs in PL inhibits PL firing, including BLAPC firing, in freely behaving mice

  • Romero-Hernandez & Furukawa Mol Pharmacol 2017

    Ligands and domain organization of NMDA receptors

  • Wu & Tollkuhn Mol Pharmacol 2017

    Neonatal deletion of Esr1 in Vglut2+ and Vgat+ neurons

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